 | | NETWORK: N00109 | |
| Entry |
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| Name |
PML-RARA fusion to transcriptional activtion
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| Definition |
PML-RARA => (JUP,CCNA1) |
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| Expanded |
5371v1 => (3728,8900) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 5371 | PML; promyelocytic leukemia |
| 3728 | JUP; junction plakoglobin |
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| Variant |
5371v1 (PML-RARA) PML-RARA fusion
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| Reference |
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| Authors |
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H |
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| Title |
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. |
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| Journal |
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| Reference |
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| Authors |
Muller C, Yang R, Park DJ, Serve H, Berdel WE, Koeffler HP |
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| Title |
The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. |
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| Journal |
Blood 96:3894-9 (2000) |
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| Reference |
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| Authors |
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG |
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| Title |
Common themes in the pathogenesis of acute myeloid leukemia. |
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| Journal |
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| LinkDB |
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