KEGG   NETWORK: N01342
Entry
N01342                      Network                                
Name
Nicotine to Jak-STAT signaling pathway
Definition
Nicotine -> (CHRNA4+CHRNB2) -> JAK2 -> STAT3 => CCND1
  Expanded
C00745 -> (1137+1141) -> 3717 -> 6774 => 595
Class
nt06219 JAK-STAT signaling (cancer)
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00022  Bladder cancer
Gene
1137  CHRNA4; cholinergic receptor nicotinic alpha 4 subunit
1141  CHRNB2; cholinergic receptor nicotinic beta 2 subunit
3717  JAK2; Janus kinase 2
6774  STAT3; signal transducer and activator of transcription 3
595  CCND1; cyclin D1
Perturbant
C00745 (Nicotine)  Nicotine
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:20106947
  Authors
Chen RJ, Ho YS, Guo HR, Wang YJ
  Title
Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
  Journal
Toxicol Sci 115:118-30 (2010)
DOI:10.1093/toxsci/kfq028
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