KEGG   NETWORK: N01748
Entry
N01748                      Network                                
Name
Find-me signal (LPC)
Definition
CASP3 -> PLA2G6 -> LPC(inner) -- ABCA1 -> LPC(outer) -> GPR132
  Expanded
836 -> 8398 -> C04230 -- 19 -> C04230 -> 29933
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
836  CASP3; caspase 3
8398  PLA2G6; phospholipase A2 group VI
19  ABCA1; ATP binding cassette subfamily A member 1
29933  GPR132; G protein-coupled receptor 132
Metabolite
C04230  1-Acyl-sn-glycero-3-phosphocholine
Reference
  Authors
Li Y, Li Q, Fan GC
  Title
Macrophage Efferocytosis in Cardiac Pathophysiology and Repair.
  Journal
Shock 55:177-188 (2021)
DOI:10.1097/SHK.0000000000001625
Reference
  Authors
Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K
  Title
Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
  Journal
Autoimmunity 45:568-73 (2012)
DOI:10.3109/08916934.2012.719947
Reference
  Authors
Lauber K, Bohn E, Krober SM, Xiao YJ, Blumenthal SG, Lindemann RK, Marini P, Wiedig C, Zobywalski A, Baksh S, Xu Y, Autenrieth IB, Schulze-Osthoff K, Belka C, Stuhler G, Wesselborg S
  Title
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.
  Journal
Cell 113:717-30 (2003)
DOI:10.1016/s0092-8674(03)00422-7
Reference
  Authors
Medina CB, Ravichandran KS
  Title
Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes.
  Journal
Cell Death Differ 23:979-89 (2016)
DOI:10.1038/cdd.2016.13
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