KEGG   MODULE: M00705
Entry
M00705            Signature Module                                 
Name
Multidrug resistance, efflux pump MepA
Definition
K18909 K18908
Diagram
M00705  Multidrug resistance, efflux pump MepA
M00705

Class
Signature modules; Gene set; Drug resistance
Orthology
K18909  
mepR; MarR family transcriptional regulator, repressor for mepA [COG:COG1846]
K18908  
mepA; multidrug efflux pump [COG:COG0534] [TC:2.A.66.1.13]
Complete
sdo  Sulfitobacter donghicola
bcir  Niallia circulans
ntx  Niallia taxi
lyc  Lysinibacillus sp. CD3-6
psyo  Psychrobacillus glaciei
gaj  Gottfriedia acidiceleris
sau  Staphylococcus aureus subsp. aureus N315 (MRSA/VSSA)
sav  Staphylococcus aureus subsp. aureus Mu50 (MRSA/VISA)
saw  Staphylococcus aureus subsp. aureus Mu3 (MRSA/hetero-VISA)
sah  Staphylococcus aureus subsp. aureus JH1 (MRSA/VSSA)
saj  Staphylococcus aureus subsp. aureus JH9 (MRSA/VISA)
sam  Staphylococcus aureus subsp. aureus MW2 (CA-MRSA)
sas  Staphylococcus aureus subsp. aureus MSSA476 (MSSA)
sar  Staphylococcus aureus subsp. aureus MRSA252 (MRSA)
sac  Staphylococcus aureus subsp. aureus COL (MRSA)
sax  Staphylococcus aureus subsp. aureus USA300_TCH1516 (CA-MRSA)
saa  Staphylococcus aureus subsp. aureus USA300_FPR3757 (CA-MRSA)
sao  Staphylococcus aureus subsp. aureus NCTC8325
sae  Staphylococcus aureus subsp. aureus Newman
sad  Staphylococcus aureus subsp. aureus ED98
suu  Staphylococcus aureus subsp. aureus M013 (CA-MRSA)
suv  Staphylococcus aureus subsp. aureus VC40
sue  Staphylococcus aureus subsp. aureus ED133
suj  Staphylococcus aureus subsp. aureus JKD6159 (CA-MRSA)
suk  Staphylococcus aureus subsp. aureus JKD6008 (MRSA/VISA)
suc  Staphylococcus aureus subsp. aureus ECT-R 2 (MSSA)
sut  Staphylococcus aureus subsp. aureus T0131 (MRSA)
suq  Staphylococcus aureus subsp. aureus TCH60
suz  Staphylococcus aureus subsp. aureus 11819-97 (CA-MRSA)
sud  Staphylococcus aureus subsp. aureus 71193 (MSSA)
sux  Staphylococcus aureus subsp. aureus HO 5096 0412 (MRSA)
suw  Staphylococcus aureus subsp. aureus TW20 (MRSA)
sug  Staphylococcus aureus subsp. aureus ST398 (MRSA)
suf  Staphylococcus aureus subsp. aureus LGA251 (MRSA)
saua  Staphylococcus aureus subsp. aureus 55/2053
saue  Staphylococcus aureus subsp. aureus 6850 (MSSA)
saun  Staphylococcus aureus subsp. aureus CN1 (CA-MRSA)
saus  Staphylococcus aureus subsp. aureus SA40 (CA-MRSA)
sauu  Staphylococcus aureus subsp. aureus SA957 (CA-MRSA)
saug  Staphylococcus aureus subsp. aureus SA268 (CA-MRSA)
sauz  Staphylococcus aureus subsp. aureus Z172 (MRSA/VISA)
sauf  Staphylococcus aureus subsp. aureus FDAARGOS_5
sab  Staphylococcus aureus RF122
suy  Staphylococcus aureus 04-02981 (MRSA)
saub  Staphylococcus aureus 08BA02176 (LA-MRSA)
saum  Staphylococcus aureus M1 (MRSA)
sauc  Staphylococcus aureus CA-347 (MRSA)
saur  Staphylococcus aureus Bmb9393 (MRSA)
saui  Staphylococcus aureus USA300-ISMMS1 (MRSA)
saud  Staphylococcus aureus 502A
sams  Staphylococcus aureus MS4
suh  Staphylococcus argenteus
sha  Staphylococcus haemolyticus JCSC1435
shh  Staphylococcus haemolyticus Sh29/312/L2
ssp  Staphylococcus saprophyticus
sca  Staphylococcus carnosus subsp. carnosus
slg  Staphylococcus lugdunensis HKU09-01
sln  Staphylococcus lugdunensis N920143
swa  Staphylococcus warneri
spas  Staphylococcus pasteuri
scv  Staphylococcus condimenti
