NETWORK: N00135
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Entry
N00135 Network
Name
EWSR1-ERG fusion to transcriptional activation
Definition
EWSR1-ERG => IGF1
Expanded
2078v2 => 3479
Class
nt06240
Transcription
Type
Variant
Disease
H00035
Ewing sarcoma
Gene
2078
ERG; ERG, ETS transcription factor
3479
IGF1; insulin like growth factor 1
Variant
2078v2
(EWSR1-ERG) EWSR1-ERG fusion
Reference
PMID:
18648544
Authors
Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I
Title
IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
Journal
PLoS One 3:e2634 (2008)
DOI:
10.1371/journal.pone.0002634
Reference
PMID:
15826838
Authors
Aman P
Title
Fusion oncogenes in tumor development.
Journal
Semin Cancer Biol 15:236-43 (2005)
DOI:
10.1016/j.semcancer.2005.01.009
Reference
PMID:
12951587
Authors
Helman LJ, Meltzer P.
Title
Mechanisms of sarcoma development.
Journal
Nat Rev Cancer 3:685-94 (2003)
DOI:
10.1038/nrc1168
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