KEGG ORTHOLOGY: K27001

ORTHOLOGY: K27001

Entry

K27001                      KO

Symbol

GDAH, AGMAT

Name

taurocyamine/4-guanidinobutanoate/3-guanidinopropanoate hydrolase [EC:3.5.3.- 3.5.3.7 3.5.3.17]

Pathway

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

Reaction

R01990

4-guanidinobutanoate amidinohydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K27001  GDAH, AGMAT; taurocyamine/4-guanidinobutanoate/3-guanidinopropanoate hydrolase
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.3  In linear amidines
    3.5.3.7  guanidinobutyrase
     K27001  GDAH, AGMAT; taurocyamine/4-guanidinobutanoate/3-guanidinopropanoate hydrolase
    3.5.3.17  guanidinopropionase
     K27001  GDAH, AGMAT; taurocyamine/4-guanidinobutanoate/3-guanidinopropanoate hydrolase

Other DBs

GO:	0047971 0047972

Genes

HSA:	79814(AGMAT)

PTR:	469130(AGMAT)

PPS:	100992228(AGMAT)

GGO:	101130794(AGMAT)

PON:	100459829(AGMAT)

PPYG:

129007024(AGMAT)

NLE:	100598086(AGMAT)

HMH:	116812960(AGMAT)

SSYN:

129472512(AGMAT)

MCC:	713190(AGMAT)

MCF:	102126199(AGMAT)

MTHB:

126929681

MNI:	105473216(AGMAT)

CSAB:

103225549(AGMAT)

CATY:

105599421(AGMAT)

PANU:

101010886(AGMAT)

TGE:	112606506(AGMAT)

MLEU:

105549437(AGMAT)

RRO:	104677699(AGMAT)

RBB:	108524267(AGMAT)

TFN:	117093251(AGMAT)

PTEH:

111527300(AGMAT)

CANG:

105510235(AGMAT)

CJC:	100409747(AGMAT)

SBQ:	101050462(AGMAT)

CIMI:

108286881(AGMAT)

ANAN:

105708590(AGMAT)

CSYR:

103260477(AGMAT)

MMUR:

105870443(AGMAT)

LCAT:

123635956(AGMAT)

ERUF:

138390464(AGMAT)

PCOQ:

105824869(AGMAT)

OGA:	100945637(AGMAT)

MMU:	75986(Agmat)

MCAL:

110293439(Agmat)

MPAH:

110323723(Agmat)

RNO:	298607(Agmat)

MCOC:

116095648(Agmat)

ANU:	117709324(Agmat)

ASYL:

127681575(Agmat)

MUN:	110545044(Agmat)

CGE:	100752066(Agmat)

MAUA:

101843966(Agmat)

PROB:

127213252(Agmat)

PLEU:

114700862(Agmat)

PMAV:

102906783(Agmat)

MORG:

121448548(Agmat)

MFOT:

126507579

AAMP:

119816983(Agmat)

CNL:	130884412(Agmat)

NGI:	103725333(Agmat)

HGL:	101705780(Agmat)

CPOC:

100714678(Agmat)

CCAN:

109692554(Agmat)

DORD:

105989953(Agmat)

DSP:	122099131(Agmat)

DMER:

138814803 138838017(Agmat)

PLOP:

125354226(Agmat)

NCAR:

124976952

MMMA:

107142214(Agmat)

ITI:	101963766(Agmat)

OCU:

100349292

OPI:	101526012(AGMAT)

OCZ:	121161365(AGMAT)

TUP:	102493899(AGMAT)

GVR:	103590592(AGMAT)

CFA:	487430(AGMAT)

CLUD:

112659929(AGMAT)

VVP:	112929774(AGMAT)

VLG:	121497297(AGMAT)

NPO:	129513407(AGMAT)

AML:	100483264(AGMAT)

UMR:	103666844(AGMAT)

UAH:	113270475(AGMAT)

UAR:	123777787(AGMAT)

ELK:

111154877

LLV:

125098081

MPUF:

101679911(AGMAT)

MNP:	132001563(AGMAT)

MLK:	131810054(AGMAT)

NVS:	122899482(AGMAT)

ORO:	101362207(AGMAT)

EJU:	114213416(AGMAT)

