KEGG   MODULE: M00649
Entry
M00649            Signature Module                                 
Name
Multidrug resistance, efflux pump AdeABC
Definition
K18143 K18144 K18145+K18146-K18147
Diagram
M00649  Multidrug resistance, efflux pump AdeABC
M00649

Class
Signature modules; Gene set; Drug resistance
Pathway
map01501  beta-Lactam resistance
Orthology
K18143  
adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]
K18144  
adeR; two-component system, OmpR family, response regulator AdeR
K18145  
adeA; membrane fusion protein
K18146  
adeB; multidrug efflux pump
K18147  
adeC; outer membrane protein
Complete
koc  Klebsiella oxytoca CAV1374
yca  Yersinia canariae
nig  Nissabacter sp. SGAir0207
sera  Prodigiosinella confusarubida ATCC 39006
serq  Prodigiosinella confusarubida ATCC 39006
prod  Prodigiosinella aquatilis
pcc  Pectobacterium carotovorum subsp. carotovorum PCC21
ppuj  Pectobacterium punjabense
ddd  Dickeya dadantii 3937
dze  Dickeya chrysanthemi
ddc  Dickeya parazeae
dzc  Dickeya zeae
dso  Dickeya solani IPO 2222
daq  Dickeya aquatica
dic  Dickeya poaceiphila
dlc  Dickeya lacustris
dad  Dickeya ananatis
erp  Erwinia rhapontici
pdis  Pantoea soli
palf  Pantoea alfalfae
xsa  Xanthomonas sacchari
xas  Xanthomonas sp. SS
xha  Xanthomonas hawaiiensis
xry  Xanthomonas rydalmerensis
xso  Xanthomonas sontii
xin  Xanthomonas indica
xmd  Xanthomonas medicagonis
sml  Stenotrophomonas maltophilia K279a
smt  Stenotrophomonas maltophilia R551-3
buj  Stenotrophomonas maltophilia JV3
smz  Stenotrophomonas maltophilia D457
sfoe  Stenotrophomonas forensis
sten  Stenotrophomonas sp. WZN-1
stem  Stenotrophomonas sp. MYb57
stes  Stenotrophomonas sp. ASS1
sinc  Stenotrophomonas indicatrix
spaq  Stenotrophomonas pavanii
sgen  Stenotrophomonas geniculata
stej  Stenotrophomonas sp. SBJS02
steo  Stenotrophomonas sp. Pemsol
stez  Stenotrophomonas sp. P2112
slab  Stenotrophomonas lactitubi
lanh  Luteibacter anthropi
vga  Vibrio gazogenes
vsr  Vibrio spartinae
vpl  Vibrio paracholerae
vru  Vibrio ruber
poj  Metapseudomonas otitidis
poi  Pseudomonas orientalis
pkc  Pseudomonas knackmussii
pmk  Ectopseudomonas mendocina NK-01
emo  Entomomonas moraniae
acb  Acinetobacter baumannii ATCC 17978
aby  Acinetobacter baumannii AYE
abc  Acinetobacter baumannii ACICU
abn  Acinetobacter baumannii AB0057
abb  Acinetobacter baumannii AB307-0294
abx  Acinetobacter baumannii 1656-2
abz  Acinetobacter baumannii MDR-ZJ06
abr  Acinetobacter baumannii MDR-TJ
abd  Acinetobacter baumannii TCDC-AB0715
abh  Acinetobacter baumannii TYTH-1
abad  Acinetobacter baumannii D1279779
abj  Acinetobacter baumannii BJAB07104
abab  Acinetobacter baumannii BJAB0715
abaj  Acinetobacter baumannii BJAB0868
abaz  Acinetobacter baumannii ZW85-1
abk  Acinetobacter baumannii AbH12O-A2
abau  Acinetobacter baumannii AB030
abw  Acinetobacter baumannii AC29
aban  Acinetobacter baumannii AB5075-UW
acc  Acinetobacter pittii
alc  Acinetobacter lactucae
acal  Acinetobacter calcoaceticus
asei  Acinetobacter seifertii
acd  Acinetobacter oleivorans
ajo  Acinetobacter johnsonii
asol  Acinetobacter soli
adv  Acinetobacter defluvii
agu  Acinetobacter guillouiae
ads  Acinetobacter dispersus
aber  Acinetobacter bereziniae
achi  Acinetobacter chinensis
atg  Acinetobacter towneri
abou  Acinetobacter bouvetii
agyl  Acinetobacter gyllenbergii
apot  Acinetobacter portensis
aprl  Acinetobacter proteolyticus
acoi  Acinetobacter colistiniresistens
aviv  Acinetobacter vivianii
acie  Acinetobacter sp. BHS4
asue  Acinetobacter suaedae
acot  Acinetobacter corruptisaponis
acic  Acinetobacter sp. Ac-14
aciz  Acinetobacter sp. Tol 5
shp  Shewanella putrefaciens 200
shw  Shewanella sp. W3-18-1
sxm  Shewanella xiamenensis
shej  Shewanella sp. JNE2
sdeo  Shewanella decolorationis
sog  Shewanella oncorhynchi
shel  Shewanella sp. LZH-2
psmb  Pseudoalteromonas sp. MT33b
alr  Alteromonas sp. RKMC-009
mtha  Methylophaga thalassica
alv  Allochromatium vinosum
tmb  Thioflavicoccus mobilis
rhei  Rheinheimera sp. F8
hak  Halomonas sp. KO116
ham  Halomonas sp. R57-5
hpro  Halomonas profundus
half  Halomonas alkaliantarctica
haah  Halomonas sp. A3H3
habd  Halomonas sp. BDJS001
hany  Halomonas sp. NyZ770
