KEGG ORTHOLOGY: K26496

ORTHOLOGY: K26496

Entry

K26496                      KO

Symbol

RAB5IF

Name

GEL complex subunit OPTI

Disease

H02415

Craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K26496  RAB5IF; GEL complex subunit OPTI
Membrane trafficking [BR:ko04131]
Endosome - Lysosome transport
  Rab GTPases and associated proteins
   Rab associated proteins
    K26496  RAB5IF; GEL complex subunit OPTI
Endoplasmic reticulum (ER) - Golgi transport
  Others
   Multi-pass translocon (MPT) complex
    K26496  RAB5IF; GEL complex subunit OPTI

Genes

HSA:	55969(RAB5IF)

PTR:	735483(RAB5IF)

PPS:	103782653(RAB5IF)

GGO:	109023054(RAB5IF)

PON:	100432107(RAB5IF)

PPYG:

129021609(RAB5IF)

NLE:	100594854(RAB5IF)

HMH:	116460755(RAB5IF)

SSYN:

129474178(RAB5IF)

MCC:	709696(C10H20orf24)

MCF:	101926585(RAB5IF)

MTHB:

126964322

MNI:

105496299

CSAB:

103220951(C2H20orf24)

CATY:

105582347

PANU:

103875485(RAB5IF)

TGE:

112632819

MLEU:

105533814

RRO:	104680549(RAB5IF)

RBB:

108523052

TFN:	117068732(RAB5IF)

PTEH:

111548200(RAB5IF)

CANG:

105502529

CJC:	100408380(RAB5IF)

SBQ:

104649856

CIMI:

108292090

ANAN:

105708943 105719167(RAB5IF)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	67388(Rab5if)

MCAL:

110283693

MPAH:

110318241

RNO:	296315(Rab5if)

MCOC:

116091274(Rab5if)

ANU:	117704544(Rab5if)

ASYL:

127686160(Rab5if)

MUN:	110556945(Rab5if)

CGE:

100763162

MAUA:

101836760(Rab5if)

PROB:

127224768(Rab5if)

PLEU:

114681840(Rab5if)

MORG:

121460125

MFOT:

126506829

AAMP:

119814186

NGI:	103748512(CUNH20orf24)

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138816952(Rab5if)

PLOP:

125353447(Rab5if)

NCAR:

124976147

MMMA:

107138433(Rab5if)

ITI:	101965160(Rab5if)

OCU:

100342874

OPI:

101535698

OCZ:	121157363(RAB5IF)

TUP:

102484257

GVR:

103592489

CFA:	485858(RAB5IF)

CLUD:

112673895(RAB5IF)

VVP:	112928187(RAB5IF)

VLG:	121477911(RAB5IF)

NPO:	129494256(RAB5IF)

AML:

100466398

UMR:	103669905(RAB5IF)

UAH:	113258559(RAB5IF)

UAR:	123796952(RAB5IF)

ELK:

111141349

LLV:

125108509

MPUF:

106003404

MNP:	132021892(RAB5IF)

MLK:	131807734(RAB5IF)

NVS:

122916105

ORO:

101363273

EJU:

114220821

ZCA:	113937048(RAB5IF)

MLX:

118011445

NSU:

110579696

LWW:	102732102(RAB5IF)

FCA:	102899611(RAB5IF)

PYU:

121012243

PCOO:

112868822

PBG:

122496315

PVIV:

125161741(RAB5IF)

LRUF:

124503150

LGF:	123580262(RAB5IF)

AJU:

PTG:

PPAD:

PUC:

PLEZ:

122215591(RAB5IF)

HHV:

120228603

BTA:	512377(RAB5IF)

BOM:	102288093(RAB5IF)

BIU:

109567420

BBUB:

102393036(RAB5IF)

BBIS:

104980504 104996743

CHX:

102177994

OAS:	101121958(RAB5IF)

BTAX:

128058258(RAB5IF)

CSUM:

138091276(RAB5IF)

ODA:

120868650

CCAD:

122447928

MREE:

136159564(RAB5IF)

OVR:	110136390(RAB5IF)

MBEZ:

129563154(RAB5IF)

SSC:	100155351(C17H20orf24)

CFR:	102508542(RAB5IF)

CBAI:

105073507

CDK:

105084980

VPC:	102529645(RAB5IF)

BACU:

103013033

BMUS:

118880879

LVE:

103076322

OOR:	101271362(RAB5IF)

LALB:

132506500(RAB5IF)

GMF:	115839267(RAB5IF)

DDP:	132437577(RAB5IF)

DLE:

111184216

PCAD:

102984638(RAB5IF)

PSIU:

116739630

PPHC:

136134630(RAB5IF)

NASI:

112396243 112398606(RAB5IF)