ZCA:	113937333(AGMAT)

MLX:	118019978(AGMAT)

LWW:	102727278(AGMAT)

FCA:	101083692(AGMAT)

PYU:	121021583(AGMAT)

PCOO:

112861765(AGMAT)

PBG:	122479965(AGMAT)

PVIV:

125172088(AGMAT)

LRUF:

124514690

LGF:	123597227(AGMAT)

AJU:

106975575

PTG:	102966834(AGMAT)

PPAD:

109274158(AGMAT)

PUC:

125913079

PLEZ:

122226562(AGMAT)

HHV:	120229778(AGMAT)

BTA:	514509(AGMAT)

BOM:	102279516(AGMAT)

BIU:	109570434(AGMAT)

BBUB:

102411139(AGMAT)

BKE:	129653191(AGMAT)

BBIS:

104996111(AGMAT)

CHX:	102171086(AGMAT)

OAS:	101110431(AGMAT)

BTAX:

128061710(AGMAT)

CSUM:

138090392(AGMAT)

ODA:	120880585(AGMAT)

CCAD:

122452033(AGMAT)

MREE:

136168500(AGMAT)

OVR:	110124971(AGMAT)

MBEZ:

129551381(AGMAT)

SSC:	100519548(AGMAT)

CFR:	102515445(AGMAT)

CBAI:

105070943(AGMAT)

CDK:	105107058(AGMAT)

VPC:	102537502(AGMAT)

BACU:

103010367(AGMAT)

BMUS:

118898486(AGMAT)

LVE:	103078007(AGMAT)

OOR:	101271930(AGMAT)

LALB:

132515208(AGMAT)

GMF:	115864247(AGMAT)

DDP:	132427412(AGMAT)

DLE:	111187109(AGMAT)

PCAD:

102992756(AGMAT)

PSIU:

116748453(AGMAT)

PPHC:

136135273(AGMAT)

NASI:

112402818(AGMAT)

ECB:	100054283(AGMAT)

EPZ:	103565015(AGMAT)

EAI:	106828006(AGMAT)

MYB:	102251018(AGMAT)

MYD:	102759206(AGMAT)

MMYO:

118676547(AGMAT)

MLF:	102429256(AGMAT)

MDT:	132231652(AGMAT)

MYUM:

139002903(AGMAT)

PKL:	118723546(AGMAT)

EFUS:

103292029(AGMAT)

MNA:	107531569(AGMAT)

DRO:	112299129(AGMAT)

SHON:

118986318(AGMAT)

AJM:	119049964(AGMAT)

PDIC:

114497936(AGMAT)

PHAS:

123831645(AGMAT)

MMF:	118626568(AGMAT)

PPAM:

129075585(AGMAT)

HAI:	109389379(AGMAT)

RFQ:	117027153(AGMAT)

PALE:

102878076(AGMAT)

PGIG:

120585779(AGMAT)

PVP:	105294411(AGMAT)

RAY:	107501818(AGMAT)

MJV:	108389628(AGMAT)

TOD:	119235141(AGMAT)

SARA:

101538068(AGMAT)

SFUM:

130031753(AGMAT)

SETR:

126006592(AGMAT)

LAV:	100656314(AGMAT)

TMU:

101354841

ETF:	101657934(AGMAT)

DNM:	101436954(AGMAT)

MDO:	100027134(AGMAT)

GAS:	123243104(AGMAT)

SHR:	100930697(AGMAT)

AFZ:

127555829

PCW:	110198797(AGMAT)

TVP:	118839722(AGMAT)

PBRV:

138153924(AGMAT)

MLAO:

141509109(AGMAT)

OAA:	100093512(AGMAT)

TACU:

119928170(AGMAT)

GGA:	373942(AGMAT)

PCOC:

116242608(AGMAT)

MGP:	100540815(AGMAT)

CJO:	107323421(AGMAT)

TPAI:

128085091(AGMAT)

LMUT:

125703398(AGMAT)

NMEL:

110408510(AGMAT)

APLA:

101794990(AGMAT)

AACU:

137843580(AGMAT)

ACYG:

106040126(AGMAT)

CATA:

118253242(AGMAT)

AFUL:

116497742(AGMAT)

TGU:	100227017(AGMAT)

LSR:	110472278(AGMAT)

