KEGG ORTHOLOGY: K28362

ORTHOLOGY: K28362

Entry

K28362                      KO

Symbol

THUMPD3

Name

tRNA (guanine(6/7)-N(2))-methyltransferase [EC:2.1.1.256 2.1.1.-]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis
    K28362  THUMPD3; tRNA (guanine(6/7)-N(2))-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.256  tRNA (guanine6-N2)-methyltransferase
     K28362  THUMPD3; tRNA (guanine(6/7)-N(2))-methyltransferase
Transfer RNA biogenesis [BR:ko03016]
Eukaryotic type
  tRNA modification factors
   Methyltransferases
    K28362  THUMPD3; tRNA (guanine(6/7)-N(2))-methyltransferase

Other DBs

GO:	0160117 0160118

Genes

HSA:	25917(THUMPD3)

PTR:	460147(THUMPD3)

PPS:	100988784(THUMPD3)

GGO:	101150410(THUMPD3)

PON:	100437974(THUMPD3)

PPYG:

129033837(THUMPD3)

NLE:	100592438(THUMPD3)

HMH:	116466699(THUMPD3)

SSYN:

129471083(THUMPD3)

MCC:	701564(THUMPD3)

MCF:	102142044(THUMPD3)

MTHB:

126947697

MNI:	105477652(THUMPD3)

CSAB:

103227966(THUMPD3)

CATY:

105585745(THUMPD3)

PANU:

101007262(THUMPD3)

TGE:	112618432(THUMPD3)

MLEU:

105552820(THUMPD3)

RRO:	104667471(THUMPD3)

RBB:	108530945(THUMPD3)

TFN:	117083201(THUMPD3)

PTEH:

111546959(THUMPD3)

CANG:

105519052(THUMPD3)

CJC:	100396111(THUMPD3)

SBQ:	101047985(THUMPD3)

CIMI:

108284694(THUMPD3)

ANAN:

105730176(THUMPD3)

CSYR:

103272159(THUMPD3)

MMUR:

105869028(THUMPD3)

LCAT:

123623338(THUMPD3)

ERUF:

138387024(THUMPD3)

PCOQ:

105812134(THUMPD3) 105814298

OGA:	100942577(THUMPD3)

MMU:	14911(Thumpd3)

MCAL:

110295745(Thumpd3)

MPAH:

110316310(Thumpd3)

RNO:	500288(Thumpd3)

MCOC:

116099382(Thumpd3)

ANU:	117714940(Thumpd3)

ASYL:

127668100 127679027(Thumpd3)

MUN:	110561364(Thumpd3)

CGE:	100753178(Thumpd3)

MAUA:

101832857(Thumpd3)

PROB:

127236144(Thumpd3)

PLEU:

114689591(Thumpd3)

PMAV:

102917708(Thumpd3)

MORG:

121437517(Thumpd3) 121442693

MFOT:

126505524

AAMP:

119806846(Thumpd3) 119807960

CNL:	130874897(Thumpd3)

NGI:	103751411(Thumpd3)

HGL:	101719405(Thumpd3)

CPOC:

100732259(Thumpd3)

CCAN:

109686988(Thumpd3)

DORD:

105981378(Thumpd3)

DSP:	122108091(Thumpd3) 122119422

DMER:

138824780 138840889

PLOP:

125358786(Thumpd3)

NCAR:

124970988

MMMA:

107144661 107150052(Thumpd3)

ITI:	101964588(Thumpd3)

OCU:

100345805

OPI:	101529109(THUMPD3)

OCZ:	121166073(THUMPD3)

TUP:	102489233(THUMPD3)

GVR:

103591129

CFA:	610222(THUMPD3)

CLUD:

112662263(THUMPD3) 125752940

VVP:	112933676(THUMPD3)

VLG:	121494756(THUMPD3)

NPO:	129521792(THUMPD3)

AML:	100480033(THUMPD3)

UMR:	103669581(THUMPD3)

UAH:	113257129(THUMPD3)

UAR:	123799179(THUMPD3)

ELK:

111143873

LLV:

125109207

MPUF:

101687833(THUMPD3)

MNP:	132006796 132011527(THUMPD3)

MLK:	131821446 131824186(THUMPD3)

NVS:	122905526 122909236(THUMPD3)

ORO:	101379080(THUMPD3)

EJU:	114207605(THUMPD3)

ZCA:	113917119(THUMPD3)

MLX:	118005363(THUMPD3) 118006228

MANO:

