KEGG   NETWORK: N00803
Entry
N00803                      Network                                
Name
Iodide organification/coupling reactions
Definition
TG+(Iodide+Tyr) -- TPO -> TG+(MIT,DIT) -- TPO -> TG+(T3,T4)
  Expanded
7038+(C00708+C00082) -- 7173 -> 7038+(C02515,C01060) -- 7173 -> 7038+(C02465,C01829)
Class
nt06322 TRH-TSH-TH signaling
Type
Reference
Pathway
hsa04918  Thyroid hormone synthesis
hsa00350  Tyrosine metabolism
Gene
7038  TG; thyroglobulin
7173  TPO; thyroid peroxidase
Metabolite
C00708  Iodide
C00082  L-Tyrosine
C02515  3-Iodo-L-tyrosine
C01060  3,5-Diiodo-L-tyrosine
C02465  Triiodothyronine
C01829  Thyroxine
Reference
PMID:30780803
  Authors
Leung A, Pearce EN, Braverman LE
  Title
Role of iodine in thyroid physiology.
  Journal
Expert Rev Endocrinol Metab 5:593-602 (2010)
DOI:10.1586/eem.10.40
Reference
PMID:25009573
  Authors
Pesce L, Kopp P
  Title
Iodide transport: implications for health and disease.
  Journal
Int J Pediatr Endocrinol 2014:8 (2014)
DOI:10.1186/1687-9856-2014-8
Reference
PMID:23890557
  Authors
Clinckspoor I, Verlinden L, Mathieu C, Bouillon R, Verstuyf A, Decallonne B
  Title
Vitamin D in thyroid tumorigenesis and development.
  Journal
Prog Histochem Cytochem 48:65-98 (2013)
DOI:10.1016/j.proghi.2013.07.001
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