KEGG   NETWORK: N00063
Entry
N00063                      Network                                
Name
TGF-beta signaling pathway
Definition
TGFB -> (TGFBR2+TGFBR1) -> (SMAD2,SMAD3) == SMAD4
  Expanded
(7040,7042,7043) -> (7048+7046) -> (4087,4088) == 4089
Class
nt06507 TGFB signaling
nt06260 Colorectal cancer
nt06261 Gastric cancer
nt06263 Hepatocellular carcinoma
nt06276 Chronic myeloid leukemia
nt06218 TGFB signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06162 Hepatitis B virus (HBV)
Type
Reference
Pathway
hsa04350  TGF-beta signaling pathway
Gene
7040  TGFB1; transforming growth factor beta 1
7042  TGFB2; transforming growth factor beta 2
7043  TGFB3; transforming growth factor beta 3
7048  TGFBR2; transforming growth factor beta receptor 2
7046  TGFBR1; transforming growth factor beta receptor 1
4087  SMAD2; SMAD family member 2
4088  SMAD3; SMAD family member 3
4089  SMAD4; SMAD family member 4
Reference
PMID:18000526
  Authors
Schmierer B, Hill CS
  Title
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.
  Journal
Nat Rev Mol Cell Biol 8:970-82 (2007)
DOI:10.1038/nrm2297
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)
DOI:10.1146/annurev.biochem.67.1.753
Reference
PMID:20538542
  Authors
Yang L, Pang Y, Moses HL
  Title
TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression.
  Journal
Trends Immunol 31:220-7 (2010)
DOI:10.1016/j.it.2010.04.002
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