KEGG   MODULE: M01063
Entry
M01063            Pathway   Module                                 
Name
Ergothioneine anaerobic biosynthesis, histidine => ergothioneine
Definition
K18911 K28982
Diagram
M01063  Ergothioneine anaerobic biosynthesis, histidine => ergothioneine
M01063

Class
Pathway modules; Amino acid metabolism; Histidine metabolism
Pathway
map00340  Histidine metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K18911  
eanA; L-histidine Nalpha-methyltransferase [EC:2.1.1.44] [RN:R01169]
K28982  
eanB; hercynine sulfurtransferase [EC:2.8.1.-] [RN:R13641]
Complete
alus  Anaerohalosphaera lusitana
blq  Salinivirga cyanobacteriivorans
sahn  Salinimicrobium tongyeongense
sazs  Salinimicrobium sp. 3283s
cpb  Chlorobium phaeobacteroides BS1
cli  Chlorobium limicola
pros  Prosthecochloris sp. GSB1
prow  Prosthecochloris sp. SCSIO W1101
proi  Prosthecochloris sp. SCSIO W1103
sru  Salinibacter ruber DSM 13855
srm  Salinibacter ruber M8
mmh  Methanohalophilus mahii
mhaz  Methanohalophilus halophilus
mzh  Methanosalsum zhilinae
mpy  Methanolobus psychrophilus
mzi  Methanolobus zinderi
mseb  Methanolobus sediminis
 » show all
Reaction
Compound
C00135  L-Histidine
C05575  Hercynine
C05570  Ergothioneine
Reference
  Authors
Burn R, Misson L, Meury M, Seebeck FP.
  Title
Anaerobic Origin of Ergothioneine.
  Journal
Angew Chem Int Ed Engl 56:12508-12511 (2017)
DOI:10.1002/anie.201705932
Reference
  Authors
Liang L, Shan-Shan X, Yan-Jun J
  Title
Ergothioneine biosynthesis: The present state and future prospect.
  Journal
Synth Syst Biotechnol 10:314-325 (2025)
DOI:10.1016/j.synbio.2024.10.008
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