SCAN:

103824335(AGMAT)

PMOA:

120499400(AGMAT)

OTC:	121343975(AGMAT)

PRUF:

121351374(AGMAT)

ATRC:

139600786(AGMAT)

GFR:	102034863(AGMAT)

FAB:	101808491(AGMAT)

OMA:	130261776(AGMAT)

PHI:	102104168(AGMAT)

PMAJ:

107213686(AGMAT)

CCAE:

111938502(AGMAT)

CCW:	104697552(AGMAT)

CBRC:

103616180(AGMAT)

ACOE:

138121420(AGMAT)

ETL:	114068718(AGMAT)

ZAB:	102072861(AGMAT)

ZLE:	135456817(AGMAT)

ACHL:

103807539(AGMAT)

SVG:	106856453(AGMAT)

MMEA:

130585072(AGMAT)

HRT:	120762330(AGMAT)

SATI:

136370785(AGMAT)

CCIC:

134052983(AGMAT)

FPG:	101915189(AGMAT)

FCH:	102054117(AGMAT)

CCRI:

104155678(AGMAT)

SHAB:

115617333(AGMAT)

ACUN:

113487965(AGMAT)

TALA:

104360602(AGMAT)

ACHC:

115343027(AGMAT)

HALD:

104319881(AGMAT)

HLE:	104837863(AGMAT)

AGEN:

126033947

HHAR:

128143672(AGMAT)

BBUT:

142030938(AGMAT)

GCL:

127024859

LDI:	104352038(AGMAT)

DPUB:

104305901(AGMAT)

PPUS:

135190423(AGMAT)

AVIT:

104278824(AGMAT)

BRHI:

104488895(AGMAT)

EGZ:	104133157(AGMAT)

NNI:	104011167(AGMAT)

PCRI:

104036300(AGMAT)

PADL:

103918065(AGMAT)

AFOR:

103907426(AGMAT)

FGA:	104079580(AGMAT)

CBOR:

142092498(AGMAT)

GSTE:

104255620(AGMAT)

CBOY:

140661666(AGMAT)

MAME:

142418545(AGMAT)

CNIC:

135997584(AGMAT)

MUI:	104542065(AGMAT)

PGUU:

104467953(AGMAT)

PLET:

104618167(AGMAT)

EHS:	104507546(AGMAT)

CMAC:

104484406(AGMAT)

CUCA:

104060573(AGMAT)

TEO:	104378969(AGMAT)

BREG:

104637092(AGMAT)

OHA:	104336693(AGMAT)

ACAR:

104522634(AGMAT)

CPEA:

104395421(AGMAT)

CVF:	104290817(AGMAT)

RTD:	128918293(AGMAT)

CRID:

134524292(AGMAT)

LMIC:

141732203(AGMAT)

AAM:	106493416(AGMAT)

AROW:

112966847(AGMAT)

NPD:	112959564(AGMAT)

TGT:	104569141(AGMAT)

DNE:	112988469(AGMAT)

SCAM:

104153651(AGMAT)

ASN:	102387402(AGMAT)

AMJ:	102575143(AGMAT)

CPOO:

109314377(AGMAT)

GGN:	109293787(AGMAT)

PSS:	102443768 102446543

CIZ:	142001044 142025622

CMY:	102935030(AGMAT)

CCAY:

125624446(AGMAT)

LKP:	140900020 140900021

NDS:	142000844(AGMAT)

DCC:	119845039(AGMAT)

CPIC:

101943383(AGMAT)

TST:	117867818(AGMAT)

CABI:

116824354(AGMAT)

MRV:	120387757(AGMAT)

ASAO:

132764694(AGMAT)

PVT:	110070862(AGMAT)

SUND:

121936231(AGMAT)

PBI:	103059727(AGMAT)

PMUR:

107291359(AGMAT)

CTIG:

120319037(AGMAT)

TSR:	106547435(AGMAT)

PGUT:

117669672(AGMAT)

PCAE:

139325961(AGMAT)

APRI:

131186953(AGMAT)

VKO:	123034727(AGMAT)

PMUA:

114602390(AGMAT)

PRAF:

128419611(AGMAT)

ZVI:	118086142(AGMAT)

HCG:	128338454(AGMAT)