ECB:	100147598(C22H20orf24)

EPZ:	103557628(RAB5IF)

EAI:	106835046(RAB5IF)

MYB:

102258234

MYD:

102751334

MMYO:

118662665(RAB5IF)

MLF:	102423983(CUNH20orf24)

MDT:	132239582(RAB5IF)

MYUM:

139013864(RAB5IF)

PKL:	118707703(RAB5IF)

EFUS:

103293322(RAB5IF)

MNA:

107542137

DRO:

112304058

SHON:

118985438(RAB5IF)

AJM:	119063170(RAB5IF)

PDIC:

114506313(RAB5IF)

PHAS:

123814768(RAB5IF)

MMF:

118618651

PPAM:

129070728(RAB5IF)

HAI:

109389609

RFQ:

117015726

PALE:

102887622(RAB5IF)

PGIG:

120603623

PVP:	105296472(CUNH20orf24)

RAY:

107512611

MJV:	108388032(RAB5IF)

TOD:	119233384(RAB5IF)

SARA:

101538544

SFUM:

130030255(RAB5IF)

SETR:

126017474(RAB5IF)

LAV:

100672907

TMU:

101345681

ETF:

101638219

MDO:	100028999(C1H20orf24)

GAS:

123237429

SHR:	100918163(RAB5IF)

AFZ:

127550378

PCW:	110216755(CUNH20orf24)

TVP:	118844053(RAB5IF)

PBRV:

138153507(RAB5IF)

MLAO:

141488515 141503207 141505817(RAB5IF)

OAA:	100077328(RAB5IF)

TACU:

119931630(RAB5IF)

GGA:	768550(C20H20ORF24)

PCOC:

116236862(RAB5IF)

MGP:	100541631(RAB5IF)

CJO:	107322804(RAB5IF)

TPAI:

128080913(RAB5IF)

LMUT:

125701354(RAB5IF)

NMEL:

110408207(C19H20orf24)

APLA:

101790861(RAB5IF)

ACYG:

106045399(RAB5IF)

CATA:

118248813(RAB5IF)

AFUL:

116495834(RAB5IF)

TGU:	100218493(RAB5IF)

LSR:	110473789(RAB5IF)

SCAN:

103823661(RAB5IF)

OTC:	121332613(RAB5IF)

PRUF:

121365909(RAB5IF)

ATRC:

139604298(RAB5IF)

GFR:

102045598

FAB:	101818333(C20H20orf24)

OMA:	130261411(RAB5IF)

PHI:

102114698

PMAJ:

107213092(RAB5IF)

CCAE:

111938348(C20H20orf24)

CCW:	104698026(RAB5IF)

CBRC:

103624258(CUNH20orf24)

ACOE:

138121030(RAB5IF)

ETL:	114059724(RAB5IF)

ZAB:	102069846(RAB5IF)

ZLE:	135456351(RAB5IF)

ACHL:

103802537

SVG:

106859196

MMEA:

130579693(RAB5IF)

HRT:	120760209(RAB5IF)

SATI:

136368672(RAB5IF)

CCIC:

134051241(RAB5IF)

FPG:

101915426

FCH:	102051124(RAB5IF)

CCRI:

104156992

NNT:

104401313

SHAB:

115615235(RAB5IF)

ACUN:

113490651(RAB5IF)

TALA:

104356759(RAB5IF)

ACHC:

115339697(RAB5IF)

HALD:

104321860

HLE:

104829962

AGEN:

126045319

HHAR:

128143692(RAB5IF)

GCL:

127023182

CSTI:

104552243

DPUB:

104302832

PPUS:

135188136(RAB5IF)

AVIT:

104269749

BRHI:

104497569

EGZ:	104125323(RAB5IF)

NNI:

PCRI:

PCAO:

PADL:

AFOR:

103902248(CUNH20orf24)

FGA:

104075417

CBOR:

142089581(RAB5IF)

GSTE:

104253055

CBOY:

140659511(RAB5IF)

MAME:

142416934(RAB5IF)

CLV:	102097054(CUNH20orf24)

CNIC:

135994801(RAB5IF)

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

104063244(RAB5IF)

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:	128916645(RAB5IF)

CRID:

134522462(RAB5IF)

LMIC:

141750287(RAB5IF)

AAM:

106499892

AROW:

112968477(RAB5IF)

NPD:	112945692(RAB5IF)

TGT:

104578087

DNE:	112983190(RAB5IF)

SCAM:

104146925

ASN:	102388264(RAB5IF)

AMJ:	102575382(CUNH20orf24)

CPOO:

109313253(CUNH20orf24)

GGN:	109294589(CUNH20orf24)

PSS:	102448417(RAB5IF)

CIZ:	142022277(RAB5IF)

CMY:	102943036(RAB5IF)

