KEGG   MODULE: M00119
Entry
M00119            Pathway   Module                                 
Name
Pantothenate biosynthesis, valine/L-aspartate => pantothenate
Definition
K00826 K00606 K00077
K01579
(K01918,K13799)
Diagram
M00119

Orthology
K00826  
branched-chain amino acid aminotransferase [EC:2.6.1.42] [RN:R01214]
K00606  
3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] [RN:R01226]
K00077  
2-dehydropantoate 2-reductase [EC:1.1.1.169] [RN:R02472]
K01579  
aspartate 1-decarboxylase [EC:4.1.1.11] [RN:R00489]
K01918,K13799  
pantoate--beta-alanine ligase [EC:6.3.2.1] [RN:R02473]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00770  Pantothenate and CoA biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R01214  
R01226  
R02472  
R00489  
R02473  
Compound
C00183  L-Valine
C00141  3-Methyl-2-oxobutanoic acid
C00966  2-Dehydropantoate
C00522  (R)-Pantoate
C00049  L-Aspartate
C00099  beta-Alanine
C00864  Pantothenate
Reference
PMID:11153265
  Authors
Begley TP, Kinsland C, Strauss E
  Title
The biosynthesis of coenzyme A in bacteria.
  Journal
Vitam Horm 61:157-71 (2001)
DOI:10.1016/s0083-6729(01)61005-7
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