KEGG   MODULE: M00901
Entry
M00901            Pathway   Module                                 
Name
Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Definition
K23665 K23666 K23667 K23668
Diagram
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
M00901

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other fungal compounds
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K23665  
FMQA; fumiquinazoline F synthetase [EC:6.3.2.-] [RN:R12417]
K23666  
FMQB; fumiquinazoline F monooxygenase [EC:1.14.14.-] [RN:R12418]
K23667  
FMQC; fumiquinazoline A synthase [EC:6.3.2.-] [RN:R12419]
K23668  
FMQD; fumiquinazoline A oxidase [EC:1.5.3.-] [RN:R12420]
Complete
afm  Aspergillus fumigatus
act  Aspergillus clavatus
pdp  Penicillium digitatum
Reaction
R12417  
R12418  
R12419  
R12420  
R12421  
Compound
C00078  L-Tryptophan
C00108  Anthranilate
C00041  L-Alanine
C22145  Fumiquinazoline F
C22146  Fumiquinazoline F-indoline-2',3'-diol
C22147  Fumiquinazoline A
C22148  Fumiquinazoline C
C22149  Fumiquinazoline D
Reference
PMID:20804163
  Authors
Ames BD, Liu X, Walsh CT
  Title
Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.
  Journal
Biochemistry 49:8564-76 (2010)
DOI:10.1021/bi1012029
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