KEGG   NETWORK: N00114
Entry
N00114                      Network                                
Name
PLZF-RARA fusion to transcriptional repression
Definition
PLZF-RARA =| DUSP6
  Expanded
7704v1 =| 1848
Class
nt06275 Acute myeloid leukemia
nt06240 Transcription (cancer)
Type
Variant
Pathway
hsa05221  Acute myeloid leukemia
Disease
H00003  Acute myeloid leukemia
Gene
7704  ZBTB16; zinc finger and BTB domain containing 16
1848  DUSP6; dual specificity phosphatase 6
Variant
7704v1 (PLZF-RARA)  PLZF-RARA fusion
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
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