KEGG   MODULE: M00696
Entry
M00696            Signature Module                                 
Name
Multidrug resistance, efflux pump AcrEF-TolC
Definition
K18140 K18141+K18142+K12340
Diagram
M00696  Multidrug resistance, efflux pump AcrEF-TolC
M00696

Class
Signature modules; Gene set; Drug resistance
Orthology
K18140  
envR, acrS; TetR/AcrR family transcriptional regulator, acrEF/envCD operon repressor [COG:COG1309]
K18141  
acrE; membrane fusion protein [COG:COG0845] [TC:2.A.6.2]
K18142  
acrF; multidrug efflux pump [COG:COG0841] [TC:2.A.6.2]
K12340  
tolC; outer membrane channel protein [COG:COG1538] [TC:1.B.17 2.A.6.2]
Complete
eco  Escherichia coli K-12 MG1655
ecj  Escherichia coli K-12 W3110
ecd  Escherichia coli K-12 DH10B
ebw  Escherichia coli K-12 BW2952
ecok  Escherichia coli K-12 MDS42
ecoc  Escherichia coli K-12 C3026
ece  Escherichia coli O157:H7 EDL933 (EHEC)
elx  Escherichia coli O157:H7 Xuzhou21 (EHEC)
eoi  Escherichia coli O111:H- 11128 (EHEC)
eoj  Escherichia coli O26:H11 11368 (EHEC)
eoh  Escherichia coli O103:H2 12009 (EHEC)
ecoo  Escherichia coli O145:H28 RM13514 (EHEC)
ecoh  Escherichia coli O145:H28 RM13516 (EHEC)
esl  Escherichia coli O104:H4 2011C-3493 (EAEC)
eso  Escherichia coli O104:H4 2009EL-2071 (EAEC)
esm  Escherichia coli O104:H4 2009EL-2050 (EAEC)
eck  Escherichia coli 55989 (EAEC)
ecg  Escherichia coli O127:H6 E2348/69 (EPEC)
eok  Escherichia coli O55:H7 CB9615 (EPEC)
elr  Escherichia coli O55:H7 RM12579 (EPEC)
elh  Escherichia coli O78:H11:K80 H10407 (ETEC)
ecw  Escherichia coli O139:H28 E24377A (ETEC)
eun  Escherichia coli UMNK88 (ETEC, porcine)
ecp  Escherichia coli O6:K15:H31 536 (UPEC)
ena  Escherichia coli NA114 (UPEC)
ecos  Escherichia coli O25b:K100:H4-ST131 EC958 (UPEC)
ecv  Escherichia coli APEC O1 (APEC)
ecoa  Escherichia coli APEC O78 (APEC)
ecx  Escherichia coli O9 HS (commensal)
ecy  Escherichia coli O152:H28 SE11 (commensal)
ecr  Escherichia coli O8 IAI1 (commensal)
ecq  Escherichia coli O81 ED1a (commensal)
eum  Escherichia coli O17:K52:H18 UMN026 (ExPEC)
ebr  Escherichia coli B REL606
ecob  Escherichia coli B C3029
ebl  Escherichia coli BL21(DE3)
ebe  Escherichia coli BL21(DE3)
ebd  Escherichia coli BL21-Gold(DE3)pLysS AG
eci  Escherichia coli O18:K1:H7 UTI89 (UPEC)
eih  Escherichia coli O18:K1:H7 IHE3034 (ExPEC)
ecz  Escherichia coli O45:K1:H7 S88 (ExPEC)
ecc  Escherichia coli O6:K2:H1 CFT073 (UPEC)
elo  Escherichia coli O44:H18 042 (EAEC)
eln  Escherichia coli O83:H1 NRG 857C (AIEC)
ese  Escherichia coli O150:H5 SE15 (commensal)
ecl  Escherichia coli ATCC 8739
ekf  Escherichia coli KO11FL
eab  Escherichia coli ABU 83972
edh  Escherichia coli DH1
edj  Escherichia coli DH1
elu  Escherichia coli UM146
elw  Escherichia coli W
ell  Escherichia coli W
elc  Escherichia coli clone D i14
eld  Escherichia coli clone D i2
elf  Escherichia coli LF82
ecol  Escherichia coli LY180
ecoi  Escherichia coli O18:K1 PMV-1 (ExPEC)
ecoj  Escherichia coli JJ1886
efe  Escherichia fergusonii
eal  Escherichia albertii
