KEGG ORTHOLOGY: K28228

ORTHOLOGY: K28228

Entry

K28228                      KO

Symbol

scdL1, ipdA

Name

COCHEA-CoA hydrolase alpha subunit [EC:4.1.-.-]

Pathway

map00984

Steroid degradation

map01120

Microbial metabolism in diverse environments

Reaction

R13482

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K28228  scdL1, ipdA; COCHEA-CoA hydrolase alpha subunit

Other DBs

COG:

COG1788

Genes

RGL:	CS053_01805

VAF:	D1115_22665

PRE:	PCA10_13390

PFUW:

PLAL:

PPUT:

PPUN:

PPUU:

PKC:

PFZ:	AV641_10720

PLQ:	AA042_19965

PPSY:

AOC04_08025

PSET:

THL1_1411

PSIL:

PMA3_11805

PKE:	DLD99_14640

PUM:	HGP31_20695

PPSH:

G5J76_13975

PAZE:

KSS91_19155

PTAE:

NCTC10697_02093(gctA)

PCAV:

D3880_17220

PPHN:

HU825_14505

PIZ:	LAB08_R40720

PKM:	PZ739_11715

PSHS:

PFOU:

PSKP:

PDEU:

PBUB:

PSML:

PSMZ:

PSWO:

PMOR:

PSAO:

PKH:	JLK41_05800

SDEG:

HARR:

PPHA:

HASM:

KAK:	Kalk_07820

SPL:

SHL:

COLW:

CBER:

PHA:

PTN:	PTRA_a1033(gctA)

PNG:	PNIG_a1085(gctA)

SNAN:

I6N98_06935

ZAL:	AZF00_05275

MSPN:

M8T91_14330

HALC:

EY643_14260

KIM:	G3T16_13745

AFUS:

EYZ66_12940

PAQM:

E0F26_07500

MSEC:

LN244_05125

MRZ:	KDW95_01130

ENW:	MJO57_22795

EMP:	EZMO1_1286(atoD)

SDF:	ACG33_00310

SOK:	D0B54_05285

SINI:

GT972_08455

FCE:	JN531_005445

GPB:	HDN1F_27380

RIN:	ACS15_4383

REH:	H16_B0655(h16_B0655)

CNC:	CNE_2c06020

CUH:	BJN34_30710

REU:	Reut_A1558

CTI:	RALTA_B0497(gctA)

CBW:	RR42_s2335

COX:	E0W60_08220

CUK:	KB879_20720

CUPP:

CTP10_R38860

CUPA:

LPA45_23995

BUR:	Bcep18194_B1432

BCJ:

BCEN:

BCEO:

BCT:

BCED:

BCEP:

BPYR:

BCON:

BDF:	WI26_21315

BTEI:

BPSL:

BMEC:

BSTL:

BANN:

BARI:

BAEN:

BURK:

BURF:

BFN:

PBRY:

PPAI:

PVE:	UC34_06940

CABA:

SBC2_48820

CTT:	CtCNB1_1276

CTES:

O987_07290

CRJ:	QMY55_06800

DIH:	G7047_10910

SMIO:

CATMQ487_32160

DOE:	DENOEST_1366

DENI:

B9N43_04465

AZD:	CDA09_09625

THU:	AC731_008510

THAU:

C4PIVTH_4231

THAG:

CKCBHOJB_02321

MESS:

ABSY17_13440

AAK:	AA2016_3653

AMIS:

Amn_27930

AMIO:

N7E70_017855

GYJ:	AADW23_16450

FRB:	AB6B37_08165

NAR:

Saro_3751

NPP:	PP1Y_Mpl3056

NOV:	TQ38_027270

NOT:	C7W88_20755

NOR:	FA702_21045

NOVO:

IM701_18090 IM701_20475

SPHM:

SPHI:

SSAN:

SPKC:

SPHA:

SLAN:

SBIN:

SPCL:

SPSO:

SPOG:

SWI:	Swit_2072 Swit_3297

SPHD:

HY78_09065 HY78_15155

SPHB:

EP837_03389(gctA)

SPCA:

GL174_15745

PHAO:

HF685_05545

CNA:	AB433_04795

PHZ:	CHX26_05290

NTD:	EGO55_13705

CAEN:

K5X80_14710

HFO:	ABFZ83_09710

ACYC:

JI721_14720

SAY:

TPY_1605

SAP:	Sulac_1807

MTU:

MTV:

MTC:

MRA:

MTF:	TBFG_13584

MTB:	TBMG_03590

MTK:	TBSG_03617

MTZ:	TBXG_003566

MTI:	MRGA423_22445

MTE:	CCDC5079_3292

MTUR:

CFBS_3767

MTL:	CCDC5180_3244

MTO:	MTCTRI2_3615

MTD:

UDA_3551

MTN:	ERDMAN_3896

MTJ:	J112_19115

MTUB:

MT7199_3613

MTUC:

J113_24835

MTUE:

J114_18990

MTX:	M943_18255

MTUL:

TBHG_03491

MTUT:

HKBT1_3752

MTUU:

HKBT2_3761

MTQ:	HKBS1_3764

MBO:	BQ2027_MB3581

MBB:

BCG_3615

MBT:

JTY_3616

MBM:	BCGMEX_3613

MBK:	K60_036890

MBX:

BCGT_3417

MAF:

MAF_35630

MMIC:

RN08_3927

MCE:	MCAN_35621

MCQ:	BN44_110043

MCV:	BN43_90049

MCX:	BN42_90046

MCZ:	BN45_100046

MORY:

MPA:

MAO:

MAVI:

MAVU:

MAV:

MAVM:

MAA44156_00528(gctA)

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MSER:

MSA:	Mycsm_05816

MUL:

MUL_4114

MMI:

MMAR_5040

MMAE:

MMARE11_48500

MLI:	MULP_05293

MPSE:

MSHO:

MMC:

MKM:

MJL:

MMM:

MKN:	MKAN_11940

MYV:	G155_26225

MYE:	AB431_26455

MHAD:

B586_04545

MDX:	BTO20_31450

MSHG:

MSG_04538

MFJ:	MFLOJ_40850

MSTO:

MSTO_44820

MSIM:

MSIM_29270

MSAK:

MSAS_28950

MKU:	I2456_25590

MLW:	MJO58_24995

MXE:	MYXE_05980

MNV:	MNVI_12350

MPAG:

C0J29_27635

MNM:	MNVM_23680

MGOR:

H0P51_25715

MCOO:

MCOO_27060

MBAI:

MB901379_04430(gctA)

MSEO:

MSEO_34330

MHEK:

JMUB5695_00496

MGAU:

MGALJ_38270

MLJ:	MLAC_47560

MBRD:

MSHJ:

MMAM:

MSPG:

MOT:	LTS72_28020

MPAA:

MKK62_02510

MKY:	IWGMT90018_57260

MADI:

A7U43_06845

MWU:	PT015_15460

MYJ:	BCA37_02825

MHAF:

ACEL92_03085(ipdA)

MSM:	MSMEG_6002

MSG:	MSMEI_5841

MSB:	LJ00_29675

MSN:	LI99_29680

MSH:	LI98_29685

MVA:

Mvan_5267

MAUS:

JN090_26415

MGI:

Mflv_1489

MSP:	Mspyr1_46780

MCB:	Mycch_4645

MNE:	D174_24545

MYN:	MyAD_24080

MFT:	XA26_53150

MPHL:

MPHLCCUG_00525(gctA)

MVQ:

MYVA_5181

MLL:	B1R94_25295

MRH:	MycrhN_2278

MTHN:

4412656_04069(gctA)

MHAS:

MHAS_03747

MDU:	MDUV_49300

MCHT:

MCHIJ_19610

MAUU:

NCTC10437_05021(gctA)

MMAG:

MMAD_48350

MMOR:

MMOR_12110

MFX:	MFAL_32910

MAIC:

MAIC_05400

MIJ:	MINS_00370

MALV:

MALV_42500

MTY:	MTOK_22230

MPSC:

MARZ:

MGAD:

MHEV:

MSAR:

MANY:

MAUB:

MPOF:

MPHU:

MMUC:

MMAT:

MBOK:

MFG:	K6L26_05565

MSEI:

MSEDJ_02250

MFLV:

NCTC10271_00491(gctA)

MCEE:

MCEL_38030

MMON:

EWR22_25345

MGO:	AFA91_10780

MHOL:

K3U96_03205

MSEN:

K3U95_25270

MPAE:

K0O64_25950

MRF:	MJO55_24010

MDF:	K0O62_25800

MCRO:

MGRO:

MFRE:

MBUG:

MYQ:	TUM20985_06650

MFLU:

HZU40_32890

MYH:	QU592_27220

MPAT:

