KEGG   MODULE: M00914
Entry
M00914            Pathway   Module                                 
Name
Coenzyme A biosynthesis, archaea, 2-oxoisovalerate => 4-phosphopantoate => CoA
Definition
K00606 K00077 K06982 K09722 K13038 K02201 K09735
Diagram
M00914  Coenzyme A biosynthesis, archaea, 2-oxoisovalerate => 4-phosphopantoate => CoA
M00914

Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00770  Pantothenate and CoA biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Orthology
K00606  
3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] [RN:R01226]
K00077  
2-dehydropantoate 2-reductase [EC:1.1.1.169] [RN:R02472]
K06982  
pantoate kinase [EC:2.7.1.169] [RN:R09378]
K09722  
4-phosphopantoate---beta-alanine ligase [EC:6.3.2.36] [RN:R09379]
K13038  
phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5] [RN:R04231 R03269]
K02201  
pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] [RN:R03035]
K09735  
GTP-dependent dephospho-CoA kinase [EC:2.7.1.237] [RN:R12608]
Complete
pfu  Pyrococcus furiosus DSM 3638
pfi  Pyrococcus furiosus COM1
pho  Pyrococcus horikoshii
pab  Pyrococcus abyssi
pyn  Pyrococcus sp. NA2
pya  Pyrococcus yayanosii
pys  Pyrococcus sp. ST04
tko  Thermococcus kodakarensis
ton  Thermococcus onnurineus
tga  Thermococcus gammatolerans
tsi  Thermococcus sibiricus
tba  Thermococcus barophilus
the  Thermococcus sp. 4557
tha  Thermococcus sp. AM4
thm  Thermococcus cleftensis
tlt  Thermococcus litoralis
ths  Thermococcus paralvinellae
tnu  Thermococcus nautili
tgy  Thermococcus guaymasensis
thv  Thermococcus sp. 2319x1
tch  Thermococcus chitonophagus
tpep  Thermococcus peptonophilus
tgg  Thermococcus gorgonarius
tbs  Thermococcus barossii
thh  Thermococcus sp. 5-4
tsl  Thermococcus siculi
ttd  Thermococcus thioreducens
tprf  Thermococcus profundus
trl  Thermococcus radiotolerans
tpaf  Thermococcus pacificus
thy  Thermococcus sp. P6
tic  Thermococcus indicus
tcq  Thermococcus camini
them  Thermococcus aciditolerans
thei  Thermococcus argininiproducens
tagg  Thermococcus aggregans
ppac  Palaeococcus pacificus
hsl  Halobacterium salinarum R1
hanr  Halobacterium salinarum NRC-34001
hhb  Halobacterium hubeiense
hags  Halobacterium sp. GSL-19
habo  Halobacterium sp. BOL4-2
hno  Halobacterium noricense
hlu  Halobacterium litoreum
hanx  Halobacterium sp. NMX12-1
halh  Halodesulfurarchaeum formicicum HTSR1
hhsr  Halodesulfurarchaeum formicicum HSR6
hsu  Halanaeroarchaeum sulfurireducens HSR2
hsf  Halanaeroarchaeum sulfurireducens M27-SA2
hahs  Halanaeroarchaeum sp. HSR-CO
salr  Salarchaeum sp. JOR-1
halr  Halarchaeum sp. CBA1220
hje  Halalkalicoccus jeotgali
hdo  Halococcus dombrowskii
halx  Halorussus limi
haxz  Halorussus gelatinilyticus
hayc  Halorussus salilacus
haxy  Halorussus vallis
sali  Salinarchaeum sp. Harcht-Bsk1
saim  Salinarchaeum sp. IM2453
hara  Natranaeroarchaeum sulfidigenes
hma  Haloarcula marismortui ATCC 43049
hsin  Haloarcula marismortui ATCC 33800
hhi  Haloarcula hispanica ATCC 33960
hhn  Haloarcula hispanica N601
hab  Haloarcula sp. CBA1115
hta  Haloarcula taiwanensis
halj  Haloarcula sp. JP-L23