CCAY:

125622241(RAB5IF)

DCC:	119842286(RAB5IF)

CPIC:

101947217(RAB5IF)

TST:	117885859(RAB5IF)

CABI:

116818601(RAB5IF)

MRV:	120381253(RAB5IF)

ACS:	100565109(c4h20orf24)

ASAO:

132773229(RAB5IF)

PVT:	110083034(CUNH20orf24)

PBI:	103050137(RAB5IF)

PMUR:

107288382(RAB5IF)

CTIG:

120299177(RAB5IF)

TSR:

106538626

PGUT:

117663664(RAB5IF)

PCAE:

139314357(RAB5IF)

APRI:

131194506(RAB5IF)

PTEX:

113434440(RAB5IF)

NSS:	113421338(RAB5IF)

VKO:	123032004(RAB5IF)

PMUA:

114599522(RAB5IF)

PRAF:

128416342(RAB5IF)

ZVI:	118089227(RAB5IF)

HCG:	128322742(RAB5IF)

GJA:

107112271

STOW:

125433742(RAB5IF)

EMC:	129330555(RAB5IF)

XLA:	443778(rab5if.S) 446521(rab5if.L)

XTR:	549216(rab5if)

NPR:	108786802(CUNH20orf24)

RTEM:

120918702(RAB5IF)

ACAT:

141113323(RAB5IF) 141113373

BBUF:

121004618(RAB5IF)

BGAR:

122942296(RAB5IF)

DTC:	141059108(RAB5IF)

PWL:	138304077(RAB5IF)

MUO:	115476558(RAB5IF)

GSH:	117345889(RAB5IF)

DRE:	334006(rab5if)

SRX:	107713559 107747730

SANH:

107680731 107703615

SGH:	107557487 107562621

CCAR:

109066472 122134019(rab5if)

CAUA:

113040972 113068658

CGIB:

127944718 128011410

PTET:

122329271(rab5if)

LROH:

127154340(rab5if)

GRF:	141291396(rab5if)

OMC:	131532240(rab5if)

PPRM:

120491902(rab5if)

RKG:	130077766(rab5if)

MAMB:

125260258(rab5if)

CIDE:

127504900

CERY:

137009452(rab5if)

MASI:

127418957 127419807

TROS:

130545105(rab5if)

TDW:	130409784(rab5if)

MANU:

129430735(rab5if)

PDAB:

135772982(rab5if)

IPU:	108275801(rab5if)

IFU:	128619389(rab5if)

SMEO:

124399125(rab5if)

TFD:	113651789(rab5if)

TVC:	132862641(rab5if)

CGAR:

128510000(rab5if)

NGRA:

132895981(rab5if)

TRN:	134333495(rab5if)

AMEX:

103021550(rab5if)

CMAO:

118822984(rab5if)

EEE:	113588886(rab5if)

CHAR:

105904298(rab5if) 122130599

SPIL:

134087285(rab5if)

ASAD:

121713289(rab5if)

TRU:	101063564(rab5if)

TFS:	130530368(rab5if)

TNG:	GSTEN00033160G001

LCO:	104925093(rab5if)

NCC:

104964930

TBEN:

117479470(rab5if)

CGOB:

115011463(rab5if)

PGEO:

117449391(rab5if)

GACU:

117540732(rab5if)

EMAC:

134863287(rab5if)

ELY:	117258976(rab5if)

EFO:	125891975(rab5if)

PLEP:

121937856 121947191(rab5if)

SLUC:

116062127(rab5if)

ECRA:

117947500(rab5if)

ESP:	116692474(rab5if)

PFLV:

114558810(rab5if)

PPUG:

119223304(rab5if)

AFB:	129100005(rab5if)

PSWI:

130199956(rab5if)

CANA:

137799974(rab5if)

CVE:	137872238(rab5if)

MSAM:

119905409(rab5if)

SCHU:

122883781(rab5if)

CUD:	121517224(rab5if)

SPUL:

138589864(rab5if)

LMIX:

132989591(rab5if)

HTC:	141798798(rab5if)

ALAT:

119023443(rab5if)

ASTR:

137614100(rab5if)

MZE:	101470883(rab5if)

ONL:	100698115(rab5if)

OAU:	116334572(rab5if)

OLA:	101160978(c7h20orf24)

OML:	112159173(rab5if)

CSAI:

133457100(rab5if)

XMA:	102218936(c1h20orf24)

XCO:	114148406(rab5if)

XHE:	116728122(rab5if)

PRET:

103467477(clg7h20orf24)

PFOR:

103141863

PLAI:

106941313

PMEI:

106919050

GAF:	122829722(rab5if)

PPRL:

129370386(rab5if)

CVG:

107087607

CTUL:

119774158(rab5if)

