KEGG   MODULE: M00913
Entry
M00913            Pathway   Module                                 
Name
Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate
Definition
K00606 K00077
K13367 K00128
K01918
Diagram
M00913  Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate
M00913

Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00770  Pantothenate and CoA biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Orthology
K00606  
3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] [RN:R01226]
K00077  
2-dehydropantoate 2-reductase [EC:1.1.1.169] [RN:R02472]
K13367  
polyamine oxidase [EC:1.5.3.17] [RN:R09076]
K00128  
aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [RN:R00904]
K01918  
pantoate--beta-alanine ligase [EC:6.3.2.1] [RN:R02473]
Complete
sce  Saccharomyces cerevisiae (budding yeast)
seub  Saccharomyces eubayanus
spao  Saccharomyces paradoxus
ago  Eremothecium gossypii
kla  Kluyveromyces lactis
kmx  Kluyveromyces marxianus
lth  Lachancea thermotolerans
zro  Zygosaccharomyces rouxii
cgr  Nakaseomyces glabratus
ncs  Naumovozyma castellii
ndi  Naumovozyma dairenensis
tgb  Torulaspora globosa
tdl  Torulaspora delbrueckii
kaf  Kazachstania africana
kng  Huiozyma naganishii
zmk  Zygotorulaspora mrakii
dha  Debaryomyces hansenii
pic  Scheffersomyces stipitis
pgu  Meyerozyma guilliermondii
lel  Lodderomyces elongisporus
lbg  Lodderomyces beijingensis
cal  Candida albicans
ctp  Candida tropicalis
cot  Candida orthopsilosis
cdu  Candida dubliniensis
cten  Yamadazyma tenuis
clu  Clavispora lusitaniae ATCC 42720
clus  Clavispora lusitaniae CBS 6936
caur  Candidozyma auris
asau  Australozyma saopauloensis
ppa  Komagataella phaffii
pkz  Pichia kudriavzevii
bnn  Brettanomyces nanus
bbrx  Brettanomyces bruxellensis
opa  Ogataea parapolymorpha
yli  Yarrowia lipolytica
fvr  Fusarium verticillioides
fmu  Fusarium musae
ssl  Sclerotinia sclerotiorum
bfu  Botrytis cinerea (gray mold)
psco  Mollisia scopiformis
pcs  Penicillium rubens
pdp  Penicillium digitatum
ffu  Fulvia fulva
cbet  Cercospora beticola
 » show all
Reaction
R01226  
R02472  
R09076  
R00904  
R02473  
Compound
C00141  3-Methyl-2-oxobutanoic acid
C00966  2-Dehydropantoate
C00522  (R)-Pantoate
C00750  Spermine
C05665  3-Aminopropanal
C00099  beta-Alanine
C00864  Pantothenate
Reference
PMID:11154694
  Authors
White WH, Gunyuzlu PL, Toyn JH
  Title
Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine.
  Journal
J Biol Chem 276:10794-800 (2001)
DOI:10.1074/jbc.M009804200
Reference
PMID:12586697
  Authors
White WH, Skatrud PL, Xue Z, Toyn JH
  Title
Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae.
  Journal
Genetics 163:69-77 (2003)
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