Entry Name Transfer of cobalamin to the portal blood
Definition R-Cbl(lysosome) -- LMBRD1+ABCD4 -> R-Cbl(cyto) -- ABCC1 -> R-Cbl(ECM)+TCN2 -- CD320
Expanded (C02823,C06453,C00194,C08230) -- 55788+5826 -> (C02823,C06453,C00194,C08230) -- 4363 -> (C02823,C06453,C00194,C08230)+6948 -- 51293
Class nt06538 Cobalamin transport and metabolism
Type Reference
Pathway hsa04980 Cobalamin transport and metabolism
Gene 55788 LMBRD1; LMBR1 domain containing 1
5826 ABCD4; ATP binding cassette subfamily D member 4
4363 ABCC1; ATP binding cassette subfamily C member 1 (ABCC1 blood group)
6948 TCN2; transcobalamin 2
51293 CD320; CD320 molecule
Metabolite Reference Authors Green R
Title Ins and outs of cellular cobalamin transport.
Journal Reference Authors Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
Title Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency Detected by Newborn Screening.
Journal Reference Authors Kawaguchi K, Okamoto T, Morita M, Imanaka T
Title Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1.
Journal Reference Authors Quadros EV, Regec AL, Khan KM, Quadros E, Rothenberg SP
Title Transcobalamin II synthesized in the intestinal villi facilitates transfer of cobalamin to the portal blood.
Journal LinkDB All DBs
