KEGG   NETWORK: N01871
Entry
N01871                      Network                                
Name
Hydroxylation of HIF
Definition
(HIF1A,EPAS1) -- EGLN -> (HIF1A-OH,EPAS1-OH)
  Expanded
(3091,2034) -- (54583,112398,112399) -> (3091,2034)
Class
nt06542 HIF signaling
Type
Reference
Gene
3091  HIF1A; hypoxia inducible factor 1 subunit alpha
2034  EPAS1; endothelial PAS domain protein 1
54583  EGLN1; egl-9 family hypoxia inducible factor 1
112398  EGLN2; egl-9 family hypoxia inducible factor 2
112399  EGLN3; egl-9 family hypoxia inducible factor 3
Reference
  Authors
Kaelin WG Jr, Ratcliffe PJ
  Title
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
  Journal
Mol Cell 30:393-402 (2008)
DOI:10.1016/j.molcel.2008.04.009
Reference
  Authors
Kristan A, Pajic T, Maver A, Rezen T, Kunej T, Kolic R, Vuga A, Fink M, Zula S, Podgornik H, Anzej Doma S, Preloznik Zupan I, Rozman D, Debeljak N
  Title
Identification of Variants Associated With Rare Hematological Disorder Erythrocytosis Using Targeted Next-Generation Sequencing Analysis.
  Journal
Front Genet 12:689868 (2021)
DOI:10.3389/fgene.2021.689868
Reference
  Authors
Strocchi S, Reggiani F, Gobbi G, Ciarrocchi A, Sancisi V
  Title
The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation.
  Journal
Oncogene 41:3665-3679 (2022)
DOI:10.1038/s41388-022-02378-8
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