KEGG   MODULE: M00697
Entry
M00697            Signature Module                                 
Name
Multidrug resistance, efflux pump MdtEF-TolC
Definition
K07690 K18898+K18899+K12340
Diagram
M00697  Multidrug resistance, efflux pump MdtEF-TolC
M00697

Class
Signature modules; Gene set; Drug resistance
Orthology
K07690  
evgA, bvgA; two-component system, NarL family, response regulator EvgA [COG:COG2197] [GO:0000156]
K18898  
mdtE; membrane fusion protein [COG:COG0845] [TC:8.A.1.6.3 2.A.6.2]
K18899  
mdtF; multidrug efflux pump [COG:COG0841] [TC:2.A.6.2.13]
K12340  
tolC; outer membrane channel protein [COG:COG1538] [TC:1.B.17 2.A.6.2]
Complete
eco  Escherichia coli K-12 MG1655
ecj  Escherichia coli K-12 W3110
ecd  Escherichia coli K-12 DH10B
ebw  Escherichia coli K-12 BW2952
ecok  Escherichia coli K-12 MDS42
ecoc  Escherichia coli K-12 C3026
ece  Escherichia coli O157:H7 EDL933 (EHEC)
ecs  Escherichia coli O157:H7 Sakai (EHEC)
ecf  Escherichia coli O157:H7 EC4115 (EHEC)
etw  Escherichia coli O157:H7 TW14359 (EHEC)
elx  Escherichia coli O157:H7 Xuzhou21 (EHEC)
eoi  Escherichia coli O111:H- 11128 (EHEC)
eoj  Escherichia coli O26:H11 11368 (EHEC)
eoh  Escherichia coli O103:H2 12009 (EHEC)
ecoo  Escherichia coli O145:H28 RM13514 (EHEC)
ecoh  Escherichia coli O145:H28 RM13516 (EHEC)
esl  Escherichia coli O104:H4 2011C-3493 (EAEC)
eso  Escherichia coli O104:H4 2009EL-2071 (EAEC)
esm  Escherichia coli O104:H4 2009EL-2050 (EAEC)
eck  Escherichia coli 55989 (EAEC)
ecg  Escherichia coli O127:H6 E2348/69 (EPEC)
eok  Escherichia coli O55:H7 CB9615 (EPEC)
elr  Escherichia coli O55:H7 RM12579 (EPEC)
elh  Escherichia coli O78:H11:K80 H10407 (ETEC)
ecw  Escherichia coli O139:H28 E24377A (ETEC)
eun  Escherichia coli UMNK88 (ETEC, porcine)
ecp  Escherichia coli O6:K15:H31 536 (UPEC)
ena  Escherichia coli NA114 (UPEC)
ecos  Escherichia coli O25b:K100:H4-ST131 EC958 (UPEC)
ecv  Escherichia coli APEC O1 (APEC)
ecoa  Escherichia coli APEC O78 (APEC)
ecx  Escherichia coli O9 HS (commensal)
ecm  Escherichia coli SMS-3-5 (environmental)
ecy  Escherichia coli O152:H28 SE11 (commensal)
ecr  Escherichia coli O8 IAI1 (commensal)
ecq  Escherichia coli O81 ED1a (commensal)
eum  Escherichia coli O17:K52:H18 UMN026 (ExPEC)
ect  Escherichia coli O7:K1 IAI39 (ExPEC)
eoc  Escherichia coli O7:K1 CE10
ebr  Escherichia coli B REL606
ecob  Escherichia coli B C3029
ebl  Escherichia coli BL21(DE3)
ebe  Escherichia coli BL21(DE3)
ebd  Escherichia coli BL21-Gold(DE3)pLysS AG
eci  Escherichia coli O18:K1:H7 UTI89 (UPEC)
eih  Escherichia coli O18:K1:H7 IHE3034 (ExPEC)
ecz  Escherichia coli O45:K1:H7 S88 (ExPEC)
ecc  Escherichia coli O6:K2:H1 CFT073 (UPEC)
eln  Escherichia coli O83:H1 NRG 857C (AIEC)
ese  Escherichia coli O150:H5 SE15 (commensal)
ecl  Escherichia coli ATCC 8739
ekf  Escherichia coli KO11FL
eab  Escherichia coli ABU 83972
edh  Escherichia coli DH1
edj  Escherichia coli DH1
elu  Escherichia coli UM146
elw  Escherichia coli W
ell  Escherichia coli W
elc  Escherichia coli clone D i14
eld  Escherichia coli clone D i2
elp  Escherichia coli P12b
elf  Escherichia coli LF82
ecol  Escherichia coli LY180
ecoi  Escherichia coli O18:K1 PMV-1 (ExPEC)
ecoj  Escherichia coli JJ1886
esf  Escherichia sp. F1
sfn  Shigella flexneri 2003036
sfs  Shigella flexneri Shi06HN006 (serotype Yv)
sft  Shigella flexneri NCTC1 (serotype 2a)
ssn  Shigella sonnei Ss046
sbo  Shigella boydii Sb227 (serotype 4)
sbc  Shigella boydii CDC 3083-94 (serotype 18)
sdy  Shigella dysenteriae Sd197
shq  Shigella sp. PAMC 28760
shig  Shigella sp. PIB
cfd  Citrobacter freundii CFNIH1
cbra  Citrobacter braakii
cyo  Citrobacter youngae
cpot  Citrobacter portucalensis
cie  Citrobacter sp. CRE-46
citz  Citrobacter tructae
cars  Citrobacter arsenatis
cix  Citrobacter sp. XT1-2-2
cib  Citrobacter sp. TSA-1
citr  Citrobacter sp. LUTT5
 » show all
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
PMID:11914367
  Authors
Nishino K, Yamaguchi A
  Title
EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli.
  Journal
J Bacteriol 184:2319-23 (2002)
DOI:10.1128/JB.184.8.2319-2323.2002
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
PMID:14706082
  Authors
Poole K
  Title
Efflux-mediated multiresistance in Gram-negative bacteria.
  Journal
Clin Microbiol Infect 10:12-26 (2004)
DOI:10.1111/j.1469-0691.2004.00763.x
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