| Entry |
|
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| Name |
Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
|
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| Definition |
CDKN2A* // (CCND+CDK4/6) -> RB1 // E2F |
|---|
| Expanded |
1029v2 // ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871) |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
| H00004 | Chronic myeloid leukemia |
| H00014 | Non-small cell lung cancer |
|
|---|
| Gene |
| 1029 | CDKN2A; cyclin dependent kinase inhibitor 2A |
| 1019 | CDK4; cyclin dependent kinase 4 |
| 1021 | CDK6; cyclin dependent kinase 6 |
| 5925 | RB1; RB transcriptional corepressor 1 |
| 1869 | E2F1; E2F transcription factor 1 |
| 1870 | E2F2; E2F transcription factor 2 |
| 1871 | E2F3; E2F transcription factor 3 |
|
|---|
| Variant |
1029v2 (CDKN2A*) CDKN2A mutation
|
|---|
| Reference |
|
|---|
| Authors |
Schmid RM. |
|---|
| Title |
Genetic basis of pancreatic cancer. |
|---|
| Journal |
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|---|
| Reference |
|
|---|
| Authors |
Calabretta B, Perrotti D. |
|---|
| Title |
The biology of CML blast crisis. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Miller AJ, Mihm MC Jr. |
|---|
| Title |
Melanoma. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Meuwissen R, Berns A. |
|---|
| Title |
Mouse models for human lung cancer. |
|---|
| Journal |
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| LinkDB |
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