| Entry |
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| Name |
Blood group H (O) antigen type 2 biosynthesis
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| Definition |
LacCer -- B3GNT5 >> B4GALT1/2/3/4 -> nLc4Cer -- FUT1*H -> TypeIIH // ABO*O |
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| Expanded |
G00092 -- 84002 >> (2683,8704,8703,8702) -> G00050 -- 2523v1 -> G00055 // 28v3 |
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| Class |
nt06035 Blood group carbohydrate antigen biosynthesis
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| Type |
Reference
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| Pathway |
| hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series |
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| Gene |
| 84002 | B3GNT5; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 |
| 2683 | B4GALT1; beta-1,4-galactosyltransferase 1 |
| 8704 | B4GALT2; beta-1,4-galactosyltransferase 2 |
| 8703 | B4GALT3; beta-1,4-galactosyltransferase 3 |
| 8702 | B4GALT4; beta-1,4-galactosyltransferase 4 |
| 2523 | FUT1; fucosyltransferase 1 (H blood group) |
| 28 | ABO; ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase |
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| Variant |
2523v1 (FUT1*H) FUT1 H allele
28v3 (ABO*O) ABO O allele
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| Metabolite |
| G00050 | Paragloboside (nLc4Cer) |
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| Reference |
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| Authors |
Jajosky RP, Wu SC, Zheng L, Jajosky AN, Jajosky PG, Josephson CD, Hollenhorst MA, Sackstein R, Cummings RD, Arthur CM, Stowell SR |
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| Title |
ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies. |
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| Journal |
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| Reference |
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| Authors |
Hosoi E |
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| Title |
Biological and clinical aspects of ABO blood group system. |
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| Journal |
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| LinkDB |
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