KEGG   NETWORK: N01590
Entry
N01590                      Network                                
Name
Arachidonate/Adrenic acid metabolism
Definition
AA+CoA -- ACSL4 >> LPCAT3 >> ALOX15 -> PE-AA-O-OH
  Expanded
(C00219,C16527)+C00010 -- 2182 >> 10162 >> 246 -> C21483
Class
nt06525 Ferroptosis
Type
Reference
Pathway
hsa04216  Ferroptosis
Gene
2182  ACSL4; acyl-CoA synthetase long chain family member 4
10162  LPCAT3; lysophosphatidylcholine acyltransferase 3
246  ALOX15; arachidonate 15-lipoxygenase
Metabolite
C00219  Arachidonate
C16527  Adrenic acid
C00010  CoA
C21483  1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
Reference
PMID:27842070
  Authors
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trumbach D, Mao G, Qu F, Bayir H, Fullekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M
  Title
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
  Journal
Nat Chem Biol 13:91-98 (2017)
DOI:10.1038/nchembio.2239
Reference
PMID:32804006
  Authors
Chen X, Li J, Kang R, Klionsky DJ, Tang D
  Title
Ferroptosis: machinery and regulation.
  Journal
Autophagy 17:2054-2081 (2021)
DOI:10.1080/15548627.2020.1810918
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