 | | NETWORK: N00120 | |
| Entry |
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| Name |
MLL-ENL fusion to transcriptional activation
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| Definition |
MLL-ENL => (MEIS1,HOXA9,HOXA10,HOXA11,SIX1,SIX4,EYA1,CDKN2C,HPGD,GRIA3,FUT8) |
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| Expanded |
(4297v2,4298v1) => (4211,3205,3206,3207,6495,51804,2138,1031,3248,2892,2530) |
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| Class |
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| Type |
Variant
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| Disease |
| H00002 | T-cell acute lymphoblastic leukemia |
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| Gene |
| 4297 | KMT2A; lysine methyltransferase 2A |
| 4298 | MLLT1; MLLT1, super elongation complex subunit |
| 4211 | MEIS1; Meis homeobox 1 |
| 3206 | HOXA10; homeobox A10 |
| 3207 | HOXA11; homeobox A11 |
| 6495 | SIX1; SIX homeobox 1 |
| 51804 | SIX4; SIX homeobox 4 |
| 2138 | EYA1; EYA transcriptional coactivator and phosphatase 1 |
| 1031 | CDKN2C; cyclin dependent kinase inhibitor 2C |
| 3248 | HPGD; hydroxyprostaglandin dehydrogenase 15-(NAD) |
| 2892 | GRIA3; glutamate ionotropic receptor AMPA type subunit 3 |
| 2530 | FUT8; fucosyltransferase 8 |
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| Variant |
4297v2 (MLL-ENL) MLL-ENL fusion
4298v1 (MLL-ENL) MLL-ENL fusion
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| Reference |
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| Authors |
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ |
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| Title |
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. |
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| Journal |
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| Reference |
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| Authors |
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK |
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| Title |
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. |
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| Journal |
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| Reference |
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| Authors |
Horstmann M, Argyriou-Tirita A, Borkhardt A, Kabisch H, Kapaun P, Winkler K, Haas OA |
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| Title |
MLL/ENL fusion in congenital acute lymphoblastic leukemia with a unique t(11;18;19). |
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| Journal |
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| LinkDB |
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