KEGG   NETWORK: N01376
Entry
N01376                      Network                                
Name
Melphalan to DNA adducts/cross-links
Definition
Melphalan == DNA
  Expanded
C07122 == C00039
Class
nt06250 DNA adduct formation (cancer)
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00003  Acute myeloid leukemia
Perturbant
C07122 (Melphalan)  Melphalan
Metabolite
C00039  DNA
Reference
PMID:11092599
  Authors
Hoes I, Van Dongen W, Lemiere F, Esmans EL, Van Bockstaele D, Berneman ZN
  Title
Comparison between capillary and nano liquid chromatography-electrospray mass spectrometry for the analysis of minor DNA-melphalan adducts.
  Journal
J Chromatogr B Biomed Sci Appl 748:197-212 (2000)
DOI:10.1016/S0378-4347(00)00400-X
Reference
PMID:15135647
  Authors
Cordelli E, Cinelli S, Lascialfari A, Ranaldi R, Pacchierotti F
  Title
Melphalan-induced DNA damage in p53(+/-) and wild type mice analysed by the comet assay.
  Journal
Mutat Res 550:133-43 (2004)
DOI:10.1016/j.mrfmmm.2004.02.012
Reference
PMID:15257621
  Authors
Balcome S, Park S, Quirk Dorr DR, Hafner L, Phillips L, Tretyakova N
  Title
Adenine-containing DNA-DNA cross-links of antitumor nitrogen mustards.
  Journal
Chem Res Toxicol 17:950-62 (2004)
DOI:10.1021/tx0499463
Reference
PMID:7527485
  Authors
Povirk LF, Shuker DE
  Title
DNA damage and mutagenesis induced by nitrogen mustards.
  Journal
Mutat Res 318:205-26 (1994)
DOI:10.1016/0165-1110(94)90015-9
Reference
PMID:11378539
  Authors
Leone G, Voso MT, Sica S, Morosetti R, Pagano L
  Title
Therapy related leukemias: susceptibility, prevention and treatment.
  Journal
Leuk Lymphoma 41:255-76 (2001)
DOI:10.3109/10428190109057981
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