MPNTM1_01950

MWJ:	ACOI2T_03935(ipdA)

MYCE:

ACRDU6_29375

MKR:	MKOR_35590

MPAK:

MIU77_02095

MAB:

MAB_0605c

MMV:	MYCMA_12600

MABB:

MASS_0575

MABL:

MMASJCM_0594

MCHE:

BB28_02895

MIZ:	BAB75_03645

MSTE:

MSTE_00564

MSAO:

MYCSP_02595

MSAL:

DSM43276_00523(gctA)

MYY:	RHO23_23860

MJD:	JDM601_3705

MTER:

4434518_03705(gctA)

MMIN:

MMIN_12290

MHIB:

MHIB_30960

MHER:

K3U94_20905

MVM:	MJO54_20805

MKK:	MU0083_003452

ASD:

AS9A_0957

NFA:

NFA_5090

NFR:	ERS450000_03723(gctA)

NCY:	NOCYR_0522

NBR:	O3I_002825

NNO:	NONO_c05240

NSL:	BOX37_02285

NSR:	NS506_01289(gctA)

NTP:	CRH09_03430

NOZ:	DMB37_23725

NOD:	FOH10_28545

NAH:	F5544_02760

NAD:	NCTC11293_01270(gctA)

NWL:	NWFMUON74_05180

NIE:	KV110_03145

NTC:	KHQ06_03505

NHU:	H0264_03990

NYA:	LTV02_28750

NGP:	LTT66_15640

NSPU:

IFM12276_02020

NYU:	D7D52_04640

NVU:	V7968_10240

RHA:	RHA1_ro04651

RER:

RER_09190

REY:

O5Y_04090

REB:	XU06_04335

RQI:	C1M55_04570 C1M55_18940

ROP:

ROP_47490

ROA:	Pd630_LPD01153

RPY:	Y013_19200

RBY:	CEJ39_05565

RAET:

JQ505_27240

RHW:	BFN03_14785

RRZ:	CS378_19735

RHOD:

AOT96_14975 AOT96_29570

RRT:	4535765_00616(gctA)

RCR:	NCTC10994_02105(gctA)

RTM:	G4H71_07215

RKO:	JWS14_25650

RGO:	KYT97_14655

ROZ:	CBI38_04820

RPSK:

JWS13_18740

RGOR:

NMQ04_02685

RHOP:

D8W71_08035

RHOO:

RA302_04440 RA302_18440

RHOU:

KZJ41_04095

RHOW:

A4U64_20675

RHOJ:

JVH1_12995(ipdA)

RHOS:

RHOQ:

RHOY:

RHOH:

RHOX:

RHJS:

RSF:	OED52_02445

RHZQ:

RHZG:

RHBH:

RHPD:

RHON:

EHW12_04340 EHW12_18905

RHWB:

RHSQ:

RHWY:

RHDM:

RHWQ:

RHMM:

RHZP:

RHRC:

P0M12_01160 P0M12_16790

RHNY:

ACBG85_04555(ipdA)

RHRD:

RDE2_05300

RHDK:

PST05_23755(ipdA)

RHMZ:

QWU03_22100

RIO:	ACM26Y_03620(ipdA)

RHDE:

PSR88_23650(ipdA)

REQ:	REQ_00850 REQ_07170

PSOW:

ABI214_10055(ipdA) ABI214_13590

WHR:	OG579_09380

GBR:

Gbro_3982

GPO:	GPOL_c43040

GOR:	KTR9_3914(ipdA)

GOQ:	ACH46_17560

GTA:	BCM27_20515

GOC:	CXX93_00595

GIT:	C6V83_03870

GRU:	GCWB2_20010(gctA)

GOM:	D7316_04501

GAV:	C5O27_08105

GOD:	GKZ92_18935

GOS:	QAD21_19420

GOJ:	GR168_18765

GAM:	GII34_18915

GPD:	GII33_03830

GJI:	H1R19_18865

GOI:	LK459_13745

GHN:	MVF96_19450

GAMI:

IHQ52_22990

GMG:	NWF22_06430

GSI:	P5P27_01135

GOO:	HUN08_15905

GOP:	ACE11G_15670

GON:	Q9K23_16690

SPIN:

KV203_17230

TPR:

Tpau_3827

TSM:	ASU32_21810

TPUL:

TPB0596_41680

TSD:	MTP03_43110

DTM:	BJL86_0729

DIT:	C3V38_09370

DIZ:	CT688_03290

DPC:	A6048_03240

DLU:	A6035_03530

DKN:	NHB83_03100

DCD:	VYL96_03315

DID:	GJR88_01069

TOY:	FO059_13860

SMA:	SAVERM_6202(cotA)

SGR:

SGB:

SFI:

SANL:

SGRF:

SCYE:

SCB:	SCAB_68721

SVL:	Strvi_4081

SRC:	M271_44250

SMAL:

SAUO:

SSOI:

SANT:

SBH:

SVE:

SDV:	BN159_6437

SCI:	B446_10570

SVT:	SVTN_35835

STRE:

GZL_01198

SLD:

T261_0443

SLC:	SL103_15025

STRM:

M444_10245

SPRI:

SPRI_5498

SCZ:	ABE83_27945

SCX:	AS200_32875

SRW:	TUE45_02542(gctA)

SCLF:

BB341_21990

SGS:	AVL59_37050

STSI:

A4E84_00880

SALW:

CP975_30880

SGM:	GCM10017557_61970

SCAD:

DN051_28325

SPHW:

NFX46_30860

SLS:	SLINC_2344

SNR:	SNOUR_05105

SALU:

SALL:

SPLU:

SSIA:

SPUN:

SGV:	B1H19_37145

SLAU:

SLA_1556

SALF:

SMD44_07227

SALJ:

SMD11_0775

SLX:	SLAV_27320(gctA)

STRO:

STRMOE7_04805

SFK:

KY5_7033c

SNZ:	DC008_08445

SGE:	DWG14_08122

SRJ:

SRO_5452

SLK:	SLUN_09830

SDX:	C4B68_30135

SGD:	ELQ87_29250

SQZ:	FQU76_06670

SCYA:

EJ357_11860

STIR:

DDW44_03310

SKA:	CP970_04895

SGZ:	C0216_23130

SVN:	CP980_24860

SNK:	CP967_03030

SHAW:

CEB94_10920

SRK:	FGW37_28065

SFIC:

EIZ62_25065

SGAL:

CP966_08910

SSPO:

DDQ41_02680

SFY:	GFH48_29885

SAQU:

EJC51_13630

SGF:	HEP81_05759

SCAV:

SRIM:

SSUB:

SPHV:

STSU:

SCHA:

SGX:	H4W23_38470

SCOE:

CP976_11695

SSPB:

CP982_33810

SNF:	JYK04_02668

SPLA:

SBRO:

STUI:

SATA:

SHUN:

SCYG:

S1361_11130(gctA)

SFEU:

IM697_11840

SDW:	K7C20_03220

SAUH:

SU9_002435

SPEU:

CGZ69_33790

SROI:

IAG44_03050

SXN:	IAG42_26700

SHK:	J2N69_32375

SANU:

K7396_32205

SGOB:

test1122_18935

SINE:

KI385_05745

SLF:	JEQ17_34420

SDEC:

SAOV:

SDUR:

SYAN:

SRUG:

SAKB:

STAA:

SNIG:

SCAE:

STUB:

SSPN:

SCIR:

SXT:	KPP03845_102235

STUD:

STRTU_006621

SGK:	PET44_08865

SYUN:

MOV08_04840

SJN:	RI060_31910

SCYN:

N8I84_11275

SOV:	QZH56_03645

SFIY:

F0344_28345

SHAU:

K9S39_08205

SKG:	KJK29_28860

SCOA:

QU709_32735

SLAI:

P8A22_33580

SROC:

RGF97_25980

SFP:	QUY26_06105

STTN:

BSL84_08705

SINN:

ABB07_34055

KBU:	Q4V64_12685

SLUO:

STPB:

SRPA:

SMIB:

SCAJ:

STRW:

STRL:

STSD:

SRPZ:

SCHE:

SCAT:

STII:

STIC:

SABD:

SPAZ:

SMOD:

SPOF:

STBR:

STAC:

STVB:

SSOC:

SSLI:

STYI:

C9F11_32945(catI)

SCIT:

SSIR:

SEXP:

SFLU:

SSTO:

STGO:

STCM:

STID:

STCZ:

STSG:

STHU:

STRQ:

SSEC:

SHUG:

STRK:

STJL:

STHP:

STRX:

STFI:

STPG:

C1703_09355(gctA)

STPJ:

R1Y80_07695

SBON:

ACNNMR_02630

SCT:

SCAT_5625

SCY:	SCATT_56260

KAB:	B7C62_06825

YIA:	LO772_20225

STRH:

