KEGG   NETWORK: N01377
Entry
N01377                      Network                                
Name
Thiotepa to DNA adducts/cross-links
Definition
Thiotepa == DNA
  Expanded
C07641 == C00039
Class
nt06250 DNA adduct formation (cancer)
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00003  Acute myeloid leukemia
Perturbant
C07641 (Thiotepa)  Thiotepa
Metabolite
C00039  DNA
Reference
  Authors
Maanen MJ, Smeets CJ, Beijnen JH
  Title
Chemistry, pharmacology and pharmacokinetics of N,N',N" -triethylenethiophosphoramide (ThioTEPA).
  Journal
Cancer Treat Rev 26:257-68 (2000)
DOI:10.1053/ctrv.2000.0170
Reference
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
  Authors
Birkett N, Al-Zoughool M, Bird M, Baan RA, Zielinski J, Krewski D
  Title
Overview of biological mechanisms of human carcinogens.
  Journal
J Toxicol Environ Health B Crit Rev 22:288-359 (2019)
DOI:10.1080/10937404.2019.1643539
Reference
  Authors
Shah N, Rauenzahn S, Veltri L, Wen S, Craig M, Hamadani M, Kanate AS, Cumpston A
  Title
Long-term outcomes after thiotepa-based high-dose therapy (HDT) and autologous hematopoietic cell transplantation (auto-HCT) in non-Hodgkin lymphoma (NHL).
  Journal
Bone Marrow Transplant 52:321-322 (2017)
DOI:10.1038/bmt.2016.275
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