KEGG ORTHOLOGY: K28404

ORTHOLOGY: K28404

Entry

K28404                      KO

Symbol

CIROZ

Name

ciliated left-right organizer protein containing ZP-N domains

Disease

H00632

Heterotaxy

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K28404  CIROZ; ciliated left-right organizer protein containing ZP-N domains
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Other motile cilia associated proteins
   K28404  CIROZ; ciliated left-right organizer protein containing ZP-N domains

Genes

HSA:	148345(CIROZ)

PTR:	469794(C1H1orf127)

PPS:	100983111(C1H1orf127)

GGO:	101125973(C1H1orf127)

PON:	100460093(C1H1orf127)

PPYG:

129008040(C1H1orf127)

NLE:	100592921(C24H1orf127)

HMH:	116813896(CUNH1orf127)

SSYN:

129472205(C22H1orf127)

MCC:	713731(C1H1orf127)

MCF:	102132976(CIROZ)

MTHB:

126953768(C1H1orf127)

MNI:	105473141(CUNH1orf127)

CSAB:

103225620(C20H1orf127)

CATY:

105580877

PANU:

101011125(C1H1orf127)

TGE:	112604938(C1H1orf127)

MLEU:

105551395

RRO:	104654368(C12H1orf127)

RBB:	108539332(CUNH1orf127)

TFN:	117093331(CUNH1orf127)

PTEH:

111526323(C1H1orf127) 113220560

CANG:

105507349

CJC:	100404658(C7H1orf127)

SBQ:

101048563

CIMI:

108286255(CUNH1orf127)

ANAN:

105731812(CUNH1orf127)

CSYR:

103252232(CUNH1orf127)

MMUR:

105886049(C2H1orf127)

LCAT:

123634894(C3H1orf127)

ERUF:

138390233(C8H1orf127)

PCOQ:

105824885

OGA:	100955660(CUNH1orf127)

MMU:	230909(Gm572)

MCAL:

110293770(C4H1orf127)

MPAH:

110323949(C6H1orf127)

RNO:	691354(C5h1orf127)

MCOC:

116095679 116097022(CUNH1orf127)

ANU:	117709365(Ciroz)

ASYL:

127680192(C3H1orf127)

MUN:	110548147 132652938

CGE:	100770375(CUNH1orf127)

MAUA:

101832046(CUNH1orf127)

PROB:

127213467(CUNH1orf127)

PLEU:

114709667(C2H1orf127)

MORG:

121441753 121448420

MFOT:

126508130(CUNH1orf127)

AAMP:

119817162(C6H1orf127)

NGI:	103733201(CUNH1orf127)

HGL:

101706451

CPOC:

100726018(CUNH1orf127)

CCAN:

109703348

DORD:

105997384

DSP:	122121424(CUNH1orf127)

DMER:

138838445(CUNH1orf127)

PLOP:

125355616(C7H1orf127)

NCAR:

124982283

MMMA:

107155414(CUNH1orf127)

ITI:	101975445(CUNH1orf127)

OCU:	108176210(CUNH1orf127)

OPI:	101526109(C13H1orf127)

OCZ:	121161290(CUNH1orf127)

TUP:

102476428

GVR:

103599998

AML:	105239088(C11H1orf127)

UMR:	103666867(CUNH1orf127)

MPUF:

106007421

MLK:	131809915(C10H1orf127)

NVS:	122899068(C2H1orf127)

ORO:

101371924

EJU:	114213244(CUNH1orf127)

ZCA:	113927040(C4H1orf127)

MLX:	118019646(CUNH1orf127)

MANO:

135364045(CUNH1orf127)

LWW:	115941641(CUNH1orf127)

PYU:	121027829(CUNH1orf127)

PBG:	122482050(CC1H1orf127)

LRUF:

124514416

LGF:	123599785(CC1H1orf127)

PTG:

107179267

PPAD:

109273872(CUNH1orf127)

HHV:	120233617(CUNH1orf127)

CHX:	108637737(C16H1orf127)

ODA:	120879839(CUNH1orf127)

CFR:	102513239(C13H1orf127)

CBAI:

105071160

CDK:	105107095(C13H1orf127)

VPC:	102532959(C13H1orf127)

BACU:

103004556

BMUS:

118880485(C1H1orf127)

LVE:

103083342

OOR:	101284409(C1H1orf127)

DLE:	111187073(CUNH1orf127)

PCAD:

102973548(C3H1orf127)

ECB:	106782824(C2H1orf127)

EPZ:	139081864(C2H1orf127)

EAI:	106836703(C5H1orf127)

MYB:

102255000

MMYO:

118677727(CUNH1orf127)

MLF:	102434597(CUNH1orf127)

MDT:	132229801(C3H1orf127)

MYUM:

139001540(CUNH1orf127)

DRO:	112299655(CUNH1orf127)

SHON:

118986280(CUNH1orf127)

AJM:	119064104(CUNH1orf127)

PHAS:

123831670(CUNH1orf127)

MMF:	118626835(CUNH1orf127)

HAI:	109381219(CUNH1orf127)

RFQ:	117026744(C9H1orf127)

PALE:

112481763(CUNH1orf127)

LAV:	100662578(CUNH1orf127)

TMU:

101348636

ETF:	123522686(CUNH1orf127)