GXP74_18320

AGLA:

OIE69_15345

MRN:	K8F61_15890

MSUF:

KV394_02735

MWN:	QNO26_01520 QNO26_01590

MICJ:

LRQ07_15355 LRQ07_15440

ARL:	AFL94_16455

ARY:	ATC04_01415

ASUN:

KG104_08930

ARTA:

OL239_10545

GPR:	JQN66_16770

PAEY:

KUF55_17845

NCA:

Noca_2744

NDK:	I601_0611(catI)

NBE:	Back2_27600

NANO:

G5V58_09885

NARO:

CFH99_13420

NPI:	G7071_15850

NPC:	KUV85_04360

NMAR:

HPC71_09625

NFC:	KG111_08425

NBI:	SHK19_12365

NOF:	MF408_21170

NOCR:

OSR43_09670

NOCW:

ABFU82_07435 ABFU82_23110

NOCA:

ncot_09630

NOCL:

KM427_12655

NOCD:

QJ852_14400

NOCQ:

QI633_11995 QI633_24870

NOCS:

ACUP6Y_11235

PSIM:

KR76_14365 KR76_25105

AEB:	C6I20_03380

NGV:	CDO52_10835

TCU:

ACTW:

AMAZ:

ACIR:

AWS:	ACN3XK_35765 ACN3XK_36385

SPIQ:

OHA34_37850

ACTQ:

OG417_40400

SRO:

Sros_2064

NOA:	BKM31_34340

NCX:	Nocox_09770(gctA)

NGN:	LCN96_11030

NFS:	OIE67_36000

FRI:	FraEuI1c_1920

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_26225

AMQ:	AMETH_4465

AMYC:

CU254_23975

AMYB:

BKN51_05210

AAB:	A4R43_15955

AMYY:

YIM_33205(catI3)

AORI:

AACD:

APRT:

AROO:

ATHM:

ARHD:

AMOG:

ACYN:

ACOR:

AMYZ:

ANW:	QP939_44015

AMYD:

ABAR:

AMYE:

AMYS:

PSDS:

KAL:

KUT:	JJ691_41370

KBR:	Q4V65_07750

KPHY:

AOZ06_42550

LED:	BBK82_38840

LXR:	ACRSBM_25930

ALO:

PMAD:

SACE:

CROS:

STP:	Strop_2605

SAQ:

Sare_2804

MICB:

MicB006_5693

MCHL:

PVK74_03235

AMS:	AMIS_21690

AIH:	Aiant_18400

ACTL:

L3i22_084030

ASIC:

Q0Z83_065030

AOU:	ACTOB_004185

ACTE:

ACTI_41590

DVC:	Dvina_21490

DMAT:

Dmats_17120

DFU:	Dfulv_25855

DROS:

DAUR:

DACT:

CAI:

JCY:	M6B22_17365

ABAI:

IMCC26256_111851

CWO:

Cwoe_2354

AQZ:	KSP35_09515

ADAE:

ACE2AJ_17015

IAM:	HC251_18145

IMA:	PO878_16980

DHI:	LH044_15600

AHAI:

AB8619_00270

LEPV:

J4558_08955

» show all

Reference

PMID:12676694

Authors

Horinouchi M, Hayashi T, Koshino H, Yamamoto T, Kudo T

Title

Gene encoding the hydrolase for the product of the meta-cleavage reaction in testosterone degradation by Comamonas testosteroni.

Journal

Appl Environ Microbiol 69:2139-52 (2003)
DOI:10.1128/AEM.69.4.2139-2152.2003

Sequence

[ctt:CtCNB1_1276]

Reference

PMID:30194104

Authors

Horinouchi M, Koshino H, Malon M, Hirota H, Hayashi T.

Title

Steroid Degradation in Comamonas testosteroni TA441: Identification of Metabolites and the Genes Involved in the Reactions Necessary before D-Ring Cleavage.

Journal

Appl Environ Microbiol 84:e01324-18 (2018)
DOI:10.1128/e01324-18

Reference

PMID:29581275

Authors

Crowe AM, Workman SD, Watanabe N, Worrall LJ, Strynadka NCJ, Eltis LD.

Title

IpdAB, a virulence factor in Mycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase.

Journal

Proc Natl Acad Sci U S A 115:E3378-E3387 (2018)
DOI:10.1073/pnas.1717015115

Sequence

[mtu:Rv3551]

LinkDB

DBGET integrated database retrieval system