KEGG   MODULE: M00652
Entry
M00652            Signature Module                                 
Name
Vancomycin resistance, D-Ala-D-Ser type
Definition
K18350 K18349 K18348 K18856 K18866
Diagram
M00652

Orthology
K18350  
vanSE; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
K18349  
vanRE; two-component system, OmpR family, response regulator VanR
K18348  
vanT; serine/alanine racemase [EC:5.1.1.18 5.1.1.1]
K18856  
vanC; D-alanine---D-serine ligase [EC:6.3.2.35]
K18866  
vanXY; D-alanyl-D-alanine dipeptidase/carboxypeptidase [EC:3.4.13.22 3.4.16.4]
Class
Signature modules; Gene set; Drug resistance
Pathway
map01502  Vancomycin resistance
map02020  Two-component system
Reference
PMID:10878136
  Authors
Arias CA, Weisner J, Blackburn JM, Reynolds PE
  Title
Serine and alanine racemase activities of VanT: a protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174.
  Journal
Microbiology 146 ( Pt 7):1727-34 (2000)
DOI:10.1099/00221287-146-7-1727
Reference
PMID:22913355
  Authors
Chancey ST, Zahner D, Stephens DS
  Title
Acquired inducible antimicrobial resistance in Gram-positive bacteria.
  Journal
Future Microbiol 7:959-78 (2012)
DOI:10.2217/fmb.12.63
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