| Entry |
|
|---|
| Name |
EML4-ALK fusion kinase to Jak-STAT signaling pathway
|
|---|
| Definition |
EML4-ALK -> JAK3 -> STAT3,STAT5 |
|---|
| Expanded |
(238v1,238v2) -> 3718 -> (6774,6776,6777) |
|---|
| Class |
nt06266 Non-small cell lung cancer
nt06219 JAK-STAT signaling (cancer)
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
| H00014 | Non-small cell lung cancer |
|
|---|
| Gene |
| 238 | ALK; ALK receptor tyrosine kinase |
| 3718 | JAK3; Janus kinase 3 |
| 6774 | STAT3; signal transducer and activator of transcription 3 |
| 6776 | STAT5A; signal transducer and activator of transcription 5A |
| 6777 | STAT5B; signal transducer and activator of transcription 5B |
|
|---|
| Variant |
238v1 (EML4-ALK) EML4-ALK fusion
238v2 (EML4-ALK) First generation TKI-resistant ALK1 mutation
|
|---|
| Reference |
|
|---|
| Authors |
Roskoski R Jr |
|---|
| Title |
Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Solomon B, Wilner KD, Shaw AT |
|---|
| Title |
Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
