| Entry |
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| Name |
Multidrug resistance, efflux pump MepA
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| Definition |
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| Diagram |
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| Orthology |
mepR; MarR family transcriptional regulator, repressor for mepA [COG: COG1846] |
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| Class |
Signature modules; Gene set; Drug resistance
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| Comment |
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
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| Reference |
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| Authors |
McAleese F, Petersen P, Ruzin A, Dunman PM, Murphy E, Projan SJ, Bradford PA |
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| Title |
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline. |
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| Journal |
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| Reference |
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| Authors |
Schindler BD, Seo SM, Jacinto PL, Kumaraswami M, Birukou I, Brennan RG, Kaatz GW |
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| Title |
Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene. |
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| Journal |
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| Reference |
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| Authors |
Fernandez L, Hancock RE |
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| Title |
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. |
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| Journal |
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| LinkDB |
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