GJA:	107124455(AGMAT)

STOW:

125445631(AGMAT)

EMC:	129345047(AGMAT)

XLA:	108696868(agmat.L) 734257(agmat.S)

XTR:	108645262 496991(agmat)

NPR:	108788405(AGMAT)

RTEM:

120915931(AGMAT)

ACAT:

141110255(AGMAT)

PADS:

140340734(AGMAT)

BBUF:

120994137(AGMAT)

BGAR:

122927055(AGMAT)

DTC:	141085160(AGMAT)

PWL:	138300652(AGMAT)

MUO:	115456666(AGMAT)

GSH:	117349106(AGMAT)

DRE:	556522(agmat)

SRX:

107714919

SANH:

107664256(agmat)

SGH:	107576289 107599515

CCAR:

109082418(agmat)

CAUA:

113041194(agmat)

CGIB:

128011206

PTET:

122328974

LROH:

127154797(agmat)

GRF:	141290425(agmat)

OMC:	131531777(agmat)

PPRM:

120463603(agmat)

RKG:	130090593(agmat)

MAMB:

125259839(agmat)

CIDE:

127505539

CERY:

137009247(agmat)

MASI:

127419996

TROS:

130571910(agmat)

TDW:	130408978(agmat)

MANU:

129430783(agmat)

PDAB:

135775219(agmat)

IPU:

108275847

IFU:	128619218(agmat)

PHYP:

113530354(agmat)

SMEO:

124399129(agmat)

TFD:	113641892(agmat)

TVC:	132862043(agmat)

CGAR:

128509958(agmat)

NGRA:

132896069(agmat)

TRN:

134333060

AMEX:

103044008(agmat)

CMAO:

118822162(agmat)

EEE:	113570292(agmat)

CHAR:

105912671 105912720

SPIL:

134087578(agmat)

ASAD:

121713963(agmat)

TRU:	105419112(agmat)

TFS:	130529780(agmat)

TNG:	GSTEN00008256G001 GSTEN00023371G001

LCO:	104928636(agmat)

NCC:

104957503

TBEN:

117469660 117470991 117475757 117491161

PGEO:

117440992 117440993

GACU:

117546988(agmat)

EMAC:

134862304(agmat)

ELY:	117257961(agmat)

EFO:	125891900(agmat)

PLEP:

121946945(agmat)

SLUC:

116043722(agmat)

ECRA:

117947119(agmat)

ESP:	116691969(agmat)

PFLV:

114559066(agmat)

GAT:	120828750(agmat)

PPUG:

119223359(agmat)

AFB:	129100152(agmat)

CLUM:

117733873(agmat)

PSWI:

130200035(agmat)

CANA:

137800704(agmat)

CVE:	137889083(agmat)

MSAM:

119905161(agmat)

SCHU:

122883694(agmat)

EARM:

139288565(agmat)

CUD:	121517707(agmat)

SPUL:

138590107(agmat)

LMIX:

132989997(agmat)

HTC:	141799564(agmat)

ALAT:

119022793(agmat)

ASTR:

137610922(agmat)

PKLU:

139209873(agmat)

MZE:	101472763(agmat)

ONL:	100705651(agmat)

OAU:	116321956(agmat)

OLA:	101159353(agmat)

OML:	112158624(agmat)

CSAI:

133456672(agmat)

XMA:	102224310(agmat)

XCO:	114140469(agmat)

XHE:	116716988(agmat)

PRET:

103467816(agmat)

PFOR:

103156801(agmat)

PLAI:

106950829(agmat)

PMEI:

106921824(agmat)

GAF:	122833948(agmat)

PPRL:

129377205(agmat)

CVG:	107091594(agmat)

CTUL:

119784985(agmat)

GMU:	124877509(agmat)

NFU:	107390416(agmat)

KMR:	108237583 108237584

ALIM:

106529074(agmat)

NWH:	119416615 119416616

AOCE:

111562735(agmat)

EJA:	138193384(agmat)

BFRE:

138628109(agmat)

MCEP:

125003554(agmat)

CSEM:

103385275(agmat)

POV:	109640817(agmat)

SSEN:

122776714(agmat)

SSOE:

131468707(agmat)

HHIP:

117764344(agmat)

