KEGG   NETWORK: N01375
Entry
N01375                      Network                                

Name
DMBA to DNA adducts
Definition
DMBA -- CYP1A1 >> EPHX1 >> CYP1A1 -> DMBADE -- DNA
  Expanded
C19488 -- 1543 >> 2052 >> 1543 -> C19559 -- C00039
Class
nt06250 DNA adduct formation
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00031  Breast cancer
Gene
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1
2052  EPHX1; epoxide hydrolase 1
Perturbant
C19488 (DMBA)  7,12-Dimethylbenz[a]anthracene
Metabolite
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C00039  DNA
Reference
  Authors
Androutsopoulos VP, Tsatsakis AM, Spandidos DA
  Title
Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.
  Journal
BMC Cancer 9:187 (2009)
DOI:10.1186/1471-2407-9-187
Reference
  Authors
Gonzalez FJ, Kimura S
  Title
Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice.
  Journal
Mutat Res 477:79-87 (2001)
DOI:10.1016/S0027-5107(01)00109-9
Reference
  Authors
Melendez-Colon VJ, Luch A, Seidel A, Baird WM
  Title
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.
  Journal
Carcinogenesis 20:1885-91 (1999)
DOI:10.1093/carcin/20.10.1885
Reference
PMID:9288883
  Authors
Arif JM, Smith WA, Gupta RC
  Title
Tissue distribution of DNA adducts in rats treated by intramammillary injection with dibenzo[a,l]pyrene, 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene.
  Journal
Mutat Res 378:31-9 (1997)
DOI:10.1016/s0027-5107(97)00095-x
Reference
  Authors
Ledet MM, Oswald M, Anderson R, Van de Walle GR
  Title
Differential signaling pathway activation in 7,12-dimethylbenz[a] anthracene (DMBA)-treated mammary stem/progenitor cells from species with varying mammary cancer incidence.
  Journal
Oncotarget 9:32761-32774 (2018)
DOI:10.18632/oncotarget.25988
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