Entry Name IAV PB1-F2/PB2 to RIG-I-like receptor signaling pathway
Definition (PB1F2,PB2) -| MAVS
Expanded (K19397,K19388) -| 57506
Class Type Pathogen
Pathway Disease Gene 57506 MAVS; mitochondrial antiviral signaling protein
Perturbant K19397 (PB1F2) PB1F2; Influenza A virus protein PB1-F2
K19388 (PB2) PB2; Influenza A virus polymerase basic protein 2
Reference Authors van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Title Evasion of influenza A viruses from innate and adaptive immune responses.
Journal Reference Authors Varga ZT, Ramos I, Hai R, Schmolke M, Garcia-Sastre A, Fernandez-Sesma A, Palese P
Title The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.
Journal Reference Authors Dudek SE, Wixler L, Nordhoff C, Nordmann A, Anhlan D, Wixler V, Ludwig S
Title The influenza virus PB1-F2 protein has interferon antagonistic activity.
Journal Reference Authors Graef KM, Vreede FT, Lau YF, McCall AW, Carr SM, Subbarao K, Fodor E
Title The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.
Journal LinkDB All DBs
