KEGG   NETWORK: N01476
Entry
N01476                      Network                                
Name
Assembly and trafficking of telomerase
Definition
TERC+TERT+Pontin+Reptin == DKC1+NOP10+NHP2+GAR1+NAF1 -> TERC+TERT+Pontin+Reptin+Dyskerins == WRAP53+TriC
  Expanded
7012+7015+8607+10856 == 1736+55505+55651+54433+92345 -> 7012+7015+8607+10856+1736+55505+55651+54433 == 55135+6950+10576+7203+10575+22948+908+10693+10574+10694
Class
nt06510 Telomere length regulation
Type
Reference
Gene
7012  TERC; telomerase RNA component
7015  TERT; telomerase reverse transcriptase
8607  RUVBL1; RuvB like AAA ATPase 1
10856  RUVBL2; RuvB like AAA ATPase 2
1736  DKC1; dyskerin pseudouridine synthase 1
55505  NOP10; NOP10 ribonucleoprotein
55651  NHP2; NHP2 ribonucleoprotein
54433  GAR1; GAR1 ribonucleoprotein
92345  NAF1; nuclear assembly factor 1 ribonucleoprotein
55135  WRAP53; WD repeat containing antisense to TP53
6950  TCP1; t-complex 1
10576  CCT2; chaperonin containing TCP1 subunit 2
7203  CCT3; chaperonin containing TCP1 subunit 3
10575  CCT4; chaperonin containing TCP1 subunit 4
22948  CCT5; chaperonin containing TCP1 subunit 5
908  CCT6A; chaperonin containing TCP1 subunit 6A
10693  CCT6B; chaperonin containing TCP1 subunit 6B
10574  CCT7; chaperonin containing TCP1 subunit 7
10694  CCT8; chaperonin containing TCP1 subunit 8
Reference
PMID:33482595
  Authors
Grill S, Nandakumar J
  Title
Molecular mechanisms of telomere biology disorders.
  Journal
J Biol Chem 296:100064 (2021)
DOI:10.1074/jbc.REV120.014017
Reference
PMID:32242127
  Authors
Roake CM, Artandi SE
  Title
Regulation of human telomerase in homeostasis and disease.
  Journal
Nat Rev Mol Cell Biol 21:384-397 (2020)
DOI:10.1038/s41580-020-0234-z
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