KEGG   MODULE: M00063
Entry
M00063            Pathway   Module                                 

Name
CMP-KDO biosynthesis
Definition
K06041 K01627 K03270 K00979
Diagram
M00063

Orthology
K06041  
arabinose-5-phosphate isomerase [EC:5.3.1.13] [RN:R01530]
K01627  
2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] [RN:R03254]
K03270  
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] [RN:R03350]
K00979  
3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] [RN:R03351]
Class
Pathway modules; Glycan metabolism; Lipopolysaccharide metabolism
Pathway
map00540  Lipopolysaccharide biosynthesis
map01250  Biosynthesis of nucleotide sugars
map01100  Metabolic pathways
Reaction
Compound
C00199  D-Ribulose 5-phosphate
C01112  D-Arabinose 5-phosphate
C04478  3-Deoxy-D-manno-octulosonate 8-phosphate
C01187  3-Deoxy-D-manno-octulosonate
C04121  CMP-3-deoxy-D-manno-octulosonate
RModule
RM042  Nucleotide sugar biosynthesis, type 4
Reference
  Authors
Lodowska J, Wolny D, Weglarz L
  Title
The sugar 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) as a characteristic component of bacterial endotoxin -- a review of its biosynthesis, function, and placement in the lipopolysaccharide core.
  Journal
Can J Microbiol 59:645-55 (2013)
DOI:10.1139/cjm-2013-0490
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