KEGG   NETWORK: N01477
Entry
N01477                      Network                                
Name
Telomere elongation
Definition
RTEL1+RAP1+TRF2+TIN2+TRF1+POT1+ACD == telomerase -> Shelterin == CTC1+STN1+TEN1
  Expanded
51750+54386+7014+26277+7013+25913+65057 == 7015+7012+8607+10856+1736+55505+55651+54433+55135 -> 54386+7014+26277+7013+25913+65057 == 80169+79991+100134934
Class
nt06510 Telomere length regulation
Type
Reference
Gene
51750  RTEL1; regulator of telomere elongation helicase 1
54386  TERF2IP; TERF2 interacting protein
7014  TERF2; telomeric repeat binding factor 2
26277  TINF2; TERF1 interacting nuclear factor 2
7013  TERF1; telomeric repeat binding factor 1
25913  POT1; protection of telomeres 1
65057  ACD; ACD shelterin complex subunit and telomerase recruitment factor
7015  TERT; telomerase reverse transcriptase
7012  TERC; telomerase RNA component
8607  RUVBL1; RuvB like AAA ATPase 1
10856  RUVBL2; RuvB like AAA ATPase 2
1736  DKC1; dyskerin pseudouridine synthase 1
55505  NOP10; NOP10 ribonucleoprotein
55651  NHP2; NHP2 ribonucleoprotein
54433  GAR1; GAR1 ribonucleoprotein
55135  WRAP53; WD repeat containing antisense to TP53
80169  CTC1; CST telomere replication complex component 1
79991  STN1; STN1 subunit of CST complex
100134934  TEN1; TEN1 subunit of CST complex
Reference
PMID:33482595
  Authors
Grill S, Nandakumar J
  Title
Molecular mechanisms of telomere biology disorders.
  Journal
J Biol Chem 296:100064 (2021)
DOI:10.1074/jbc.REV120.014017
Reference
PMID:32242127
  Authors
Roake CM, Artandi SE
  Title
Regulation of human telomerase in homeostasis and disease.
  Journal
Nat Rev Mol Cell Biol 21:384-397 (2020)
DOI:10.1038/s41580-020-0234-z
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