GMU:	124877010(rab5if)

NFU:	107391019(csgr15h20orf24)

KMR:	108235175(rab5if)

ALIM:

106523699

NWH:	119416898(rab5if)

AOCE:

111576284(rab5if)

EJA:	138192835(rab5if)

BFRE:

138636856(rab5if)

MCEP:

125007135(rab5if)

CSEM:

103385457(c10h20orf24)

POV:	109635125(cunh20orf24)

SSEN:

122777506(rab5if)

SSOE:

131468007(rab5if)

HHIP:

117764826(rab5if)

HSP:	118111328(rab5if)

PPLT:

128442864(rab5if)

SMAU:

118316358(rab5if)

LCF:	108877901(rab5if)

SDU:	111219315(cunh20orf24)

SLAL:

111668899

XGL:	120803328(rab5if)

HCQ:	109514981(cunh20orf24)

SSCV:

125989233(rab5if)

SBIA:

133493765(rab5if)

PEE:	133399092(rab5if)

PTAO:

133467450(rab5if)

BPEC:

110164816(cunh20orf24)

ENY:	140363301(rab5if)

MALB:

109964623(cunh20orf24)

BSPL:

114859007(rab5if)

SJO:	128357778(rab5if)

SSCO:

133988384(rab5if)

TTY:	137184616(rab5if)

GMH:	115542491(rab5if)

SASA:

106566554(cssa13h20orf24)

STRU:

115168521(rab5if)

OTW:	112222316(rab5if)

OMY:	110492524(rab5if)

OGO:	124045016(rab5if)

ONE:	115102001(rab5if)

OKI:	109884811(rab5if)

OKE:	118371155(rab5if)

OMM:	135527874(rab5if)

OCLA:

139368893

SALP:

111976773(rab5if)

SNH:	120061430(rab5if)

SFON:

129861485(rab5if)

CCLU:

121537562 121546106(rab5if)

ELS:	105013962(rab5if)

OEP:	134018464(rab5if)

SFM:

108926428

PKI:	111835925(cunh20orf24)

AANG:

118207197(rab5if)

AROT:

135234224(rab5if)

CCOG:

133138757(rab5if)

PSPA:

121297752(rab5if) 121319327

ARUT:

117424627 117964517

PSEX:

120514879(rab5if)

LCM:

102363529

CMK:	103186290(rab5if)

CPLA:

122560251(rab5if)

HOC:	132822987(rab5if)

SCAU:

119955410 119969666(rab5if) 119971571 119973636

LERI:

129707275(rab5if)

HAKA:

140736180(rab5if)

PMRN:

116944077

LRJ:	133350789(RAB5IF)

BFO:

BBEL:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

PFLL:

DME:	Dmel_CG12107(CG12107)

DER:

6542666

DSE:

6608038

DSI:	Dsimw501_GD10503(Dsim_GD10503)

DYA:	Dyak_GE19142

DAN:

DSR:

DPO:

DPE:

DMN:	108160547 117191386

DWI:

6639806

DMO:	Dmoj_GI20383

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119680981 119682839

MDE:	101900374 131801613

SCAC:

106095790

LCQ:

111684901

LSQ:	119613107 119613301

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ011052

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

BMOR:

MSEX:

DPL:	KGM_212329

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113497728 113507829

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

LDA:

HVI:

MQU:

PHU:	Phum_PHUM468540

FOC:

TPAL:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

IEL:

HAMR:

DPX:	DAPPUDRAFT_304748

DMK:

DPZ:

AFRA:

PVM:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

TCF:	131881818 131882369

ISC:

DSV:

RSAN:

RMP:

OTI:

GOE:

CSCU:

CVS:

PTEP:

ABRU:

UDV:	129229935 129233933

SDM:

118197088

PMEO:

129587820

CEL:	CELE_F44E7.9(F44E7.9)

CBR:

CBG_09319

BMY:	BM_BM4090(Bm4090)

LOA:	LOAG_11502

HRO:	HELRODRAFT_78375

LGI:	LOTGIDRAFT_213830

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Reference

PMID:31536960

Authors

Moutaoufik MT, Malty R, Amin S, Zhang Q, Phanse S, Gagarinova A, Zilocchi M, Hoell L, Minic Z, Gagarinova M, Aoki H, Stockwell J, Jessulat M, Goebels F, Broderick K, Scott NE, Vlasblom J, Musso G, Prasad B, Lamantea E, Garavaglia B, Rajput A, Murayama K, Okazaki Y, Foster LJ, Bader GD, Cayabyab FS, Babu M

Title

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

Journal

iScience 19:1114-1132 (2019)
DOI:10.1016/j.isci.2019.08.057

Sequence

[hsa:55969]

LinkDB

DBGET integrated database retrieval system