ema  Escherichia marmotae
esz  Escherichia sp. E4742
eruy  Escherichia ruysiae
esf  Escherichia sp. F1
stm  Salmonella enterica subsp. enterica serovar Typhimurium LT2
seo  Salmonella enterica subsp. enterica serovar Typhimurium 14028S
sev  Salmonella enterica subsp. enterica serovar Typhimurium D23580
sey  Salmonella enterica subsp. enterica serovar Typhimurium SL1344
sem  Salmonella enterica subsp. enterica serovar Typhimurium T000240
sej  Salmonella enterica subsp. enterica serovar Typhimurium UK-1
seb  Salmonella enterica subsp. enterica serovar Typhimurium ST4/74
sef  Salmonella enterica subsp. enterica serovar Typhimurium 798
setu  Salmonella enterica subsp. enterica serovar Typhimurium U288
setc  Salmonella enterica subsp. enterica serovar Typhimurium var. 5- CFSAN001921
senr  Salmonella enterica subsp. enterica serovar Typhimurium DT2
seni  Salmonella enterica subsp. enterica serovar Typhimurium 138736
seen  Salmonella enterica subsp. enterica serovar 4,[5],12:i:- 08-1736
spt  Salmonella enterica subsp. enterica serovar Paratyphi A ATCC9150
sek  Salmonella enterica subsp. enterica serovar Paratyphi A AKU12601
spq  Salmonella enterica subsp. enterica serovar Paratyphi B
sei  Salmonella enterica subsp. enterica serovar Paratyphi C
seh  Salmonella enterica subsp. enterica serovar Heidelberg SL476
shb  Salmonella enterica subsp. enterica serovar Heidelberg B182
senh  Salmonella enterica subsp. enterica serovar Heidelberg CFSAN002069
seeh  Salmonella enterica subsp. enterica serovar Heidelberg 41578
see  Salmonella enterica subsp. enterica serovar Newport SL254
senn  Salmonella enterica subsp. enterica serovar Newport USMARC-S3124.1
sew  Salmonella enterica subsp. enterica serovar Schwarzengrund
sea  Salmonella enterica subsp. enterica serovar Agona SL483
sens  Salmonella enterica subsp. enterica serovar Agona 24249
sel  Salmonella enterica subsp. enterica serovar Gallinarum/pullorum RKS5078
sega  Salmonella enterica subsp. enterica serovar Gallinarum/pullorum CDC1983-67
set  Salmonella enterica subsp. enterica serovar Enteritidis P125109
sena  Salmonella enterica subsp. enterica serovar Enteritidis EC20090135
seno  Salmonella enterica subsp. enterica serovar Enteritidis EC20090193
senv  Salmonella enterica subsp. enterica serovar Enteritidis EC20090332
senq  Salmonella enterica subsp. enterica serovar Enteritidis EC20090531
senl  Salmonella enterica subsp. enterica serovar Enteritidis OLF-SE1-1019-1
senj  Salmonella enterica subsp. enterica serovar Javiana
seec  Salmonella enterica subsp. enterica serovar Cubana
seeb  Salmonella enterica subsp. enterica serovar Bareilly
seep  Salmonella enterica subsp. enterica serovar Pullorum
senb  Salmonella enterica subsp. enterica serovar Bovismorbificans
sene  Salmonella enterica subsp. enterica serovar Thompson
senc  Salmonella enterica subsp. enterica serovar Tennessee
ses  Salmonella enterica subsp. arizonae
sbg  Salmonella bongori NCTC 12419
sbz  Salmonella bongori N268-08