scar  Staphylococcus caprae
ssh  Staphylococcus schweitzeri
ssim  Staphylococcus simiae
stas  Staphylococcus taiwanensis
seda  Staphylococcus edaphicus
sdev  Staphylococcus devriesei
srot  Staphylococcus roterodami
mboc  Macrococcus bovicus
lmo  Listeria monocytogenes EGD-e (serotype 1/2a)
lmn  Listeria monocytogenes 08-5578 (serotype 1/2a)
lmy  Listeria monocytogenes 08-5923 (serotype 1/2a)
lmt  Listeria monocytogenes 10403S (serotype 1/2a)
lmoc  Listeria monocytogenes SLCC5850 (serotype 1/2a)
lmoe  Listeria monocytogenes La111 (serotype 1/2a)
lmob  Listeria monocytogenes N53-1 (serotype 1/2a)
lmod  Listeria monocytogenes EGD (serotype 1/2a)
lmow  Listeria monocytogenes WSLC1001 (serotype 1/2a)
lmoq  Listeria monocytogenes 6179 (serotype 1/2a)
lmr  Listeria monocytogenes R479a (serotype 1/2a)
lmom  Listeria monocytogenes Lm60 (serotype 1/2a)
lmf  Listeria monocytogenes F2365 (serotype 4b)
lmc  Listeria monocytogenes CLIP 80459 (serotype 4b)
lmog  Listeria monocytogenes serotype 4b LL195
lmp  Listeria monocytogenes 07PF0776 (serotype 4b)
lmol  Listeria monocytogenes L312 (serotype 4b)
lmoz  Listeria monocytogenes J1-220 (serotype 4b)
lmox  Listeria monocytogenes WSLC1042 (serotype 4b)
lmh  Listeria monocytogenes HCC23 (serotype 4a)
lmq  Listeria monocytogenes M7 (serotype 4a)
lml  Listeria monocytogenes L99 (serotype 4a)
lmg  Listeria monocytogenes FSL R2-561
lms  Listeria monocytogenes Finland 1998
lmj  Listeria monocytogenes J0161
lmw  Listeria monocytogenes SLCC2755 (serotype 1/2b)
lmx  Listeria monocytogenes SLCC2372 (serotype 1/2c)
lmz  Listeria monocytogenes serotype 7 SLCC2482
lmon  Listeria monocytogenes SLCC2376 (serotype 4c)
lmos  Listeria monocytogenes SLCC7179 (serotype 3a)
lmoo  Listeria monocytogenes SLCC2378 (serotype 4e)
lmoy  Listeria monocytogenes SLCC2479 (serotype 3c)
lmot  Listeria monocytogenes SLCC2540 (serotype 3b)
lmoa  Listeria monocytogenes ATCC 19117 (serotype 4d)
lmok  Listeria monocytogenes NE dc2014
lmv  Listeria monocytogenes CFSAN006122
lin  Listeria innocua (serotype 6a)
lwe  Listeria welshimeri
lsg  Listeria seeligeri
liv  Listeria ivanovii subsp. ivanovii PAM 55
lii  Listeria ivanovii subsp. ivanovii WSLC 3010
liw  Listeria ivanovii WSLC3009
lia  Listeria ivanovii subsp. londoniensis WSLC 30167
lio  Listeria ivanovii subsp. londoniensis WSLC 30151
lwi  Listeria weihenstephanensis
lmar  Listeria marthii
lnw  Listeria newyorkensis
bths  Brochothrix thermosphacta
pjd  Paenibacillus sp. JDR-2
ppy  Paenibacillus polymyxa E681
ppol  Paenibacillus polymyxa CR1
pdu  Paenibacillus durus
pbd  Paenibacillus borealis
pgm  Paenibacillus graminis
pod  Paenibacillus odorifer
paen  Paenibacillus sp. FSL P4-0081
paef  Paenibacillus sp. FSL R5-0345
paeq  Paenibacillus sp. FSL R5-0912
pste  Paenibacillus stellifer
paeh  Paenibacillus sp. FSL H7-0357
paej  Paenibacillus sp. FSL H7-0737
pri  Paenibacillus riograndensis
pson  Paenibacillus sonchi
ppeo  Paenibacillus peoriae
pdh  Paenibacillus donghaensis
paih  Paenibacillus sp. IHB B 3084
palb  Paenibacillus albus
pchi  Paenibacillus chitinolyticus
plyc  Paenibacillus lycopersici
ptri  Paenibacillus tritici
ptj  Paenibacillus tianjinensis
pmah  Paenibacillus marchantiae
ppab  Paenibacillus pabuli
phex  Paenibacillus hexagrammi
pezz  Paenibacillus sp. E222
ptun  Paenibacillus tundrae
ptac  Paenibacillus taichungensis
