KEGG   ORTHOLOGY: K26574
Entry
K26574                      KO                                     
Symbol
clbC
Name
colibactin biosynthesis polyketide synthase
Pathway
map01054  Nonribosomal peptide structures
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01054 Nonribosomal peptide structures
    K26574  clbC; colibactin biosynthesis polyketide synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K26574  clbC; colibactin biosynthesis polyketide synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  PKS-NRPS hybrid
   Bacterial type (modular)
    Colibactin synthetase
     K26574  clbC; colibactin biosynthesis polyketide synthase
Other DBs
COG: COG3321
Genes
ECP: ECP_1978
ECI: UTI89_C2221
EIH: ECOK1_2184
ECC: c2468
EAB: ECABU_c22790
ELU: UM146_07100
ELC: i14_2277
ELD: i02_2277
ECOI: ECOPMV1_02107(ppsE_4)
KPP: A79E_1664(clbC)
KPG: KPNIH32_17820
KPNK: BN49_3627(clbC)
EAR: CCG29231
CKO: CKO_00860
 » show all
Reference
PMID:16902142
  Authors
Nougayrede JP, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E
  Title
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.
  Journal
Science 313:848-51 (2006)
DOI:10.1126/science.1127059
  Sequence
[eih:ECOK1_2184]
Reference
PMID:35288725
  Authors
Tang JW, Liu X, Ye W, Li ZR, Qian PY
  Title
Biosynthesis and bioactivities of microbial genotoxin colibactins.
  Journal
Nat Prod Rep 39:991-1014 (2022)
DOI:10.1039/d1np00050k
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