sbv  Salmonella bongori serovar 48:z41:--
salz  Salmonella sp. SSDFZ69
sbo  Shigella boydii Sb227 (serotype 4)
shq  Shigella sp. PAMC 28760
shig  Shigella sp. PIB
enl  Enterobacter cloacae subsp. dissolvens SDM
ecle  Enterobacter cloacae ECNIH2
ecln  Enterobacter cloacae ECNIH4
ecli  Enterobacter cloacae ECNIH5
eclx  Enterobacter hormaechei subsp. xiangfangensis 34399
ecly  Enterobacter hormaechei subsp. steigerwaltii
eclz  Enterobacter hormaechei subsp. hormaechei
eclo  Enterobacter hormaechei NCTC 9394
ehm  Enterobacter hormaechei CAV1176
exf  Enterobacter hormaechei subsp. xiangfangensis
ecla  Enterobacter hormaechei subsp. hoffmannii ECNIH3
eclc  Enterobacter hormaechei subsp. hoffmannii ECR091
eau  Enterobacter asburiae L1
ekb  Enterobacter kobei DSM 13645
eno  Enterobacter kobei ENHKU01
elg  Enterobacter ludwigii EN-119
ecan  Enterobacter cancerogenus
echg  Enterobacter chengduensis
esh  Enterobacter sichuanensis
ept  Enterobacter pasteurii
echu  Enterobacter chuandaensis
ent  Enterobacter sp. 638
eas  Enterobacter soli
lni  Enterobacter sp. SGAir0187
ebg  Enterobacter bugandensis
end  Enterobacter sp. ODB01
enz  Enterobacter sp. T2
ens  Enterobacter sp. DSM 30060
enk  Enterobacter sp. AN-K1
ehu  Enterobacter huaxiensis
emor  Enterobacter mori
enb  Enterobacter sp. N18-03635
equ  Enterobacter quasiroggenkampii
epu  Enterobacter pseudoroggenkampii
edy  Enterobacter dykesii
eax  Enterobacter adelaidei
ente  Enterobacter sp. SES19
enty  Enterobacter sp. YSU
enj  Enterobacter sp. PGRG2
csk  Cronobacter sakazakii ES15
csz  Cronobacter sakazakii Sp291
csj  Cronobacter sakazakii ATCC 29544
ccon  Cronobacter condimenti
cdm  Cronobacter dublinensis
csi  Cronobacter malonaticus CMCC45402
cmj  Cronobacter malonaticus LMG 23826
cui  Cronobacter universalis
cmw  Cronobacter muytjensii
ctu  Cronobacter turicensis
kpn  Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52)
kpu  Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 (serotype K1)
kpm  Klebsiella pneumoniae subsp. pneumoniae HS11286
kpp  Klebsiella pneumoniae subsp. pneumoniae 1084 (serotype K1)
kph  Klebsiella pneumoniae subsp. pneumoniae KPNIH24
kpz  Klebsiella pneumoniae subsp. pneumoniae KPNIH27
kpv  Klebsiella pneumoniae subsp. pneumoniae KPNIH29
kpw  Klebsiella pneumoniae subsp. pneumoniae KPNIH30
kpy  Klebsiella pneumoniae subsp. pneumoniae KPNIH31
kpg  Klebsiella pneumoniae subsp. pneumoniae KPNIH32
kpc  Klebsiella pneumoniae subsp. pneumoniae KPNIH10
kpq  Klebsiella pneumoniae subsp. pneumoniae KPR0928
kpt  Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1
kpo  Klebsiella pneumoniae KCTC 2242
kpr  Klebsiella pneumoniae subsp. rhinoscleromatis SB3432
kpj  Klebsiella pneumoniae JM45
kpa  Klebsiella pneumoniae 30660/NJST258_1
kps  Klebsiella pneumoniae 30684/NJST258_2
kpx  Klebsiella pneumoniae PMK1
kpb  Klebsiella pneumoniae blaNDM-1
kpne  Klebsiella pneumoniae 32192
kpnu  Klebsiella pneumoniae 34618
kpnk  Klebsiella pneumoniae Kp52.145
kva  Klebsiella variicola At-22
kpe  Klebsiella variicola 342