hut  Halorhabdus utahensis
hti  Halorhabdus tiamatea
hasv  Halorhabdus sp. SVX81
habn  Halorhabdus sp. BNX81
hmu  Halomicrobium mukohataei
halz  Halomicrobium mukohataei JP60
hall  Halomicrobium sp. LC1Hm
hazp  Halomicrobium sp. ZPS1
hali  Halorientalis sp. IM1011
hsn  Halapricum salinum
hds  Halapricum desulfuricans
hrr  Halosimplex rubrum
hpel  Halosimplex pelagicum
hlt  Halosimplex litoreum
ssai  Salinirubellus salinus
haad  Halocatena salina
nph  Natronomonas pharaonis
nmo  Natronomonas moolapensis
nho  Natronomonas halophila
nsal  Natronomonas salina
hvo  Haloferax volcanii DS2
hale  Haloferax volcanii wsp1
hln  Haloferax volcanii SVX82
hme  Haloferax mediterranei
hgi  Haloferax gibbonsii
hls  Haloferax larsenii
hbo  Halogeometricum borinquense
haq  Haloplanus rubicundus CBA1112
haj  Haloplanus rubicundus CBA1113
haer  Haloplanus aerogenes
hra  Haloplanus rallus
hlm  Halobellus limi
halm  Haloprofundus sp. MHR1
hla  Halorubrum lacusprofundi
hezz  Halorubrum ezzemoulense
halq  Halorubrum sp. CBA1229
hsai  Halorubrum salinarum
hazz  Halorubrum sp. 2020YC2
halg  Halorarum halophilum
halu  Halorarum salinum
hmp  Halobaculum magnesiiphilum
hre  Halobaculum roseum
hrm  Halobaculum rubrum
hacb  Halobaculum sp. CBA1158
hdf  Halalkaliarchaeum desulfuricum
htu  Haloterrigena turkmenica
hsal  Haloterrigena salifodinae
hakz  Haloterrigena alkaliphila
nmg  Natrialba magadii
hxa  Halopiger xanaduensis
nat  Natrinema sp. J7-2
npe  Natrinema pellirubrum
nvr  Natrinema versiforme
npl  Natrinema pallidum
nay  Natrinema zhouii
haly  Natrinema halophilum
hjt  Natrinema thermotolerans
hlo  Natrinema longum
nge  Natronobacterium gregoryi
hlc  Natronobacterium lacisalsi
hru  Halovivax ruber
sawl  Natronosalvus rutilus
halv  Natronosalvus halobius
nou  Natronococcus occultus
hlr  Halostagnicola larsenii
naj  Natrarchaeobaculum aegyptiacum
nag  Natrarchaeobaculum sulfurireducens AArc-Mg
nan  Natrarchaeobaculum sulfurireducens AArc1
nara  Natrialbaceae archaeon AArc-T1-2
nbg  Natronorubrum bangense
nas  Natronorubrum aibiense
hda  Natronorubrum daqingense
pai  Pyrobaculum aerophilum
pis  Pyrobaculum islandicum
pcl  Pyrobaculum calidifontis
pas  Pyrobaculum arsenaticum
pyr  Pyrobaculum ferrireducens
pog  Pyrobaculum oguniense
tne  Pyrobaculum neutrophilum
pyw  Pyrobaculum sp. WP30
cma  Caldivirga maquilingensis
ttn  Thermoproteus tenax
tuz  Thermoproteus uzoniensis
vdi  Vulcanisaeta distributa
lob  Lokiarchaeum ossiferum
psyt  Promethearchaeum syntrophicum
 » show all
Reaction
R01226  
R02472  
R09378  
R09379  
R04231  
R03269  
R03035  
R12608  
Compound
C00141  3-Methyl-2-oxobutanoic acid
C00966  2-Dehydropantoate
C00522  (R)-Pantoate
C18911  (R)-4-Phosphopantoate
C03492  D-4'-Phosphopantothenate
C04352  (R)-4'-Phosphopantothenoyl-L-cysteine
C01134  Pantetheine 4'-phosphate
C00882  Dephospho-CoA
C00010  CoA
Reference
PMID:31337720
  Authors
Shimosaka T, Makarova KS, Koonin EV, Atomi H
  Title
Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea.
  Journal
mBio 10:e01146-19 (2019)
DOI:10.1128/mBio.01146-19
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