123841374(THUMPD3) 123842699

NSU:	110577989 110584899(THUMPD3)

LWW:	102751121(THUMPD3)

FCA:	101082638(THUMPD3)

PYU:	121040721 121041303(THUMPD3)

PCOO:

112858449(THUMPD3)

PBG:	122487471(THUMPD3)

PVIV:

125156756(THUMPD3)

LRUF:

124524004

LGF:	123605935(THUMPD3)

AJU:

106972351

PTG:	102951331(THUMPD3)

PPAD:

109254399(THUMPD3)

PUC:	125923163 125929599

PLEZ:

122203440(THUMPD3)

HHV:	120231281(THUMPD3)

CCRU:

144221138(THUMPD3)

BTA:	508940(THUMPD3)

BOM:	102271014(THUMPD3)

BIU:	109576160(THUMPD3)

BBUB:

102399837(THUMPD3)

BKE:	129635471(THUMPD3)

BBIS:

104990120(THUMPD3)

CHX:	102188540(THUMPD3)

OAS:	101106115(THUMPD3)

BTAX:

128043274(THUMPD3)

CSUM:

138087408(THUMPD3)

ODA:	120867688(THUMPD3)

CCAD:

122424621(THUMPD3)

MREE:

136166651(THUMPD3)

OVR:	110145754(THUMPD3)

MBEZ:

129541047 129548050(THUMPD3)

SSC:	100517782(THUMPD3)

CFR:	102518301(THUMPD3)

CBAI:

105067426(THUMPD3)

CDK:	105093144(THUMPD3)

VPC:	102530892(THUMPD3)

BACU:

103015824(THUMPD3)

BMUS:

118904343(THUMPD3)

LVE:	103083617(THUMPD3)

OOR:	101286809(THUMPD3)

LALB:

132526823(THUMPD3)

GMF:	115844118(THUMPD3)

DDP:	132432482(THUMPD3)

DLE:	111169946(THUMPD3)

PCAD:

102980923 102993828(THUMPD3)

PSIU:

116761958(THUMPD3)

PPHC:

136129797(THUMPD3)

NASI:

112396782(THUMPD3)

ECB:	100052534(THUMPD3)

EPZ:	103559007(THUMPD3)

EAI:	106823244 106841770(THUMPD3)

MYB:	102248241(THUMPD3)

MYD:	102755819(THUMPD3)

MMYO:

118668028(THUMPD3)

MLF:	102428230(THUMPD3)

MDT:	132215364(THUMPD3)

MYUM:

138992177(THUMPD3)

PKL:	118715184(THUMPD3)

EFUS:

103299457(THUMPD3) 114232174

MNA:	107534787(THUMPD3)

DRO:	112301189(THUMPD3)

SHON:

118980935 118993358(THUMPD3)

AJM:	119041405(THUMPD3)

PDIC:

114501546(THUMPD3)

PHAS:

123814571(THUMPD3)

MMF:	118633049(THUMPD3)

PPAM:

129088317(THUMPD3)

HAI:	109387275(THUMPD3)

RFQ:	117036752(THUMPD3)

PALE:

102880176(THUMPD3)

PGIG:

120621432(THUMPD3)

PVP:	105299062(THUMPD3)

RAY:	107505032(THUMPD3)

MJV:	108386347(THUMPD3)

TOD:	119255181(THUMPD3)

SARA:

101541020(THUMPD3)

SFUM:

130037594(THUMPD3)

SETR:

125998056(THUMPD3)

LAV:	100658670(THUMPD3)

TMU:

101346178

ETF:	101645194(THUMPD3)

DNM:	101438587(THUMPD3)

MDO:	100023704(THUMPD3)

GAS:	123236948(THUMPD3)

SHR:	100923322(THUMPD3)

AFZ:

127551652

PCW:	110199076(THUMPD3)

TVP:	118831397(THUMPD3)

PBRV:

138158083(THUMPD3)

MLAO:

141496279(THUMPD3)

OAA:	100075658(THUMPD3)

TACU:

119919590(THUMPD3)

GGA:	416116(THUMPD3)

PCOC:

116236602(THUMPD3)

MGP:	100544616(THUMPD3)

CJO:	107319925(THUMPD3)

TPAI:

128078414(THUMPD3)

LMUT:

125698723(THUMPD3)

NMEL:

110405038(THUMPD3)

APLA:

101796215(THUMPD3)

AACU:

137862223(THUMPD3)

OJA:	118173132(THUMPD3)

ACYG:

106036699(THUMPD3)

CATA:

118248072(THUMPD3)

AFUL:

116493137(THUMPD3)

TGU:	100218555(THUMPD3)

LSR:	110477117(THUMPD3)

VMC:	128814096(THUMPD3)

AIB:	137480898(THUMPD3)

SCAN:

103824137(THUMPD3)

PMOA:

120514114(THUMPD3)

OTC:	121347390(THUMPD3)

PRUF:

121352318(THUMPD3)

ATRC:

139595719(THUMPD3)

GFR:	102035754(THUMPD3)

FAB:	101814426(THUMPD3)

OMA:	130258104(THUMPD3)

PHI:	102106493(THUMPD3)

PMAJ:

107210514(THUMPD3)

CCAE:

111935275(THUMPD3)

CCW:	104683520(THUMPD3)

CBRC:

103616323(THUMPD3)

ACOE:

138117558(THUMPD3)

ETL:	114067682(THUMPD3)

ZAB:	102062959(THUMPD3)

ZLE:	135453326(THUMPD3)

ACHL:

103803332(THUMPD3)

SVG:	106850379(THUMPD3)

MMEA:

130585464(THUMPD3)

HRT:	120758433(THUMPD3)

SATI:

136366220(THUMPD3)

CFAI:

136296345(THUMPD3)

CCIC:

134048574(THUMPD3)

FPG:	101921750(THUMPD3)

FCH:	102057362(THUMPD3)

CCRI:

104162308(THUMPD3)

NNT:	104399604(THUMPD3)

SHAB:

115614318(THUMPD3)

ACUN:

113484886(THUMPD3)

ANOC:

141964307(THUMPD3)

SURA:

141947771(THUMPD3)

TALA:

104360999(THUMPD3)

ACHC:

115333328(THUMPD3)

HALD:

104311047(THUMPD3)

HLE:	104835247(THUMPD3)

AGEN:

126049961

HHAR:

128137304(THUMPD3)

BBUT:

142042768(THUMPD3)

GCL:

127021434

CSTI:

104550290(THUMPD3)

LDI:	104340466(THUMPD3)

MNB:	103769114(THUMPD3)

DPUB:

104303437(THUMPD3)

PPUS:

135182265(THUMPD3)

AVIT:

104267812(THUMPD3)

BRHI:

104502041(THUMPD3)

EGZ:	104121782(THUMPD3)

NNI:	104017013(THUMPD3)

PCRI:

104024876(THUMPD3)

PCAO:

104045756(THUMPD3)

PARX:

142058426(THUMPD3)

PADL:

103913609(THUMPD3)

AFOR:

103902856(THUMPD3)

FGA:	104070263(THUMPD3)

CBOR:

142086066(THUMPD3)

GSTE:

104251278(THUMPD3)

CBOY:

140658094(THUMPD3)

MAME:

142415763(THUMPD3)

CLV:	102086311(THUMPD3)

CNIC:

135993048(THUMPD3)

MUI:	104544091(THUMPD3)

PGUU:

104469137(THUMPD3)

PLET:

104614247(THUMPD3)

EHS:	104503715(THUMPD3)

CMAC:

104473691(THUMPD3)

CUCA:

104063632(THUMPD3)

TEO:	104381898(THUMPD3)

BREG:

104629732(THUMPD3)

GAME:

129211451(THUMPD3)

OHA:	104334375(THUMPD3)

ACAR:

104518333(THUMPD3)

CPEA:

104393855(THUMPD3)

CVF:	104284544(THUMPD3)

RTD:	128915570(THUMPD3)

CRID:

134521451(THUMPD3)

LMIC:

141749389(THUMPD3)

NARQ:

141467324(THUMPD3)

AAM:	106494626(THUMPD3)

AROW:

112970491(THUMPD3)

NPD:	112958720(THUMPD3)

TGT:	104571464(THUMPD3)

DNE:	112982934(THUMPD3)

SCAM:

104148134(THUMPD3)

ASN:	102378777(THUMPD3)

AMJ:	102577285(THUMPD3)

CPOO:

109311136(THUMPD3)

GGN:	109288934(THUMPD3)

PSS:	102444946(THUMPD3)

CIZ:	142019221(THUMPD3)

CMY:	102935149(THUMPD3)

CCAY:

125640134(THUMPD3)

LKP:	140914117(THUMPD3)

NDS:	141990416(THUMPD3)

DCC:	119859261(THUMPD3)

CPIC:

101937699(THUMPD3)

TST:	117880250(THUMPD3)

CABI:

116827056(THUMPD3)

MRV:	120409382(THUMPD3)

ACS:	100559541(thumpd3)

ASAO:

132769370(THUMPD3)

PVT:	110077868(THUMPD3)

PBI:	103056894(THUMPD3)

PMUR:

107298607(THUMPD3)

CTIG:

120319517(THUMPD3)

TSR:	106556308(THUMPD3)

PGUT:

117673910(THUMPD3)

PCAE:

139309502(THUMPD3)

APRI:

131192331(THUMPD3)

PTEX:

113451354(THUMPD3)

NSS:	113419344(THUMPD3)

VKO:	123034570(THUMPD3)

PMUA:

114591795(THUMPD3)

PRAF:

128408418(THUMPD3)

ZVI:	118080791(THUMPD3)

HCG:	128345679(THUMPD3)

GJA:	107122226(THUMPD3)

STOW:

125429336(THUMPD3)

EMC:	129326861(THUMPD3)

XLA:	108714635(thumpd3.L)

XTR:	447959(thumpd3)

NPR:	108786008(THUMPD3)

RTEM:

120945015(THUMPD3)

ACAT:

141102759(THUMPD3)

PADS:

140336987(THUMPD3)

BBUF:

120979033(THUMPD3)

BGAR:

122943546(THUMPD3)

DTC:	141088776(THUMPD3)

PWL:	138258973(THUMPD3)

MUO:	115472716(THUMPD3)

GSH:	117351367(THUMPD3)

DRE:	561938(thumpd3)

SRX:	107710156(thumpd3)

SANH:

107656116 107691495

SGH:	107562894 107586349

CCAR:

109059747 109105756(thumpd3)

CAUA:

113097637(thumpd3)

CGIB:

127959803

PTET:

122346376(thumpd3)

LROH:

127167431(thumpd3)

GRF:	141347212(thumpd3)

OMC:	131541839(thumpd3)

PPRM:

120466945(thumpd3)

MAMB:

125278108(thumpd3)

CIDE:

127514138

CERY:

137011177(thumpd3)

MASI:

127446053

TROS:

130557191(thumpd3)

TDW:	130425260(thumpd3)

IPU:

108271894

IFU:	128615065(thumpd3)

PHYP:

113535712(thumpd3)

SMEO:

124385920(thumpd3)

TFD:	113643076(thumpd3)

TVC:	132844500(thumpd3)

CGAR:

128527272(thumpd3)

NGRA:

132885165(thumpd3)

TRN:	134317315(thumpd3)

AMEX:

103042194(thumpd3)

CMAO:

118808371(thumpd3)

EEE:	113569606(thumpd3)

CHAR:

105905149(thumpd3)

SPIL:

134091997(thumpd3)

ASAD:

121707586(thumpd3)

TRU:	101079317(thumpd3)

TFS:	130524451(thumpd3)

TNG:	GSTEN00027309G001

LCO:	104928130(thumpd3)

NCC:	104950924(thumpd3)

TBEN:

117489459(thumpd3)

CGOB:

115008601(thumpd3)

PGEO:

117446644(thumpd3)

GACU:

117551181(thumpd3)

EMAC:

134883011(thumpd3)

ELY:	117256269(thumpd3)

EFO:	125887338(thumpd3)

PLEP:

121956835(thumpd3)

SLUC:

116041709(thumpd3)

ECRA:

117943856(thumpd3)

ESP:	116688088(thumpd3)

PFLV:

114554951(thumpd3)

GAT:	120835582(thumpd3)

PPUG:

119194105(thumpd3)

AFB:	129105986(thumpd3)

CLUM:

117731240(thumpd3)

PSWI:

130208805(thumpd3)

CANA:

137795862(thumpd3)

CVE:	137873475(thumpd3)

MSAM:

119886339(thumpd3)

SCHU:

122862973(thumpd3)

EARM:

139283056(thumpd3)

CUD:	121507098(thumpd3)

SPUL:

138606068(thumpd3)

LMIX:

132977387(thumpd3)

HTC:	141797027(thumpd3)

ALAT:

119020587(thumpd3)

ASTR:

137594834(thumpd3)

PKLU:

139207649(thumpd3)

MZE:	101482384(thumpd3)

ONL:	100693768(thumpd3)

OAU:	116333877(thumpd3)

OLA:	101171156(thumpd3)

OML:	112144759(thumpd3)

CSAI:

133448508(thumpd3)

XMA:	102224480(thumpd3)

XCO:	114135635(thumpd3)

XHE:	116710527(thumpd3)

PRET:

103465212(thumpd3)

PFOR:

103150693(thumpd3)

PLAI:

106950351(thumpd3)

PMEI:

106931061(thumpd3)

GAF:	122834641(thumpd3)

PPRL:

129355731(thumpd3)

CVG:	107093344(thumpd3)

CTUL:

119780071(thumpd3)

GMU:	124857491(thumpd3)

NFU:	107385743(thumpd3)

KMR:	108235778(thumpd3)

ALIM:

106517978(thumpd3)

NWH:

119411963

AOCE:

111575519(thumpd3)

EJA:	138200883(thumpd3)

BFRE:

138636918(thumpd3)

MCEP:

125006983(thumpd3)

CSEM:

103385897(thumpd3)

POV:	109628868(thumpd3)

SSEN:

122768405(thumpd3)

SSOE:

131461352(thumpd3)

HHIP:

117761809(thumpd3)

HSP:	118104430(thumpd3)

PPLT:

128460638(thumpd3)

SMAU:

118309659(thumpd3)

LCF:

108886453

SDU:	111222101(thumpd3)

SLAL:

111660835(thumpd3)

XGL:	120807603(thumpd3)

HCQ:	109522599(thumpd3)

SSCV:

125976859(thumpd3)

SBIA:

133507611(thumpd3)

PEE:	133408883(thumpd3)

PTAO:

133483671(thumpd3)

BPEC:

110168655(thumpd3)

ENY:	140365673(thumpd3)

MALB:

109964507(thumpd3)

BSPL:

114856104(thumpd3)

SJO:	128355847(thumpd3)

SSCO:

133977775(thumpd3)

TTY:	137181584(thumpd3)

GMH:	115557035(thumpd3)

SASA:

100196621(thumpd3)

STRU:

115207895(thumpd3)

OTW:	112217032(thumpd3)

OMY:	110494261(thumpd3)

OGO:	124003516(thumpd3)

ONE:	115143124(thumpd3)

OKI:	109895391(thumpd3)

OKE:	118388623(thumpd3)

OMM:	135539928(thumpd3)

OCLA:

139371039

SALP:

111966343(thumpd3)

SNH:	120025383(thumpd3)

SFON:

129847198(thumpd3)

CCLU:

121575211(thumpd3)

ELS:	105017024(thumpd3)

OEP:	134028938(thumpd3)

SFM:	108923411(thumpd3)

PKI:	111833091(thumpd3)

AANG:

118211428(thumpd3)

AROT:

135237800(thumpd3)

CCOG:

133110092(thumpd3)

LOC:	102683512(thumpd3)

PSPA:

121329064(thumpd3)

ARUT:

117413795

PSEX:

120541378(thumpd3)

LCM:	102363619(THUMPD3)

CMK:	103176716(thumpd3)

RTP:	109925905(thumpd3)

CPLA:

122559153(thumpd3)

CPUN:

140483897(thumpd3)

HOC:	132822400(thumpd3)

SCAU:

119973163(thumpd3)

LERI:

129704576(thumpd3)

HAKA:

140741932(thumpd3)

PMRN:

116949378(THUMPD3)

LRJ:	133342614(THUMPD3)

BFO:

BBEL:

CIN:

SCLV:

CLEP:

SPU:

LPIC:

LVG:	121411796 121411798

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

TLN:

TAME:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

MDL:

CGLO:

CTYP:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

CCRN:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

LDA:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

PVM:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

SPRM:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

OOT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

DALB:

RSAN:

RMP:

VDE:

VJA:

GOE:

DPTE:

DFR:

CSCU:

CVS:

LPOL:

PMEO:

CEL:	CELE_M04B2.2(thum-3)

CBR:

CBG_06137

CRQ:	GCK72_014159

HRO:	HELRODRAFT_62761

LGI:	LOTGIDRAFT_105490

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_25997

CCLM:

134197819

ACAN:

ACA1_285490

» show all

Reference

PMID:34669960

Authors

Yang WQ, Xiong QP, Ge JY, Li H, Zhu WY, Nie Y, Lin X, Lv D, Li J, Lin H, Liu RJ

Title

THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates.

Journal

Nucleic Acids Res 49:11900-11919 (2021)
DOI:10.1093/nar/gkab927

Sequence

[hsa:25917]

LinkDB

DBGET integrated database retrieval system