KEGG   NETWORK: N00882
Entry
N00882                      Network                                
Name
TAC3-TACR3-PLC-PKC signaling pathway
Definition
TAC3 -> TACR3 -> GNAQ -> PLCB -> (Ca2+,DAG) -> PKC
  Expanded
6866 -> 6870 -> 2776 -> (23236,5330,5331,5332) -> (C00076,C00165) -> (5578,5579,5582)
Class
nt06323 KISS1-GnRH-LH/FSH-E2 signaling
nt06361 Hypogonadotropic hypogonadism
Type
Reference
Gene
6866  TAC3; tachykinin precursor 3
6870  TACR3; tachykinin receptor 3
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
Metabolite
C00076  Calcium cation
C00165  Diacylglycerol
Reference
PMID:8925404
  Authors
Khawaja AM, Rogers DF
  Title
Tachykinins: receptor to effector.
  Journal
Int J Biochem Cell Biol 28:721-38 (1996)
DOI:10.1016/1357-2725(96)00017-9
Reference
PMID:24376026
  Authors
Noel SD, Abreu AP, Xu S, Muyide T, Gianetti E, Tusset C, Carroll J, Latronico AC, Seminara SB, Carroll RS, Kaiser UB
  Title
TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients.
  Journal
FASEB J 28:1924-37 (2014)
DOI:10.1096/fj.13-240630
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