KEGG   MODULE: M00696
Entry
M00696            Signature Module                                 
Name
Multidrug resistance, efflux pump AcrEF-TolC
Definition
K18140 K18141+K18142+K12340
Diagram
M00696

Orthology
K18140  
envR, acrS; TetR/AcrR family transcriptional regulator, acrEF/envCD operon repressor [COG:COG1309]
K18141  
acrE; membrane fusion protein [COG:COG0845] [TC:2.A.6.2]
K18142  
acrF; multidrug efflux pump [COG:COG0841] [TC:2.A.6.2]
K12340  
tolC; outer membrane channel protein [COG:COG1538] [TC:1.B.17 2.A.6.2]
Class
Signature modules; Gene set; Drug resistance
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
PMID:11274125
  Authors
Kobayashi K, Tsukagoshi N, Aono R
  Title
Suppression of hypersensitivity of Escherichia coli acrB mutant to organic solvents by integrational activation of the acrEF operon with the IS1 or IS2 element.
  Journal
J Bacteriol 183:2646-53 (2001)
DOI:10.1128/JB.183.8.2646-2653.2001
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
PMID:14706082
  Authors
Poole K
  Title
Efflux-mediated multiresistance in Gram-negative bacteria.
  Journal
Clin Microbiol Infect 10:12-26 (2004)
DOI:10.1111/j.1469-0691.2004.00763.x
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