HSP:	118111292(agmat)

PPLT:

128442737(agmat)

SMAU:

118317341(agmat)

LCF:	108888648 108889098(agmat)

SDU:	111235063(agmat)

SLAL:

111662177 111669359(agmat)

XGL:	120804401(agmat)

HCQ:	109520226(agmat)

SSCV:

125987729(agmat)

SBIA:

133512582(agmat)

PEE:	133414077(agmat)

PTAO:

133465491(agmat)

BPEC:

110159402(agmat)

ENY:	140362414(agmat)

MALB:

109951221(agmat)

BSPL:

114859277(agmat)

SJO:	128357822(agmat)

SSCO:

133987560(agmat)

TTY:	137184965(agmat)

GMH:	115546789(agmat)

SASA:

106572552(agmat)

STRU:

115165631(agmat)

OTW:

112216275

OMY:	110532583(agmat)

OGO:

124032181

ONE:

115132419

OKI:	109908227(agmat)

OKE:	118360762(agmat)

OMM:	135504135(agmat)

OCLA:

139416731

SALP:

111976417(agmat)

SNH:	120059172(agmat)

SFON:

129829805(agmat)

CCLU:

121537995(agmat)

ELS:	105028693(agmat)

OEP:	134018722(agmat)

SFM:	108939182(agmat)

PKI:	111855766(agmat)

AANG:

118207856(agmat)

AROT:

135234567(agmat)

CCOG:

133138278(agmat)

LOC:	102691972(agmat)

PSPA:

121329076

ARUT:

117425432 117426072 117972142

PSEX:

120530943(agmat)

LCM:	102355891(AGMAT)

CMK:	103187649(agmat)

RTP:	109927822(agmat)

CPLA:

122540286(agmat)

CPUN:

140487084(agmat)

HOC:	132833510(agmat)

SCAU:

119950610(agmat)

LERI:

129711509(agmat)

HAKA:

140718312(agmat)

PMRN:

116950419(AGMAT)

LRJ:	133352523(AGMAT)

BFO:

118427765

BBEL:

109477815

CIN:	100177356 100180543

SCLV:

120344585 120347203

CLEP:

143465730 143466108 143471043

SPU:	115922593 115922594 115922848 577889 590928

LPIC:

129278510 129278757 129279689

LVG:	121429850 121430234 121430408

AJJ:

139960965

APLC:

110981765 110988417 110988422

ARUN:

AAMU:

AFIL:

AJC:

SKO:	100368327 100372203

PFLL:

139116903 139117952

PVM:

113803960

PJA:	122252527 122252528

PCHN:

125033498 125033512

PMOO:

119577610 119577611 119577944

HAME:

121868770 121868772

PCLA:

123750882 123766570

CQD:	128691210 128691212 128691213

PTRU:

123506361 123519636

ESN:	126983900 126994231

MNZ:

135213857

MRJ:	136836082 136836589

PORN:

139750949 139765299

OOT:	143022107 143027838

DSV:

DALB:

RSAN:

RMP:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

LGI:	LOTGIDRAFT_142007

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:	121386796 121388634

HRF:	124118721 124139513

HRJ:	124258984 124259003 124262784

HASI:

137278062 137278063 137282458

HCRA:

139447347 139455526

CRG:

105344283

CANU:

128180792

CVN:	111133872 111135347

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

LJP:

LAK:	106167048 106182048

LLON:

135496067

NVE:	5509339 5512891

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

HSY:

RES:	135683053 135683426

» show all

Reference

PMID:36543883

Authors

Sinn M, Stanoppi M, Hauth F, Fleming JR, Funck D, Mayans O, Hartig JS

Title

Guanidino acid hydrolysis by the human enzyme annotated as agmatinase.

Journal

Sci Rep 12:22088 (2022)
DOI:10.1038/s41598-022-26655-4

Reference

PMID:11804860

Authors

Mistry SK, Burwell TJ, Chambers RM, Rudolph-Owen L, Spaltmann F, Cook WJ, Morris SM Jr

Title

Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus.

Journal

Am J Physiol Gastrointest Liver Physiol 282:G375-81 (2002)
DOI:10.1152/ajpgi.00386.2001

Sequence

[hsa:79814]

LinkDB

DBGET integrated database retrieval system