 | | NETWORK: N00110 | |
| Entry |
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| Name |
PLZF-RARA fusion to transcriptional activtion
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| Definition |
PLZF-RARA => (JUP,CCNA1,MYC) |
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| Expanded |
7704v1 => (3728,8900,4609) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 7704 | ZBTB16; zinc finger and BTB domain containing 16 |
| 3728 | JUP; junction plakoglobin |
| 4609 | MYC; MYC proto-oncogene, bHLH transcription factor |
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| Variant |
7704v1 (PLZF-RARA) PLZF-RARA fusion
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| Reference |
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| Authors |
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H |
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| Title |
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. |
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| Journal |
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| Reference |
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| Authors |
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG |
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| Title |
Common themes in the pathogenesis of acute myeloid leukemia. |
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| Journal |
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| Reference |
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| Authors |
Muller C, Yang R, Park DJ, Serve H, Berdel WE, Koeffler HP |
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| Title |
The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. |
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| Journal |
Blood 96:3894-9 (2000) |
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| Reference |
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| Authors |
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD |
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| Title |
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. |
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| Journal |
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| LinkDB |
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