| Entry |
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| Name |
Tetracycline resistance, efflux pump Tet38
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| Definition |
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| Diagram |
| M00704 | Tetracycline resistance, efflux pump Tet38 |
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| Class |
Signature modules; Gene set; Drug resistance
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| Orthology |
mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA [COG: COG1846] tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter [COG: COG0477] [TC: 2.A.1.3] |
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| Complete |
| sau | Staphylococcus aureus subsp. aureus N315 (MRSA/VSSA) |
| sav | Staphylococcus aureus subsp. aureus Mu50 (MRSA/VISA) |
| saw | Staphylococcus aureus subsp. aureus Mu3 (MRSA/hetero-VISA) |
| sah | Staphylococcus aureus subsp. aureus JH1 (MRSA/VSSA) |
| saj | Staphylococcus aureus subsp. aureus JH9 (MRSA/VISA) |
| sam | Staphylococcus aureus subsp. aureus MW2 (CA-MRSA) |
| sas | Staphylococcus aureus subsp. aureus MSSA476 (MSSA) |
| sar | Staphylococcus aureus subsp. aureus MRSA252 (MRSA) |
| sac | Staphylococcus aureus subsp. aureus COL (MRSA) |
| sax | Staphylococcus aureus subsp. aureus USA300_TCH1516 (CA-MRSA) |
| saa | Staphylococcus aureus subsp. aureus USA300_FPR3757 (CA-MRSA) |
| sao | Staphylococcus aureus subsp. aureus NCTC8325 |
| sae | Staphylococcus aureus subsp. aureus Newman |
| sad | Staphylococcus aureus subsp. aureus ED98 |
| suu | Staphylococcus aureus subsp. aureus M013 (CA-MRSA) |
| suv | Staphylococcus aureus subsp. aureus VC40 |
| sue | Staphylococcus aureus subsp. aureus ED133 |
| suj | Staphylococcus aureus subsp. aureus JKD6159 (CA-MRSA) |
| suk | Staphylococcus aureus subsp. aureus JKD6008 (MRSA/VISA) |
| suc | Staphylococcus aureus subsp. aureus ECT-R 2 (MSSA) |
| sut | Staphylococcus aureus subsp. aureus T0131 (MRSA) |
| suq | Staphylococcus aureus subsp. aureus TCH60 |
| suz | Staphylococcus aureus subsp. aureus 11819-97 (CA-MRSA) |
| sud | Staphylococcus aureus subsp. aureus 71193 (MSSA) |
| sux | Staphylococcus aureus subsp. aureus HO 5096 0412 (MRSA) |
| suw | Staphylococcus aureus subsp. aureus TW20 (MRSA) |
| sug | Staphylococcus aureus subsp. aureus ST398 (MRSA) |
| suf | Staphylococcus aureus subsp. aureus LGA251 (MRSA) |
| saua | Staphylococcus aureus subsp. aureus 55/2053 |
| saue | Staphylococcus aureus subsp. aureus 6850 (MSSA) |
| saun | Staphylococcus aureus subsp. aureus CN1 (CA-MRSA) |
| saus | Staphylococcus aureus subsp. aureus SA40 (CA-MRSA) |
| sauu | Staphylococcus aureus subsp. aureus SA957 (CA-MRSA) |
| saug | Staphylococcus aureus subsp. aureus SA268 (CA-MRSA) |
| sauz | Staphylococcus aureus subsp. aureus Z172 (MRSA/VISA) |
| sauf | Staphylococcus aureus subsp. aureus FDAARGOS_5 |
| sab | Staphylococcus aureus RF122 |
| suy | Staphylococcus aureus 04-02981 (MRSA) |
| saub | Staphylococcus aureus 08BA02176 (LA-MRSA) |
| saum | Staphylococcus aureus M1 (MRSA) |
| sauc | Staphylococcus aureus CA-347 (MRSA) |
| saur | Staphylococcus aureus Bmb9393 (MRSA) |
| saui | Staphylococcus aureus USA300-ISMMS1 (MRSA) |
| saud | Staphylococcus aureus 502A |
| sams | Staphylococcus aureus MS4 |
| suh | Staphylococcus argenteus |
| sep | Staphylococcus epidermidis ATCC 12228 |
| sepp | Staphylococcus epidermidis PM221 |
| shu | Staphylococcus hyicus |
| ssch | Staphylococcus schleiferi 1360-13 |
| sscz | Staphylococcus schleiferi 2317-03 |
| sagq | Staphylococcus agnetis |
| slz | Staphylococcus lutrae |
| shom | Staphylococcus hominis |
| smus | Staphylococcus muscae |
| schr | Staphylococcus chromogenes |
| ssh | Staphylococcus schweitzeri |
| ssac | Staphylococcus saccharolyticus |
| srot | Staphylococcus roterodami |
| sff | Mammaliicoccus fleurettii |
| mlen | Mammaliicoccus lentus |
| mvt | Mammaliicoccus vitulinus |
| mequ | Macrococcus equipercicus |
| pjd | Paenibacillus sp. JDR-2 |
| plyc | Paenibacillus lycopersici |
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| Comment |
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
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| Reference |
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| Authors |
Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC |
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| Title |
MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. |
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| Journal |
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| Reference |
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| Authors |
Fernandez L, Hancock RE |
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| Title |
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. |
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| Journal |
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| LinkDB |
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