htt  Vreelandella titanicae
vre  Vreelandella sp. F11
vrs  Vreelandella sp. SM1641
adi  Alloalcanivorax dieselolei
mmw  Marinomonas sp. MWYL1
nik  Nitrincola iocasae
aha  Aeromonas hydrophila subsp. hydrophila ATCC 7966
ahd  Aeromonas hydrophila YL17
ahi  Aeromonas hydrophila AH10
aaj  Aeromonas hydrophila MX16A
avr  Aeromonas veronii B565
avo  Aeromonas veronii TH0426
adh  Aeromonas dhakensis
aea  Aeromonas sp. ASNIH3
arv  Aeromonas rivipollensis
aes  Aeromonas sp. ASNIH5
asim  Aeromonas simiae
chro  Chromobacterium sp. ATCC 53434
amah  Aquitalea magnusonii
rso  Ralstonia pseudosolanacearum GMI1000
rse  Ralstonia pseudosolanacearum FQY_4
rpu  Ralstonia pseudosolanacearum RS 476
rnc  Ralstonia nicotianae
rsn  Ralstonia solanacearum Po82
rsy  Ralstonia solanacearum UY031
bur  Burkholderia lata
bcm  Burkholderia orbicola
bch  Burkholderia cenocepacia HI2424
bcj  Burkholderia cenocepacia J2315
bcen  Burkholderia cenocepacia DDS 22E-1
bceo  Burkholderia cenocepacia H111
bmj  Burkholderia multivorans ATCC 17616 (Tohoku)
bmu  Burkholderia multivorans ATCC 17616 (JGI)
bct  Burkholderia cepacia GG4
bced  Burkholderia cepacia DDS 7H-2
bcep  Burkholderia cepacia ATCC 25416
bpyr  Burkholderia pyrrocinia
bcon  Burkholderia contaminans
bub  Burkholderia ubonensis
bsem  Burkholderia seminalis
bpsl  Burkholderia pseudomultivorans
bmec  Burkholderia metallica
bstg  Burkholderia stagnalis
bstl  Burkholderia stabilis
bari  Burkholderia arboris
bser  Burkholderia semiarida
bgu  Burkholderia glumae LMG 2196 = ATCC 33617
burm  Burkholderia sp. MS389
burf  Burkholderia sp. FERM BP-3421
cabk  Caballeronia sp. NK8
asah  Acidovorax sacchari
aav  Paracidovorax citrulli
aaa  Paracidovorax avenae
rge  Rubrivivax gelatinosus
rbn  Rubrivivax benzoatilyticus
rdp  Roseateles depolymerans
snn  Sphaerotilus sulfidivorans
ater  Aquincola tertiaricarbonis
jaz  Janthinobacterium sp. 1_2014MBL_MicDiv
jal  Janthinobacterium sp. LM6
jsv  Janthinobacterium svalbardensis
jas  Janthinobacterium tructae
jlv  Janthinobacterium lividum
jah  Janthinobacterium sp. HH102
jri  Janthinobacterium rivuli
jae  Janthinobacterium aestuarii
dsu  Azospira oryzae
agr  Agrobacterium tumefaciens H13-3
arai  Agrobacterium radiobacter
asal  Agrobacterium salinitolerans
rhiw  Rhizobium sp. WYJ-E13
rpc  Rhodopseudomonas palustris BisB18
rhol  Rhodopseudomonas sp. BAL398
maad  Martelella sp. AD-3
mmed  Martelella mediterranea
aua  Aureimonas sp. AU20
pphr  Pannonibacter phragmitetus
siw  Stappia indica
cfh  Caulobacter flavus
cauf  Caulobacter sp. FWC26
bnd  Brevundimonas nasdae
bfq  Brevundimonas fontaquae
ypac  Alloyangia pacifica
cazt  Cereibacter azotoformans
rsu  Rhodovulum sulfidophilum
rhm  Rhodovulum sp. MB263
rhov  Rhodovulum sp. HP10
rcp  Rhodobacter capsulatus
nhum  Novosphingobium humi
span  Sphingomonas panacis
spau  Sphingomonas paucimobilis
swi  Rhizorhabdus wittichii RW1
sphd  Rhizorhabdus wittichii DC-6
ssy  Sphingobium sp. SYK-6
sclo  Sphingobium cloacae
sphs  Sphingosinicella sp. BN140058
altn  Altererythrobacter sp. N1
caen  Caenibius sp. WL
azl  Azospirillum sp. B510
abs  Azospirillum baldaniorum Sp245
ahu  Azospirillum humicireducens
adj  Azospirillum doebereinerae
smuc  Skermanella mucosa
rce  Rhodospirillum centenum
 » show all
Reference
PMID:23217848
  Authors
Lopes BS, Amyes SG
  Title
Insertion sequence disruption of adeR and ciprofloxacin resistance caused by efflux pumps and gyrA and parC mutations in Acinetobacter baumannii.
  Journal
Int J Antimicrob Agents 41:117-21 (2013)
DOI:10.1016/j.ijantimicag.2012.08.012
Reference
PMID:19056528
  Authors
Wieczorek P, Sacha P, Hauschild T, Zorawski M, Krawczyk M, Tryniszewska E
  Title
Multidrug resistant Acinetobacter baumannii--the role of AdeABC (RND family) efflux pump in resistance to antibiotics.
  Journal
Folia Histochem Cytobiol 46:257-67 (2008)
DOI:10.2478/v10042-008-0056-x
Reference
PMID:15328088
  Authors
Marchand I, Damier-Piolle L, Courvalin P, Lambert T
  Title
Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system.
  Journal
Antimicrob Agents Chemother 48:3298-304 (2004)
DOI:10.1128/AAC.48.9.3298-3304.2004
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