kvd  Klebsiella variicola DX120E
kvq  Klebsiella variicola DSM 15968
kqu  Klebsiella quasipneumoniae
kqv  Klebsiella quasivariicola
kox  Klebsiella michiganensis KCTC 1686
koe  Klebsiella michiganensis E718
kom  Klebsiella michiganensis M1
kok  Klebsiella oxytoca KONIH1
koc  Klebsiella oxytoca CAV1374
eae  Klebsiella aerogenes KCTC 2190
ear  Klebsiella aerogenes EA1509E
kll  Klebsiella sp. LTGPAF-6F
klw  Klebsiella huaxiensis
kar  Klebsiella africana
kgr  Klebsiella grimontii
kpas  Klebsiella pasteurii
klc  Klebsiella sp. CTHL.F3a
klm  Klebsiella sp. M5al
klp  Klebsiella sp. MPUS7
klx  Klebsiella sp. PCX
ron  Raoultella ornithinolytica S12
cro  Citrobacter rodentium
cko  Citrobacter koseri
cfd  Citrobacter freundii CFNIH1
cbra  Citrobacter braakii
cwe  Citrobacter werkmanii
cyo  Citrobacter youngae
cpot  Citrobacter portucalensis
cfq  Citrobacter freundii complex sp. CFNIH3
csed  Citrobacter sedlakii
cama  Citrobacter amalonaticus Y19
caf  Citrobacter amalonaticus FDAARGOS_165
cif  Citrobacter sp. FDAARGOS_156
cir  Citrobacter sp. CFNIH10
cie  Citrobacter sp. CRE-46
cpar  Citrobacter pasteurii
ctel  Citrobacter telavivensis
citz  Citrobacter tructae
cars  Citrobacter arsenatis
cix  Citrobacter sp. XT1-2-2
cib  Citrobacter sp. TSA-1
cens  Citrobacter enshiensis
citr  Citrobacter sp. LUTT5
ciq  Citrobacter sp. TBCP-5362
ciy  Citrobacter sp. Y3
esc  Enterobacter lignolyticus SCF1
kle  Enterobacter lignolyticus G5
kas  Kluyvera ascorbata
klu  Kluyvera sp. CRP
kcy  Kluyvera cryocrescens
kgn  Kluyvera genomosp. 3
lax  Leclercia adecarboxylata
lei  Leclercia sp. LSNIH1
leh  Leclercia sp. LSNIH3
lee  Leclercia sp. W17
ler  Leclercia sp. Colony189
lea  Leclercia sp. J807
ley  Leclercia sp. W6
laz  Lelliottia amnigena
lef  Lelliottia jeotgali
lew  Lelliottia sp. WB101
buf  Buttiauxella sp. 3AFRM03
bage  Buttiauxella agrestis
bft  Buttiauxella ferragutiae
ahn  Atlantibacter hermannii
asub  Atlantibacter subterraneus
yre  Yokenella regensburgei
sgoe  Scandinavium goeteborgense
psgc  Pseudocitrobacter corydidari
scol  Siccibacter colletis
pvj  Pseudescherichia vulneris
supe  Superficieibacter sp. HKU1
toe  Trabulsiella odontotermitis
fpul  Franconibacter pulveris
ebf  Enterobacteriaceae bacterium FGI 57
ebu  Enterobacteriaceae bacterium S05
rox  Rahnella sikkimica
pmas  Pelagerythrobacter marinus
 » show all
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
PMID:11274125
  Authors
Kobayashi K, Tsukagoshi N, Aono R
  Title
Suppression of hypersensitivity of Escherichia coli acrB mutant to organic solvents by integrational activation of the acrEF operon with the IS1 or IS2 element.
  Journal
J Bacteriol 183:2646-53 (2001)
DOI:10.1128/JB.183.8.2646-2653.2001
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
PMID:14706082
  Authors
Poole K
  Title
Efflux-mediated multiresistance in Gram-negative bacteria.
  Journal
Clin Microbiol Infect 10:12-26 (2004)
DOI:10.1111/j.1469-0691.2004.00763.x
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