ORTHOLOGY: K27792
Help
Entry
K27792 KO
Symbol
PAS
Name
precondylocarpine acetate synthase [EC:
1.21.3.11
]
Pathway
map00901
Indole alkaloid biosynthesis
map01100
Metabolic pathways
map01110
Biosynthesis of secondary metabolites
Module
M00965
Vinblastine biosynthesis, geissoschizine => vinblastine
Reaction
R13344
stemmadenine acetate:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09110 Biosynthesis of other secondary metabolites
00901 Indole alkaloid biosynthesis
K27792 PAS; precondylocarpine acetate synthase
Enzymes [BR:
ko01000
]
1. Oxidoreductases
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.3 With oxygen as acceptor
1.21.3.11 precondylocarpine acetate synthase
K27792 PAS; precondylocarpine acetate synthase
BRITE hierarchy
Genes
AG:
AWJ76616
(PAS)
Taxonomy
UniProt
Reference
PMID:
29724909
Authors
Caputi L, Franke J, Farrow SC, Chung K, Payne RME, Nguyen TD, Dang TT, Soares Teto Carqueijeiro I, Koudounas K, Duge de Bernonville T, Ameyaw B, Jones DM, Vieira IJC, Courdavault V, O'Connor SE
Title
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.
Journal
Science 360:1235-1239 (2018)
DOI:
10.1126/science.aat4100
Sequence
[ag:
AWJ76616
]
LinkDB
All DBs
DBGET
integrated database retrieval system