KEGG   NETWORK: N01309
Entry
N01309                      Network                                

Name
SARS-CoV-2 nsp3 to MDA5-IRF7/3 signaling pathway
Definition
nsp3 -| ISG15 -- MDA5
  Expanded
K25013 -| 9636 -- 64135
Class
nt06133 RLR signaling (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Pathogen
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
9636  ISG15; ISG15 ubiquitin like modifier
64135  IFIH1; interferon induced with helicase C domain 1
Perturbant
K25013 (nsp3)  nsp3; SARS coronavirus non-structural protein 3
Reference
  Authors
Liu G, Lee JH, Parker ZM, Acharya D, Chiang JJ, van Gent M, Riedl W, Davis-Gardner ME, Wies E, Chiang C, Gack MU
  Title
ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease.
  Journal
bioRxiv 2020.10.26.356048 (2020)
DOI:10.1101/2020.10.26.356048
Reference
  Authors
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, van der Heden van Noort GJ, Geurink PP, Ovaa H, Newman J, Riboldi-Tunnicliffe A, Czabotar PE, Mitchell JP, Feltham R, Lechtenberg BC, Lowes KN, Dewson G, Pellegrini M, Lessene G, Komander D
  Title
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
  Journal
EMBO J e106275 (2020)
DOI:10.15252/embj.2020106275
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