KEGG   NETWORK: N01773
Entry
N01773                      Network                                
Name
PTGS2-PGE2-TGFB1 pathway
Definition
PTGS2 -> PGE2 -> EP2,EP4 -> CREB1+DNMT3A => TGFB1
  Expanded
5743 -> C00584 -> 5732,5734 -> 1385+1788 => 7040
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
5743  PTGS2; prostaglandin-endoperoxide synthase 2
5732  PTGER2; prostaglandin E receptor 2
5734  PTGER4; prostaglandin E receptor 4
1385  CREB1; cAMP responsive element binding protein 1
1788  DNMT3A; DNA methyltransferase 3 alpha
7040  TGFB1; transforming growth factor beta 1
Metabolite
C00584  Prostaglandin E2
Reference
PMID:35361955
  Authors
Ampomah PB, Cai B, Sukka SR, Gerlach BD, Yurdagul A Jr, Wang X, Kuriakose G, Darville LNF, Sun Y, Sidoli S, Koomen JM, Tall AR, Tabas I
  Title
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution.
  Journal
Nat Metab 4:444-457 (2022)
DOI:10.1038/s42255-022-00551-7
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