Entry |
|
Name |
AML1-EVI1 fusion to TGF-beta signaling pathway
|
Definition |
AML1-EVI1 -| SMAD3 == SMAD4 |
Expanded |
861v1 -| 4088 == 4089 |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
H00004 | Chronic myeloid leukemia |
|
Gene |
861 | RUNX1; runt related transcription factor 1 |
4088 | SMAD3; SMAD family member 3 |
4089 | SMAD4; SMAD family member 4 |
|
Variant |
861v1 (AML1-EVI1) AML1-EVI1 fusion
|
Reference |
|
Authors |
Mitani K. |
Title |
Molecular mechanisms of leukemogenesis by AML1/EVI-1. |
Journal |
|
Reference |
|
Authors |
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H. |
Title |
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells. |
Journal |
Blood 92:4003-12 (1998) |
Reference |
|
Authors |
Dong M, Blobe GC. |
Title |
Role of transforming growth factor-beta in hematologic malignancies. |
Journal |
|
LinkDB |
|