saca  Saccharibacillus brassicae
vij  Viridibacillus arvi
lla  Lactococcus lactis subsp. lactis Il1403
llk  Lactococcus lactis subsp. lactis KF147
llt  Lactococcus lactis subsp. lactis CV56
lls  Lactococcus lactis subsp. lactis IO-1
lld  Lactococcus lactis subsp. lactis KLDS 4.0325
llx  Lactococcus lactis subsp. lactis NCDO 2118
llj  Lactococcus lactis AI06
llm  Lactococcus lactis subsp. cremoris MG1363
llc  Lactococcus lactis subsp. cremoris SK11
llr  Lactococcus lactis subsp. cremoris A76
lln  Lactococcus lactis subsp. cremoris NZ9000
lli  Lactococcus lactis subsp. cremoris UC509.9
llw  Lactococcus cremoris subsp. cremoris KW2
lti  Lactococcus taiwanensis
edu  Enterococcus durans
ega  Enterococcus gallinarum
eav  Enterococcus avium
eie  Enterococcus innesii
eni  Enterococcus sp. CR-Ec1
ede  Enterococcus devriesei
cac  Clostridium acetobutylicum ATCC 824
cae  Clostridium acetobutylicum DSM 1731
cay  Clostridium acetobutylicum EA 2018
cpf  Clostridium perfringens ATCC 13124
cbe  Clostridium beijerinckii NCIMB 8052
cbz  Clostridium beijerinckii ATCC 35702
cbei  Clostridium beijerinckii NCIMB 14988
ckl  Clostridium kluyveri DSM 555
ckr  Clostridium kluyveri NBRC 12016
clj  Clostridium ljungdahlii
csr  Clostridium saccharoperbutylacetonicum
cpat  Clostridium pasteurianum DSM 525 = ATCC 6013
cpae  Clostridium pasteurianum DSM 525 = ATCC 6013
csb  Clostridium saccharobutylicum
cah  Clostridium autoethanogenum
cbv  Clostridium baratii
csq  Clostridium scatologenes
cck  Clostridium carboxidivorans
cdrk  Clostridium drakei
cdy  Clostridium diolis
cmah  Clostridium manihotivorum
crw  Clostridium felsineum DSM 7320
cfb  Clostridium felsineum DSM 794
clom  Clostridium sp. MF28
cpro  Anaerotignum propionicum
psor  Paraclostridium sordellii
leif  Leifsonia sp. PS1209
lse  Leifsonia shinshuensis
leiz  Leifsonia sp. ZF2019
mprt  Microbacterium protaetiae
rfs  Rathayibacter festucae
cub  Curtobacterium sp. BH-2-1-1
cqf  Curtobacterium flaccumfaciens
cuy  Curtobacterium sp. YC1
cpoi  Curtobacterium poinsettiae
frp  Frondihabitans sp. PAMC 28766
fsb  Frondihabitans sucicola
agy  Agromyces aureus
alav  Agromyces larvae
huw  Humibacter ginsenosidimutans
plap  Plantibacter sp. PA-3-X8
pflu  Plantibacter flavus
llut  Leucobacter luti
lall  Leucobacter allii
frn  Frigoribacterium sp. NBH87
suba  Subtercola endophyticus
are  Arthrobacter sp. ERGS1:01
acit  Arthrobacter citreus
artl  Arthrobacter sp. Helios
ske  Sanguibacter keddieii
sbil  Sanguibacter biliveldensis
celn  Cellulomonas sp. NTE-D12
oek  Oerskovia sp. KBS0722
ume  Umezawaea sp. Da 62-37
afs  Actinoplanes friuliensis
jat  Jatrophihabitans sp. GAS493
str  Sebaldella termitidis
 » show all
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
PMID:15855508
  Authors
McAleese F, Petersen P, Ruzin A, Dunman PM, Murphy E, Projan SJ, Bradford PA
  Title
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.
  Journal
Antimicrob Agents Chemother 49:1865-71 (2005)
DOI:10.1128/AAC.49.5.1865-1871.2005
Reference
PMID:23749979
  Authors
Schindler BD, Seo SM, Jacinto PL, Kumaraswami M, Birukou I, Brennan RG, Kaatz GW
  Title
Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene.
  Journal
J Bacteriol 195:3651-62 (2013)
DOI:10.1128/JB.00565-13
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
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