| Entry |
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| Name |
C9orf72-mediated autophagy initiation
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| Definition |
RAB1A -> (C9orf72+WDR41+SMCR8) -> ULK1_complex |
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| Expanded |
5861 -> (203228+55255+140775) -> (8408+9821+60673+9776) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 5861 | RAB1A; RAB1A, member RAS oncogene family |
| 203228 | C9orf72; C9orf72-SMCR8 complex subunit |
| 55255 | WDR41; WD repeat domain 41 |
| 140775 | SMCR8; SMCR8-C9orf72 complex subunit |
| 8408 | ULK1; unc-51 like autophagy activating kinase 1 |
| 9821 | RB1CC1; RB1 inducible coiled-coil 1 |
| 60673 | ATG101; autophagy related 101 |
| 9776 | ATG13; autophagy related 13 |
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| Reference |
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| Authors |
Webster CP, Smith EF, Grierson AJ, De Vos KJ |
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| Title |
C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy. |
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| Journal |
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| Reference |
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| Authors |
Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ |
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| Title |
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. |
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| Journal |
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| Reference |
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| Authors |
Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF |
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| Title |
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. |
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| Journal |
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| LinkDB |
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