KEGG   NETWORK: N01676
Entry
N01676                      Network                                
Name
P1 antigen biosynthesis
Definition
nLc4Cer -- A4GALT*P1/NOR -> P1
  Expanded
G00050 -- (53947v1,53947v2) -> G00428
Class
nt06035 Blood group carbohydrate antigen biosynthesis
Type
Reference
Pathway
hsa00601  Glycosphingolipid biosynthesis - lacto and neolacto series
Gene
53947  A4GALT; alpha 1,4-galactosyltransferase (P blood group)
Variant
53947v1 (A4GALT*P1)  A4GALT P1+, Pk+ allele
53947v2 (A4GALT*NOR)  A4GALT P1+, Pk+, NOR+ allele
Metabolite
G00050  Paragloboside (nLc4Cer)
G00428  IV4Gala-nLc4-Cer
Reference
PMID:26773500
  Authors
Kaczmarek R, Duk M, Szymczak K, Korchagina E, Tyborowska J, Mikolajczyk K, Bovin N, Szewczyk B, Jaskiewicz E, Czerwinski M
  Title
Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR  blood group antigens.
  Journal
Biochem Biophys Res Commun 470:168-174 (2016)
DOI:10.1016/j.bbrc.2016.01.017
Reference
PMID:20971946
  Authors
Thuresson B, Westman JS, Olsson ML
  Title
Identification of a novel A4GALT exon reveals the genetic basis of the P1/P2 histo-blood groups.
  Journal
Blood 117:678-87 (2011)
DOI:10.1182/blood-2010-08-301333
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