DNM:	101438761(CUNH1orf127)

MDO:	100619801(C4H1orf127)

SHR:	100932519(C3H1orf127)

PCW:	110203126(CUNH1orf127)

TVP:	118836298(C2H1orf127)

PBRV:

138154324(CUNH1orf127)

OAA:	100079569(C5H1orf127)

XLA:	108696361(c1orf127.L)

XTR:	100490273(c1orf127)

RTEM:

120916119(C10H1orf127)

DRE:	101883649(ciroz)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

128011553(cb23h1orf127)

PTET:

122328730(c23h1orf127)

LROH:

127155308(c23h1orf127)

OMC:	131531749(c23h1orf127)

PPRM:

120463713(cunh1orf127)

RKG:	130074114(cunh1orf127)

MAMB:

125260088(lg24h1orf127)

CIDE:

127504821(c22h1orf127)

CERY:

137009664(c20h1orf127)

MASI:

127420137(c29h1orf127)

TROS:

130545394(lg21h1orf127)

TDW:	130409636(c20h1orf127)

MANU:

129430712(ciroz)

PDAB:

135775411(ciroz)

IPU:	108276096(c15h1orf127)

IFU:	128619411(c15h1orf127)

PHYP:

113530432(cunh1orf127)

TFD:	113658157(c23h1orf127)

TVC:	132861801(c19h1orf127)

TRN:	134333847(c19h1orf127)

AMEX:

103044414(c13h1orf127)

CMAO:

118822478(cunh1orf127)

EEE:	113581296(cunh1orf127)

CHAR:

122130837(cunh1orf127)

SPIL:

134088117(c7h1orf127)

TRU:	105416258(ciroz)

TFS:	130530100(c8h1orf127)

TNG:	GSTEN00028244G001

NCC:

104954118

TBEN:

117494289(cunh1orf127)

CGOB:

115010855(c7h1orf127)

PGEO:

117448897(ciroz)

GACU:

117541800(cunh1orf127)

EMAC:

134868590(c1h1orf127)

EFO:	125891632(lg7h1orf127)

SLUC:

116040615(c12h1orf127)

ECRA:

117948262(c7h1orf127)

ESP:	116674437 116692917(c7h1orf127)

PFLV:

114559215(c7h1orf127)

GAT:	120829813(c12h1orf127)

PPUG:

119222740(c1h1orf127)

AFB:	129099425(c12h1orf127)

PSWI:

130199968(c9h1orf127)

CANA:

137800866(cunh1orf127)

MSAM:

119906081

SCHU:

122883431(lg10h1orf127)

ALAT:

119023128(c7h1orf127)

LCO:	109137084(cxvh1orf127)

MZE:	101464992(ciroz)

ONL:	102076052(lg20h1orf127)

OAU:	120435163(c20h1orf127)

MCEP:

125019188(c1h1orf127)

AOCE:

111573231(c8h1orf127)

EJA:	138192815(cunh1orf127)

BFRE:

138615402(cunh1orf127)

LCF:	108876395(lg6h1orf127)

POV:	109630689(cunh1orf127)

SSEN:

122776674(lg11h1orf127)

SSOE:

131468393(c11h1orf127)

HHIP:

117764963(c7h1orf127)

PPLT:

128442020(c6h1orf127)

SMAU:

118316349(c3h1orf127)

SLAL:

111670822(cunh1orf127)

XGL:	120804144(c18h1orf127)

ENY:	140362496(ciroz)

MALB:

109971632(cunh1orf127)

BSPL:

114858686(c7h1orf127)

SASA:

106572053(cssa15h1orf127)

STRU:

115166363(ciroz) 115166422

CCLU:

121537503(c24h1orf127)

OEP:	134019396(c4h1orf127)

SFM:	114909264(c2h1orf127)

PKI:	111834416(cunh1orf127)

AANG:

118207969(c11h1orf127)

AROT:

135235051

CCOG:

133138289(c10h1orf127)

LOC:	107075584(clg25h1orf127)

PSPA:

121328506(c16h1orf127)

ARUT:

117425807 117432227

» show all

Reference

PMID:39753129

Authors

Szenker-Ravi E, Ott T, Yusof A, Chopra M, Khatoo M, Pak B, Xuan Goh W, Beckers A, Brady AF, Ewans LJ, Djaziri N, Almontashiri NAM, Alghamdi MA, Alharby E, Dasouki M, Romo L, Tan WH, Maddirevula S, Alkuraya FS, Giordano JL, Alkelai A, Wapner RJ, Stals K, Alfadhel M, Alswaid AF, Bogusch S, Schafer-Kosulya A, Vogel S, Vick P, Schweickert A, Wakeling M, Moreau de Bellaing A, Alshamsi AM, Sanlaville D, Mbarek H, Saad C, Ellard S, Eisenhaber F, Tripolszki K, Beetz C, Bauer P, Gossler A, Eisenhaber B, Blum M, Bouvagnet P, Bertoli-Avella A, Amiel J, Gordon CT, Reversade B

Title

CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans.

Journal

Am J Hum Genet S0002-9297(24)00448-8 (2024)
DOI:10.1016/j.ajhg.2024.12.006

Sequence

[hsa:148345]

LinkDB

DBGET integrated database retrieval system