KEGG   MODULE: M00632
Entry
M00632            Pathway   Module                                 
Name
Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P
Definition
K01785 K00849 K00965 K01784
Diagram
M00632

Orthology
K01785  
aldose 1-epimerase [EC:5.1.3.3] [RN:R10619]
K00849  
galactokinase [EC:2.7.1.6] [RN:R01092]
K00965  
UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12] [RN:R00955]
K01784  
UDP-glucose 4-epimerase [EC:5.1.3.2] [RN:R00291]
Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00052  Galactose metabolism
map01100  Metabolic pathways
Reaction
Compound
C00124  D-Galactose
C00984  alpha-D-Galactose
C00446  alpha-D-Galactose 1-phosphate
C00029  UDP-glucose
C00052  UDP-alpha-D-galactose
C00103  D-Glucose 1-phosphate
Reference
PMID:8647345
  Authors
Frey PA
  Title
The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose.
  Journal
FASEB J 10:461-70 (1996)
DOI:10.1096/fasebj.10.4.8647345
Reference
  Authors
Thoden JB, Timson DJ, Reece RJ, Holden HM
  Title
Molecular structure of human galactose mutarotase.
  Journal
J Biol Chem 279:23431-7 (2004)
DOI:10.1074/jbc.M402347200
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