| Entry |
|
|---|
| Name |
Amplified CDK4 to cell cycle G1/S
|
|---|
| Definition |
(CCND+CDK4*) -> RB1 // E2F |
|---|
| Expanded |
((595,894,896)+1019v1) -> 5925 // (1869,1870,1871) |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
|
|---|
| Gene |
| 1019 | CDK4; cyclin dependent kinase 4 |
| 5925 | RB1; RB transcriptional corepressor 1 |
| 1869 | E2F1; E2F transcription factor 1 |
| 1870 | E2F2; E2F transcription factor 2 |
| 1871 | E2F3; E2F transcription factor 3 |
|
|---|
| Variant |
1019v1 (CDK4*) CDK4 amplification
|
|---|
| Reference |
|
|---|
| Authors |
Holland EC. |
|---|
| Title |
Gliomagenesis: genetic alterations and mouse models. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Soni D, King JA, Kaye AH, Hovens CM. |
|---|
| Title |
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Bansal K, Liang ML, Rutka JT. |
|---|
| Title |
Molecular biology of human gliomas. |
|---|
| Journal |
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|---|
| LinkDB |
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