KEGG   NETWORK: N01475
Entry
N01475                      Network                                
Name
Telomerase RNA maturation
Definition
TERC+TGS1 -> TERC+PAPD5 -> TERC+PARN+ZCCHC8
  Expanded
7012+96764 -> 7012+64282 -> 7012+5073+55596
Class
nt06510 Telomere length regulation
Type
Reference
Gene
7012  TERC; telomerase RNA component
96764  TGS1; trimethylguanosine synthase 1
64282  TENT4B; terminal nucleotidyltransferase 4B
5073  PARN; poly(A)-specific ribonuclease
55596  ZCCHC8; zinc finger CCHC-type containing 8
Reference
PMID:33482595
  Authors
Grill S, Nandakumar J
  Title
Molecular mechanisms of telomere biology disorders.
  Journal
J Biol Chem 296:100064 (2021)
DOI:10.1074/jbc.REV120.014017
Reference
PMID:32242127
  Authors
Roake CM, Artandi SE
  Title
Regulation of human telomerase in homeostasis and disease.
  Journal
Nat Rev Mol Cell Biol 21:384-397 (2020)
DOI:10.1038/s41580-020-0234-z
Reference
PMID:31488579
  Authors
Gable DL, Gaysinskaya V, Atik CC, Talbot CC Jr, Kang B, Stanley SE, Pugh EW, Amat-Codina N, Schenk KM, Arcasoy MO, Brayton C, Florea L, Armanios M
  Title
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.
  Journal
Genes Dev 33:1381-1396 (2019)
DOI:10.1101/gad.326785.119
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