KEGG   ORTHOLOGY: K27305
Entry
K27305            Tight     KO                                     
Symbol
aprG, curF
Name
polyketide synthase / 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K27305  aprG, curF; polyketide synthase / 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.125  4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase
     K27305  aprG, curF; polyketide synthase / 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  beta-Branched incorporating proteins
   K27305  aprG, curF; polyketide synthase / 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase
Other DBs
COG: COG3321 COG0604 COG1024 COG0236
Genes
MPRO: BJP34_29095
AG: WLM68693(aprG)
Reference
PMID:21533272
  Authors
Grindberg RV, Ishoey T, Brinza D, Esquenazi E, Coates RC, Liu WT, Gerwick L, Dorrestein PC, Pevzner P, Lasken R, Gerwick WH.
  Title
Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage.
  Journal
PLoS One 6:e18565 (2011)
DOI:10.1371/journal.pone.0018565
  Sequence
[ag:WLM68693]
Reference
PMID:17928301
  Authors
Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Hakansson K, Sherman DH, Smith JL.
  Title
Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.
  Journal
J Biol Chem 282:35954-63 (2007)
DOI:10.1074/jbc.M703921200
  Sequence
[mpro:BJP34_29095]
LinkDB

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